Results 41 to 50 of about 443,792 (339)
New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins [PDF]
Diabetes & Metabolism Journal, 2022 Statins are the cornerstone of the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, even under optimal statin therapy, a significant residual ASCVD risk remains.
Kyuho Kim +2 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2001 The serine/threonine kinases, Akti/PKBα, Akt2/PKBβ, and Akt3/PKBγ, play a critical role in preventing cancer cells from undergoing apoptosis. However, the function of individual Akt isoforms in the tumorigenicity of cancer cells is still not well defined.
Xuesong Liu +7 more
doaj +1 more source
Cfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells [PDF]
, 2014 BackgroundTrimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity dependent manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in ...
Bird, Adrian +2 more
core +1 more source
THERAPEUTIC ANTISENSE OLIGONUCLEOTIDES AGAINST CANCER: HURDLING TO THE CLINIC
Frontiers in Chemistry, 2014 Under clinical development since the early 90’s and with two successfully approved drugs (Fomivirsen and Mipomersen), oligonucleotide-based therapeutics have not yet delivered a clinical drug to the market in the cancer field.
Pedro Miguel Duarte Moreno +3 more
doaj +1 more source
Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review
Biomedicines, 2021 Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA and
Susanne N. Wijesinghe +2 more
doaj +1 more source
Cell, 2019 Stochastic activation of clustered Protocadherin (Pcdh) α, β, and γ genes generates a cell-surface identity code in individual neurons that functions in neural circuit assembly. Here, we show that Pcdhα gene choice involves the activation of an antisense
Daniele Canzio +11 more
semanticscholar +1 more source
Zoonotic Diseases, 2023 Developing novel antiviral agents and approaches is essential for the treatment against human and zoonotic viruses. We had previously produced RNase P-based ribozyme variants capable of efficiently cleaving mRNA in vitro.
Bin Yan +4 more
doaj +1 more source
Molecular Mechanisms of Antisense Oligonucleotides
Nucleic Acid Therapeutics, 2017 In 1987, when I became interested in the notion of antisense technology, I returned to my roots in RNA biochemistry and began work to understand how oligonucleotides behave in biological systems.
S. Crooke
semanticscholar +1 more source
Innovative developments and emerging technologies in RNA therapeutics
RNA Biology, 2022 RNA-based therapeutics are emerging as a powerful platform for the treatment of multiple diseases. Currently, the two main categories of nucleic acid therapeutics, antisense oligonucleotides and small interfering RNAs (siRNAs), achieve their therapeutic ...
François Halloy +10 more
doaj +1 more source
Contribution of Piezo2 to endothelium-dependent pain. [PDF]
, 2015 BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver +3 more
core +2 more sources