Results 181 to 190 of about 94,605 (281)

Development of Locked Nucleic Acid Antisense Oligonucleotides Targeting Ebola Viral Proteins and Host Factor Niemann-Pick C1

, 2018
Jessica Chery, Andreas Petri, Alexandre Wagschal, Sun-Young Lim, James M. Cunningham, Shobha Vasudevan, Sakari Kauppinen, Anders M. Näär   +7 more
openalex   +2 more sources

The MdERF17–MdbHLH149 Module Mediates Ethylene‐Induced Starch Degradation Through the Transcriptional Repression of α‐Amylase MdAMY1 in Apple

Plant Biotechnology Journal, EarlyView.
ABSTRACT The ripening of climacteric fruits is characterised by a sharp increase in ethylene production, coinciding with the conversion of starch into soluble sugars. However, the regulatory interplay between ethylene and starch degradation in apple remains largely unclear. Here, we report a negative correlation between starch accumulation and ethylene
Fan Xiao, Chu‐Kun Wang, Jiu‐Cheng Zhang, Xin‐Yue Jian, Ying Xiang, Wang‐Jiang Zhang, Jin‐Chao Meng, Wen‐Yan Wang, Da‐Gang Hu   +8 more
wiley   +1 more source

Comparison of <i>MALAT1</i> antisense oligonucleotide distribution following intracerebroventricular and lumbar intrathecal routes of administration. [PDF]

Mol Ther Nucleic Acids
Boyd MM, Mazur C, Pribnow K, Zanon RL, Adams E, DuGal J, Klein SK, Shafer LL.   +7 more
europepmc   +1 more source

Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten disease. [PDF]

Nucleic Acids Res
Stratton MP, Centa JL, Swier VJ, Pfeifer WL, Booth CD, Albert K, Hunyara JL, Rechtzigel MJ, Duelli FJ, Leppert HG, Rigo F, Smit T, Jafar-Nejad P, Weimer JM, Drack AV, Hastings ML.   +15 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies.
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Evaluation of Multiple-Turnover Capability of Locked Nucleic Acid Antisense Oligonucleotides in Cell-Free RNase H-Mediated Antisense Reaction and in Mice

, 2014
Tsuyoshi Yamamoto, Naoko Fujii, Hidenori Yasuhara, Shunsuke Wada, Fumito Wada, Naoya Shigesada, Mariko Harada‐Shiba, Satoshi Obika   +7 more
openalex   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

<i>In vivo</i> delivery of a fluorogenic antisense oligonucleotide into human leukocytes in a humanized mouse model system. [PDF]

Mol Ther Methods Clin Dev
Seidel NB, Rout SS, Packard BZ, Lavender KJ.   +3 more
europepmc   +1 more source

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

Glia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean J. Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed Hassan Farah, Jeffrey D. Rothstein   +9 more
wiley   +1 more source

Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux. [PDF]

Int J Oral Sci
Ni N, Wang M, Yuan Z, Zhang L, Cai J, Du Q, Li P, Gao C, Zhang H, Li Y, Yuan H.   +10 more
europepmc   +1 more source