Results 171 to 180 of about 83,454 (234)

Glycogen for Smyd3-antisense oligonucleotide delivery and enhanced liver cancer gene therapy. [PDF]

RSC Adv
Bai N, Huang Y, Shen J, Peng Y, Zhang H, Hou D.   +5 more
europepmc   +1 more source

Exosome-Mediated Mitochondrial Delivery of Antisense Oligonucleotides

Nucleic Acid Therapeutics
Dora von Trentini, Ivan J. Dmochowski
openaire   +2 more sources

RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction. [PDF]

Front Mol Biosci
Drongitis D, Verrillo L, de Bellis A, Miano MG.   +3 more
europepmc   +1 more source

MiRNA-based drugs: challenges and delivery strategies. [PDF]

Appl Microbiol Biotechnol
Wang Z, Peng Y, Zhou H, Zhang M, Ju D, Chen Z.   +5 more
europepmc   +1 more source

The Expanding Role of Non-Coding RNAs in Neurodegenerative Diseases: From Biomarkers to Therapeutic Targets. [PDF]

Pharmaceuticals (Basel)
Zhao X, Zheng Y, Cai X, Yao Y, Qin D.
europepmc   +1 more source

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Delivery systems for antisense oligonucleotides

Pharmacology & Therapeutics, 2000
In vitro, the efficacy of the antisense approach is strongly increased by systems delivering oligodeoxyribonucleotides (ODNs) to cells. Up to now, most of the developed vectors favor ODN entrance by a mechanism based on endocytosis. Such is the case for particulate systems, including liposomes (cationic or non-cationic), cationic polyelectrolytes, and ...
C, Garcia-Chaumont, O, Seksek, J, Grzybowska, E, Borowski, J, Bolard   +4 more
openaire   +2 more sources

The delivery of antisense therapeutics

Advanced Drug Delivery Reviews, 2000
Antisense oligonucleotides, ribozymes and DNAzymes have emerged as novel, highly selective inhibitors or modulators of gene expression. Indeed, their use in the treatment of diseases arising from genetic abnormalities has become a real possibility over the past few years. The first antisense drug molecule is now available for clinical use in Europe and
S, Akhtar, M D, Hughes, A, Khan, M, Bibby, M, Hussain, Q, Nawaz, J, Double, P, Sayyed   +7 more
openaire   +2 more sources

Cellular delivery of antisense oligonucleotides

European Journal of Pharmaceutics and Biopharmaceutics, 2000
Antisense oligonucleotides can be successfully employed to inhibit specifically gene expression. However, many oligonucleotide classes are polyanions and cannot passively transit the cell membrane. Thus, the use of naked oligonucleotides for antisense purposes poses some rather stringent challenges, and it is not a trivial task to appropriately ...
I, Lebedeva, L, Benimetskaya, C A, Stein, M, Vilenchik   +3 more
openaire   +2 more sources