Results 21 to 30 of about 45,133 (250)
Pharmaceuticals, 2023 Oxaliplatin (OXAL) is a commonly used chemotherapy for treating colorectal cancer (CRC). A recent genome wide association study (GWAS) showed that a genetic variant (rs11006706) in the lncRNA gene MKX-AS1 and partnered sense gene MKX could impact the ...
Ricardo D. Gonzalez +9 more
doaj +1 more source
Antisense-strand transcription correlates with sense-strand reactivation.
, 2023 (A) DESeq2-normalised counts for sense and antisense strand transcripts normalised to their maximum values. (B) DESeq2-normalised counts of reads aligned to the proviral sense or antisense-strand exons. Linear model fit with 95% confidence interval shown.
David S. Rueda (7879094) +3 more
core +1 more source
TNF-α plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease
Journal of Lipid Research, 2009 Niemann-Pick type C (NPC) is a fatal autosomal recessive lysosomal storage disease clinically characterized by neurodegeneration and liver disease.
Victoria M. Rimkunas +3 more
doaj +1 more source
Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient
Frontiers in Pain Research, 2022 Advances in our understanding of the biology of spinal systems in organizing and defining the content of exteroceptive information upon which higher centers define the state of the organism and its role in the regulation of somatic and automatic output ...
Jose De Andres +14 more
doaj +1 more source
CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity [PDF]
, 2012 In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.
Franch i Masferrer, Àngels +6 more
core +1 more source
Molecular Therapy: Nucleic Acids, 2015 Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting factor for development, and only few successful studies have been
Camilla Brolin +5 more
doaj +1 more source
The Medicinal Chemistry of Artificial Nucleic Acids and Therapeutic Oligonucleotides
Pharmaceuticals, 2022 Nucleic acids play a central role in human biology, making them suitable and attractive tools for therapeutic applications. While conventional drugs generally target proteins and induce transient therapeutic effects, nucleic acid medicines can achieve ...
Miklós Bege, Anikó Borbás
doaj +1 more source
New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins [PDF]
Diabetes & Metabolism Journal, 2022 Statins are the cornerstone of the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, even under optimal statin therapy, a significant residual ASCVD risk remains.
Kyuho Kim +2 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2001 The serine/threonine kinases, Akti/PKBα, Akt2/PKBβ, and Akt3/PKBγ, play a critical role in preventing cancer cells from undergoing apoptosis. However, the function of individual Akt isoforms in the tumorigenicity of cancer cells is still not well defined.
Xuesong Liu +7 more
doaj +1 more source
Antisense oligonucleotides [PDF]
Neurology Genetics, 2019 There are few disease-modifying therapeutics for neurodegenerative diseases, but successes on the development of antisense oligonucleotide (ASO) therapeutics for spinal muscular atrophy and Duchenne muscular dystrophy predict a robust future for ASOs in medicine.
Scoles, Daniel R. +2 more
openaire +2 more sources