Results 221 to 230 of about 47,774 (288)

Nanotech meets antibiotics: nucleotide antibiotics delivered by lipid nanoparticles. [PDF]

Front Cell Infect Microbiol
Kim B, Kim D, Ryu CM.
europepmc   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Harnessing CRISPR-dCas13Rx to identify novel antisense targets for therapeutic splicing modulation. [PDF]

Mol Ther Nucleic Acids
Singh RN, Alves CRR.
europepmc   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

RNA Therapeutics in Viral Infections and Cancer: Mechanisms, Challenges, and Prospects: A Review. [PDF]

Pharmaceutics
Generalov E, Shevelev A, Romanov D, Tarasova O, Pozdniakova N.   +4 more
europepmc   +1 more source

Emerging directions in tauopathy research

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of
Luc Buée, Kristin R. Wildsmith, Suvarna Alladi, Taylor Bertucci, Delphine Boche, Kathryn R. Bowles, Adam Boxer, Jennifer Brummet, Sarah L. DeVos, Kristophe Diaz, Anna Jane Dreyer, Karen Duff, Claudia Duran‐Aniotz, Claire S. Durrant, Kurt Farrell, Igor C. Fontana, Nicolai Franzmeier, Bess Frost, Kanta Horie, Petr Kaňovský, Aimee W. Kao, Simin Mahinrad, Maura Malpetti, Huw R. Morris, Carla Palleis, Leonard Petrucelli, Jessica Rexach, Larisa Reyderman, Amy Rommel, James B. Rowe, Sandra M. Sanabria Bohórquez, Chihiro Sato, Michael Schöll, Anja Schneider, Rohan de Silva, Heather M. Snyder, Lawren VandeVrede, Andrew W. Varga, Jacob W. Vogel, Felix L. Yeh, Andrew S. Yoo, Maria C. Carrillo   +41 more
wiley   +1 more source

Long Non-Coding RNAs in HER2-Positive Breast Cancer: From Resistance Mechanisms to Translational Potential. [PDF]

Oncol Res
Vo TH, McNeela E, O'Donnovan O, Prakash Mehta J, Nguyen VH, Rani S.   +5 more
europepmc   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, Volume 99, Issue 6, Page 1571-1588, June 2026.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Therapeutic Innovations for Monkeypox Inhibition. [PDF]

Int J Mol Sci
De N, Bhadra J, Momin MSA, Mitra K, Bhunia D, Sannigrahi A.   +5 more
europepmc   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1552-1566, June 2026.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source