Results 161 to 170 of about 102,021 (242)

The history of Down syndrome–associated Alzheimer's disease; past, present, and future

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract The landscape of Down syndrome–associated Alzheimer's disease (DSAD) research reflects decades of scientific endeavor and collaborative effort, charting a remarkable journey from initial observations to the elucidation of complex genetic and molecular mechanisms.
Lucia Maure‐Blesa, María Carmona‐Iragui, Ira Lott, Elizabeth Head, Thomas Wisniewski, Michael S. Rafii, Joaquín Espinosa, Jesús Flórez, William C. Mobley, Anthony Holland, André Strydom, Shahid Zaman, Juan Fortea   +12 more
wiley   +1 more source

Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice. [PDF]

Cardiovasc Res
Modder M, Het Panhuis WI, Li M, Afkir S, Dorn AL, Pronk ACM, Streefland TCM, Lalai RA, Pierrou S, Nilsson SK, Olivecrona G, Kooijman S, Rensen PCN, Schönke M.   +13 more
europepmc   +1 more source

Brain Metabolic Features of FUS‐ALS: A 2‐[18F]FDG‐PET Study

Annals of Neurology, Volume 97, Issue 6, Page 1134-1143, June 2025.
Objective We aimed at evaluating the brain metabolic features of fused in sarcoma amyotrophic lateral sclerosis (FUS‐ALS) compared with sporadic ALS (sALS), using 2‐[fluorine‐18] fluoro‐2‐deoxy‐D‐glucose positron emission tomography (2‐[18F]FDG‐PET). Methods We employed the 2‐sample t‐test model of SPM12, implemented in MATLAB, to compare 12 FUS‐ALS ...
Antonio Canosa, Umberto Manera, Rosario Vasta, Grazia Zocco, Francesca Di Pede, Sara Cabras, Filippo De Mattei, Francesca Palumbo, Barbara Iazzolino, Emilio Minerva, Luca Sbaiz, Maura Brunetti, Salvatore Gallone, Maurizio Grassano, Enrico Matteoni, Giulia Polverari, Giuseppe Fuda, Federico Casale, Paolina Salamone, Giovanni De Marco, Giulia Marchese, Cristina Moglia, Andrea Calvo, Marco Pagani, Adriano Chiò   +24 more
wiley   +1 more source

Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment. [PDF]

Biomolecules
Sun F, Wang H, Wu J, Quraishi IH, Zhang Y, Pedram M, Gao B, Jonas EA, Nguyen V, Wu S, Mabrouk OS, Jafar-Nejad P, Kaczmarek LK.   +12 more
europepmc   +1 more source

PUF60‐Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background As an essential transcription factor, Myc‐associated zinc‐finger protein (MAZ) is frequently upregulated in many human tumors and is a well‐documented oncogene. However, we found high expression of MAZ was closely associated with good survival outcomes in patients with stomach adenocarcinoma (STAD), and the underlying mechanism ...
Dong Xing, Ting Zhao, Chenchen Mao, Zheng Han, Wanxia Cai, Teming Zhang, Dianfeng Mei, Wangkai Xie, Jiaye Yu, Zhonghan Wu, Zhiyuan Chen, Shiyu Feng, Xian Shen, Xiangyang Xue, Dan Xiang   +14 more
wiley   +1 more source

Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2) [PDF]

, 2018
et al,, Picus, Joel
core   +1 more source

Peptide–Oligonucleotide Conjugates: Catalytic Preparation in Aqueous Solution or On‐Column

Current Protocols, Volume 5, Issue 6, June 2025.
Abstract Peptide–oligonucleotide conjugates (POCs) are synthesized through a novel catalytic and sustainable approach. The amide coupling between peptide and oligonucleotide is facilitated by 1,4‐diazabicyclo[2.2.2]octane (DABCO) as catalyst and 2‐chloro‐4,6‐dimethoxy‐1,3,5‐triazine (CDMT) as a stoichiometric activating agent.
Marion Gras, Michael Smietana, Pauline Adler   +2 more
wiley   +1 more source

Preparing for Patient-Customized N-of-1 Antisense Oligonucleotide Therapy to Treat Rare Diseases. [PDF]

Genes (Basel)
Wilton-Clark H, Yan E, Yokota T, Yokota T.   +3 more
europepmc   +1 more source

New horizons in the pharmacological management of venous thromboembolism

HemaSphere, Volume 9, Issue 6, June 2025.
Abstract Many patients suffer from venous thromboembolism (VTE) and its consequences. Despite substantial advancements with the introduction of direct oral anticoagulants (DOACs), patients and clinicians still encounter challenges in the acute and long‐term management of VTE, such as recurrent events, anticoagulant‐related bleeding complications, and ...
Andreas Verstraete, Quentin Van Thillo, Thomas Vanassche, Peter Verhamme   +3 more
wiley   +1 more source

Beyond Conventional Approaches: The Revolutionary Role of Nanoparticles in Breast Cancer

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
This review explores integrated approach of nanotechnology to breast cancer diagnosis and treatment. We highlight imaging techniques for tumor detection and biomarker analysis in biological samples for early diagnosis. Advanced therapies, including targeted drug delivery and antibody‐drug conjugates, enable precise medication transport to cancer cells,
Mohan Liu, Yusi Wang, Yan Li, Yibing Zhang, Bailing Zhou, Lei Yang, Xi Yan, Li Yang   +7 more
wiley   +1 more source