Results 141 to 150 of about 102,021 (242)

Casimersen (AMONDYS 45™): An Antisense Oligonucleotide for Duchenne Muscular Dystrophy. [PDF]

Biomedicines
Assefa M, Gepfert A, Zaheer M, Hum JM, Skinner BW.   +4 more
europepmc   +1 more source

NrdR in Streptococcus and Listeria spp.: DNA Helix Phase Dependence of the Bacterial Ribonucleotide Reductase Repressor

Molecular Microbiology, Volume 123, Issue 5, Page 406-419, May 2025.
NrdR in Streptococcus and Listeria spp. regulates the expression of ribonucleotide reductase genes, which produce DNA building blocks. We show that NrdR binds DNA in an ATP/dATP‐dependent manner, and that optimal binding requires an integer number of DNA helix turns between NrdR boxes, with atypically long spacers in Streptococcus pneumoniae.
Saher Shahid, Mateusz Balka, Daniel Lundin, Daniel O. Daley, Britt‐Marie Sjöberg, Inna Rozman Grinberg   +5 more
wiley   +1 more source

Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects. [PDF]

Nat Commun
Leclair NK, Brugiolo M, Park S, Devoucoux M, Urbanski L, Angarola BL, Yurieva M, Anczuków O.   +7 more
europepmc   +1 more source

Alternative Splicing Regulation in Metabolic Disorders

Obesity Reviews, EarlyView.
ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley   +1 more source

Molecular mechanisms and antisense oligonucleotide therapies of familial amyotrophic lateral sclerosis. [PDF]

Mol Ther Nucleic Acids
Al Dera H, AlQahtani B.
europepmc   +1 more source

Offline comprehensive liquid chromatography in combination with a Deoxyribonuclease I immobilized enzymatic reactor for selective screening of oligonucleotide mixtures [PDF]

, 2016
Alvarez Porebski, Piotr Wiktor, Lynen, Frederic   +1 more
core   +1 more source

Natural variation of CsUGT71A60 determines growth and cold tolerance via regulating cytokinin glycosylation in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
Summary Cold stress severely limits tea plant (Camellia sinensis) productivity, yet the molecular mechanisms underlying cold adaptation remain elusive. Here, we identified a cold‐inducible glycosyltransferase, CsUGT71A60, through integrative genome‐wide association studies (GWAS) and proteomic profiling.
Mingyue Zhao, Jingming Wang, Xinyuan Hao, Jieyang Jin, Junwei Tang, Yueyue Wang, Mengting Zhang, Tingting Jing, Wilfried Schwab, Ting Gao, Xinchao Wang, Chuankui Song   +11 more
wiley   +1 more source

CsMYB213‐CsbHLH35 module regulates theanine biosynthesis in tea plants (Camellia sinensis L.)

Plant Biotechnology Journal, EarlyView.
Summary Theanine is a non‐protein free amino acid accumulated in tea plant leaves and makes a major contribution to the unique umami and sweet taste and a multitude of human health benefits of tea. However, its biosynthesis and transcriptional regulation in tea plant leaves remain to be fully understood.
Nianci Xie, Pinqian Zhou, Kuofei Wang, Feiyi Huang, Shuwei Yu, Haiping Fu, Saijun Li, Juan Li, Jian Zhao, Zhonghua Liu, Kunbo Wang   +10 more
wiley   +1 more source

Deep learning facilitates efficient optimization of antisense oligonucleotide drugs. [PDF]

Mol Ther Nucleic Acids
Lin S, Hong L, Wei DQ, Xiong Y.
europepmc   +1 more source

Embracing the future: Neonatal screening for epileptic syndromes

Epilepsia, EarlyView.
Rima Nabbout, Mathieu Kuchenbuch
wiley   +1 more source