Results 21 to 30 of about 378,124 (311)
Molecular Therapy: Nucleic Acids, 2018 Chemically modified antisense oligonucleotides with phosphorothioate linkages (PS-ASOs) mediate site-specific cleavage of RNA by RNase H1 and are broadly used as research and therapeutic tools.
Shiyu Wang +3 more
doaj +1 more source
Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA. [PDF]
, 1985 The bacteriophage SP6 promoter and RNA polymerase were used to synthesize sense and antisense RNAs coding for the enzymes thymidine kinase (TK) and chloramphenicol acetyl transferase (CAT).
HARLAND, Richard M., Weintraub, H
core +2 more sources
Journal for ImmunoTherapy of Cancer, 2018 Background The Janus kinase (JAK) and signal transduction and activation of transcription (STAT) signaling pathway is an attractive target in multiple cancers. Activation of the JAK-STAT pathway is important in both tumorigenesis and activation of immune
Matthew J. Reilley +26 more
doaj +1 more source
Pharmaceuticals, 2023 Oxaliplatin (OXAL) is a commonly used chemotherapy for treating colorectal cancer (CRC). A recent genome wide association study (GWAS) showed that a genetic variant (rs11006706) in the lncRNA gene MKX-AS1 and partnered sense gene MKX could impact the ...
Ricardo D. Gonzalez +9 more
doaj +1 more source
The Circadian Clock Gene Period1 Connects the Molecular Clock to Neural Activity in the Suprachiasmatic Nucleus. [PDF]
, 2015 The neural activity patterns of suprachiasmatic nucleus (SCN) neurons are dynamically regulated throughout the circadian cycle with highest levels of spontaneous action potentials during the day.
Block, Gene D +2 more
core +1 more source
Antisense oligonucleotides [PDF]
Neurology Genetics, 2019 There are few disease-modifying therapeutics for neurodegenerative diseases, but successes on the development of antisense oligonucleotide (ASO) therapeutics for spinal muscular atrophy and Duchenne muscular dystrophy predict a robust future for ASOs in medicine.
Scoles, Daniel R. +2 more
openaire +2 more sources
TNF-α plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease
Journal of Lipid Research, 2009 Niemann-Pick type C (NPC) is a fatal autosomal recessive lysosomal storage disease clinically characterized by neurodegeneration and liver disease.
Victoria M. Rimkunas +3 more
doaj +1 more source
Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient
Frontiers in Pain Research, 2022 Advances in our understanding of the biology of spinal systems in organizing and defining the content of exteroceptive information upon which higher centers define the state of the organism and its role in the regulation of somatic and automatic output ...
Jose De Andres +14 more
doaj +1 more source
Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]
, 2007 The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li +4 more
core +2 more sources
Differential expression of cellulose synthase (CesA) gene transcripts in potato as revealed by QRT-PCR [PDF]
, 2009 Two transgenic potato lines, csr2–1 and csr4–8 that contained two different antisense cellulose synthase (CesA) genes, csr2 and csr4, respectively were crossed.
Jacobsen, E. +3 more
core +2 more sources