Results 31 to 40 of about 443,792 (339)
Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro [PDF]
, 2013 BACKGROUND: Mycobacterium bovis, the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during infection via a diverse range of mechanisms that subvert the host immune response.
Browne, JA +13 more
core +2 more sources
Peptide antisense nanoparticles [PDF]
Proceedings of the National Academy of Sciences, 2008 We have designed a heterofunctionalized nanoparticle conjugate consisting of a 13-nm gold nanoparticle (Au NP) containing both antisense oligonucleotides and synthetic peptides. The synthesis of this conjugate is accomplished by mixing thiolated oligonucleotides and cysteine-terminated peptides with gold nanoparticles in the presence of salt, which ...
Pinal C, Patel +3 more
openaire +2 more sources
TNF-α plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease
Journal of Lipid Research, 2009 Niemann-Pick type C (NPC) is a fatal autosomal recessive lysosomal storage disease clinically characterized by neurodegeneration and liver disease.
Victoria M. Rimkunas +3 more
doaj +1 more source
Intrathecal Drug Delivery: Advances and Applications in the Management of Chronic Pain Patient
Frontiers in Pain Research, 2022 Advances in our understanding of the biology of spinal systems in organizing and defining the content of exteroceptive information upon which higher centers define the state of the organism and its role in the regulation of somatic and automatic output ...
Jose De Andres +14 more
doaj +1 more source
Regulation of Antisense Transcription by NuA4 Histone Acetyltransferase and Other Chromatin Regulatory Factors. [PDF]
, 2016 NuA4 histone lysine (K) acetyltransferase (KAT) promotes transcriptional initiation of TATA-binding protein (TBP)-associated factor (TAF)-dependent ribosomal protein genes.
Bhaumik, Sukesh R +4 more
core +1 more source
Antisense Oligonucleotide Therapies for Neurodegenerative Diseases.
Annual Review of Neuroscience, 2019 Antisense oligonucleotides represent a novel therapeutic platform for the discovery of medicines that have the potential to treat most neurodegenerative diseases.
C. Bennett, A. Krainer, D. Cleveland
semanticscholar +1 more source
Lignin engineering in forest trees [PDF]
, 2019 Wood is a renewable resource that is mainly composed of lignin and cell wall polysaccharides. The polysaccharide fraction is valuable as it can be converted into pulp and paper, or into fermentable sugars.
Alvarenga Chanoca, Alexandra +2 more
core +1 more source
Natural antisense transcripts [PDF]
Human Molecular Genetics, 2014 Recent years have seen the increasing understanding of the crucial role of RNA in the functioning of the eukaryotic genome. These discoveries, fueled by the achievements of the FANTOM, and later GENCODE and ENCODE consortia, led to the recognition of the important regulatory roles of natural antisense transcripts (NATs) arising from what was previously
Olga, Khorkova +3 more
openaire +2 more sources
Molecular Therapy: Nucleic Acids, 2015 Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting factor for development, and only few successful studies have been
Camilla Brolin +5 more
doaj +1 more source
The Medicinal Chemistry of Artificial Nucleic Acids and Therapeutic Oligonucleotides
Pharmaceuticals, 2022 Nucleic acids play a central role in human biology, making them suitable and attractive tools for therapeutic applications. While conventional drugs generally target proteins and induce transient therapeutic effects, nucleic acid medicines can achieve ...
Miklós Bege, Anikó Borbás
doaj +1 more source