Results 161 to 170 of about 94,605 (281)

A sweet barrier to gene silencing: Glucose metabolism interferes with antisense oligonucleotide therapy. [PDF]

Mol Ther Nucleic Acids
Duan S, Zhang W, Cao H.
europepmc   +1 more source

Design of antisense oligonucleotides

Folia Pharmacologica Japonica, 2016
Satoshi, Obika, Yuuya, Kasahara
openaire   +3 more sources

Antisense Oligonucleotides Delivered to the Mouse CNS Ameliorate Symptoms of Severe Spinal Muscular Atrophy

, 2011
Marco A. Passini, Jie Bu, Amy M. Richards, Cathrine Kinnecom, S. Pablo Sardi, Lisa M. Stanek, Yimin Hua, Frank Rigo, John Matson, Gene Hung, Edward M. Kaye, Lamya S. Shihabuddin, Adrian R. Krainer, C. Frank Bennett, Seng H. Cheng   +14 more
openalex   +2 more sources

ZmMYB127 Modulates Maize Kernel Texture and Size by Integrating the Synthesis of Starch, Zein Proteins and Auxin

Plant Biotechnology Journal, EarlyView.
ABSTRACT Kernel texture is an important agronomic trait that determines the end‐uses of maize kernels and affects their integrity at harvest and susceptibility to pests and diseases. The ratio of the vitreous endosperm (RVE) is the key index for assessing kernel texture, and identifying key genes involved in its formation is crucial for maize breeding.
Tiandan Long, Yayun Wang, Zhou Liu, Yongbin Wang, Changqing Mao, Dening Wang, Aying Qin, Qiang Liao, Jin Yang, Xiujun Fan, Lei Gao, Yufeng Hu, Jing Wang, Yubi Huang, Yangping Li   +14 more
wiley   +1 more source

CsYABBY1 and CsMYB114 Enhance Acquired Drought Tolerance by Mediating Flavonoid Biosynthesis in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Drought priming is a critical agronomic strategy for enhancing plant drought tolerance, yet the optimal priming intensity and transcriptional regulatory mechanisms underlying subsequent drought responses in the tea plant (Camellia sinensis) remain poorly characterised.
Caiyun Tian, Chengzhe Zhou, Shengjing Wen, Cheng Zhang, Anru Zheng, Lele Jiang, Niannian Yang, Zhuo Tang, Xiaowen Hu, Zhendong Zhang, Jiaxin Fang, Zhong Wang, Yuqiong Guo   +12 more
wiley   +1 more source

A therapeutic antisense oligonucleotide encompassing 2'-<i>O</i>-methoxyethyl modification triggers unique perturbation of the transcriptome. [PDF]

NAR Mol Med
Ottesen EW, Murzyn WA, Kaas RL, Bertrand KJ, Payne JL, Singh RN.   +5 more
europepmc   +1 more source

Precision RNAi in Tomato Using Synthetic Trans‐Acting Small Interfering RNAs Derived From Minimal Precursors

Plant Biotechnology Journal, EarlyView.
ABSTRACT RNA interference (RNAi) is a highly conserved gene silencing mechanism regulating gene expression at transcriptional and post‐transcriptional levels in plants. Synthetic trans‐acting small interfering RNAs (syn‐tasiRNAs) have emerged as powerful tools for highly specific and efficient gene silencing.
Ariel H. Tomassi, María Juárez‐Molina, Adriana E. Cisneros, Ana Alarcia, Francesca Orlando, Sara Toledano‐Franco, Silvia Presa, Antonio Granell, Alberto Carbonell   +8 more
wiley   +1 more source

Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia [PDF]

, 2002
Guido Marcucci, John C. Byrd, Guowei Dai, Marko I. Klisovic, Peter J. Kourlas, Donn C. Young, Spero R. Cataland, Diane B. Fisher, David A. Lucas, Kenneth K. Chan, Pierluigi Porcu, Zhong-Pin Lin, Sherif F. Farag, Stanley R. Frankel, James A. Zwiebel, Eric H. Kraut, Stanley P. Balcerzak, Clara D. Bloomfield, Michael R. Grever, Michael A. Caligiuri   +19 more
openalex   +1 more source

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum

Plant Biotechnology Journal, EarlyView.
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Qianle Zhang, Qingwen Wu, Wenjing Shi, Yinai Deng, Ruoting Zhan, Dongming Ma   +5 more
wiley   +1 more source

Suppression of Bcl-2 by Antisense Oligonucleotides Results in Compensation and Enhanced Tumor Proliferation Involving KI-67 [PDF]

, 2015
Marvin Rubenstein
openalex   +1 more source