Results 181 to 190 of about 1,703,096 (348)

Limited roles of the miR‐17‐92 cluster in the regulation of T‐cell apoptosis

The FEBS Journal, EarlyView.
The pro‐apoptotic protein BIM shapes T‐cell survival and function, but how it is regulated remains unclear. In a mouse model lacking direct miR‐17‐92:Bim interactions, we observed a moderate reduction in Th17 CD4+ T cells. BIM levels were modestly increased in double‐positive thymocytes and naive CD8+ T cells, but this did not affect overall T‐cell ...
Katharina Hoppe, Johannes Woelk, Julia Benz, Sarah Spoeck, William J. Olson, Andreas Villunger, Natascha Hermann‐Kleiter, Verena Labi   +7 more
wiley   +1 more source

Important Aspects of siRNA Design for Optimal Efficacy In Vitro and In Vivo. [PDF]

Int J Cell Biol
Bhakta-Yadav MS, Brown TL.
europepmc   +1 more source

Impact of Electronic Nicotine Delivery Systems on Oral Mucosa: A Cytopathological and Molecular Study

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background The packaging and marketing of electronic cigarettes (e‐cigs) often target younger demographics. This study aimed to evaluate gene expression in e‐cig users through exfoliative cytology. Methods Samples were collected from 17 e‐cig users and 10 nonsmokers as controls.
Alba Pérez‐Jardón, Bruna Fernandes do Carmo Carvalho, Cintia Micaela Chamorro‐Petronacci, Maria Dolores Reboiras‐López, Natalia de Carvalho Faria, Renata Falchete do Prado, Mónica Ghislaine Oliveira Alves, Fábio França Vieira e Silva, Maria‐Elena Padín‐Iruegas, Mario Pérez‐Sayáns, Janete Dias Almeida   +10 more
wiley   +1 more source

Weaknesses out of strength: PNA against the penicillin-binding proteins. [PDF]

Mol Ther Nucleic Acids
Wdowiak M.
europepmc   +1 more source

Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision [PDF]

, 2018
Adak, Sangeeta, Chen, Shiming, Doggett, Teresa, Enright, Jennifer, Hsu, Fong-Fu, Ling, Guoyu, Rajagopal, Rithwick, Semenkovich, Clay F, Shah, Vaishali, Wei, Xiaochao, Yoshino, Jun, Zhang, Sheng   +11 more
core   +2 more sources

Starch Synthase 3 isoforms are essential for normal starch granule initiation in wheat endosperm

New Phytologist, EarlyView.
Summary Wheat grains have two distinct types of starch granules. Large, lenticular A‐type granules are formed from a single initiation per amyloplast during early grain development, while numerous small B‐type granules are initiated during later grain development.
Jinjin Ding, Brendan Fahy, Ryo Matsushima, Qiantao Jiang, David Seung   +4 more
wiley   +1 more source

Systemic distribution of tricyclo-DNA antisense oligonucleotide following intratracheal instillation in the mouse. [PDF]

NAR Mol Med
Laurent J, Deramaudt TB, Cloix R, Robin V, Beley C, Garcia L, Bonay M.   +6 more
europepmc   +1 more source

Development of Modular Geminivirus‐Based Vectors for High Cargo Expression and Gene Targeting in Plants

Plant Biotechnology Journal, EarlyView.
ABSTRACT Viral vectors can be useful tools for expressing recombinant proteins as well as delivering gene‐editing machinery. Despite their utility, the development and subsequent optimisation of these tools is often a difficult and tedious process.
Matthew Neubauer, Katie Vollen, Chengsong Zhao, José T. Ascencio‐Ibáñez, Linda Hanley‐Bowdoin, Anna N. Stepanova, Jose M. Alonso   +6 more
wiley   +1 more source

Precision RNAi in Tomato Using Synthetic Trans‐Acting Small Interfering RNAs Derived From Minimal Precursors

Plant Biotechnology Journal, EarlyView.
ABSTRACT RNA interference (RNAi) is a highly conserved gene silencing mechanism regulating gene expression at transcriptional and post‐transcriptional levels in plants. Synthetic trans‐acting small interfering RNAs (syn‐tasiRNAs) have emerged as powerful tools for highly specific and efficient gene silencing.
Ariel H. Tomassi, María Juárez‐Molina, Adriana E. Cisneros, Ana Alarcia, Francesca Orlando, Sara Toledano‐Franco, Silvia Presa, Antonio Granell, Alberto Carbonell   +8 more
wiley   +1 more source

Application of Antisense Oligonucleotides as an Alternative Approach for Gene Expression Control and Functional Studies. [PDF]

Int J Mol Sci
Szukowska A, Żuk M, Sztompke J, Bednarz B, Kaźmierczak U.   +4 more
europepmc   +1 more source