Results 241 to 250 of about 443,792 (339)

A fully automated novel solid-phase extraction method for siRNA drug extraction and quantitation across multiple tissues using LC-MS. [PDF]

Bioanalysis
Karlsborn T, Stenbratt CL, Nain-Perez A, Hölttä M.   +3 more
europepmc   +1 more source

Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease.

New England Journal of Medicine, 2015
G. Monteleone, M. Neurath, S. Ardizzone, A. Di Sabatino, M. Fantini, F. Castiglione, M. Scribano, A. Armuzzi, F. Caprioli, G. Sturniolo, F. Rogai, M. Vecchi, R. Atreya, F. Bossa, S. Onali, M. Fichera, G. Corazza, L. Biancone, V. Savarino, R. Pica, A. Orlando, F. Pallone   +21 more
semanticscholar   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles. [PDF]

Neuropsychopharmacology
Chrisman AN, Sugimoto C, Butler-Struben H, Minie VA, Eagle AL, Anderson D, Duque-Wilckens N, Ramos A, Lewis YI, Archdeacon SC, Robison AJ, Trainor BC.   +11 more
europepmc   +1 more source

Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts

Science, 2016
N. Kramer, Y. Carlomagno, Yong-Jie Zhang, S. Almeida, C. Cook, Tania F. Gendron, M. Prudencio, M. van Blitterswijk, Veronique V. Belzil, Julien Couthouis, Joseph W Paul, Lindsey D. Goodman, Lillian M. Daughrity, Jeannie Chew, Aliesha D O'Raw, L. Pregent, Karen R. Jansen-West, Lilia J. Tabassian, R. Rademakers, K. Boylan, N. Graff-Radford, K. Josephs, J. Parisi, D. Knopman, R. Petersen, B. Boeve, Ning Deng, Yanan Feng, Tzu-Hao Cheng, D. Dickson, Stanley N Cohen, N. Bonini, C. Link, F. Gao, L. Petrucelli, A. Gitler   +35 more
semanticscholar   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Therapeutic Efficacy and Safety Profile of Eplontersen in Hereditary Transthyretin-Mediated Amyloidosis: A Systematic Review. [PDF]

Health Sci Rep
Patel ZV, Kumari V, Paras, Deepak BL, Prajjwal P, Deep KN, Bai R, John SS, Hussin OA.   +8 more
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Weaknesses out of strength: PNA against the penicillin-binding proteins. [PDF]

Mol Ther Nucleic Acids
Wdowiak M.
europepmc   +1 more source

Empirical antisense [PDF]

Nature Biotechnology, 1997
openaire   +1 more source