Results 141 to 150 of about 94,605 (281)

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, EarlyView.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Improved targeted delivery of antisense oligonucleotide with an antibody mask. [PDF]

Nucleic Acids Res
Hsia HE, Zanini C, Simonneau C, Fraidling J, Kraft TE, Mayer K, Sommer A, Indlekofer A, Wirth T, Benz J, Georges G, Langer LM, Gassner C, Larraillet V, Lohmann S, Koller E, Mansø M, Ravn J, Hofer K, Emrich T, Niewöhner J, Schumacher F, Brinkmann U.   +22 more
europepmc   +1 more source

Inhibitory effect of PDGFR-α antisense oligonucleotide on the proliferation of rabbit lens epithelial cells in vitro

, 2013
Zhixiang Ding, Yang Chen, Mei-Yuan Qiu, Yuming Zhang, Xin-Sheng Zeng, Yanyi Peng   +5 more
openalex   +2 more sources

Solid-Phase Synthesis\nof Boranophosphate/Phosphorothioate/Phosphate\nChimeric Oligonucleotides and Their Potential as Antisense\nOligonucleotides

, 2021
Yuhei Takahashi (11840365), Kazuki Sato (3597), Takeshi Wada (1524451)   +2 more
openalex   +2 more sources

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, EarlyView.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Generation of sense and antisense oligonucleotides for inhibition of the coat protein gene of the Odontoglossum Ringspot virus in orchid callus tissue : an honors thesis [(HONRS 499)]

, 1997
Audra L. Carroll
openalex   +1 more source

The FsrA‐Mediated Iron‐Sparing Response Regulates the Biosynthesis of the Epipeptide EPE in Bacillus subtilis

Molecular Microbiology, EarlyView.
Under iron‐limited conditions, FsrA base‐pairs with the intergenic region between epeX and epeE, enhancing epeE translation and triggering EPE production. Toxin‐mediated cell lysis releases nutrients, including iron, which can be taken up by surviving cells.
Sarah Miercke, Rabea Ghandour, Kai Papenfort, Thorsten Mascher   +3 more
wiley   +1 more source

Antisense Oligonucleotides [PDF]

, 2020
openaire   +1 more source