Results 221 to 230 of about 94,605 (281)

Anti-TNF-α antisense-oligonucleotide-conjugated PLG nanoparticles protect transplanted islets. [PDF]

Mol Ther Methods Clin Dev
Bealer EJ, Padgaonkar N, Crumley K, Saito E, Beekman Z, DeKorte A, Prakash TP, Revenko A, Shea LD.   +8 more
europepmc   +1 more source

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Antisense oligonucleotide-mediated upregulation of <i>Jag1</i> ameliorates liver disease phenotypes in a mouse model of Alagille syndrome. [PDF]

Mol Ther Nucleic Acids
Zhang L, Niknejad N, Li J, Peng L, Jain S, Steiner D, Thai R, Yu XX, Wang Y, Liang XH.   +9 more
europepmc   +1 more source

Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li, Pushpa Dhilipkannah, Van K Holden, Ashutosh Sachdeva, Feng Jiang   +4 more
wiley   +1 more source

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment. [PDF]

Beilstein J Nanotechnol
Alvarez AC, Maguire D, Brannigan RP.
europepmc   +1 more source

Ythdc1‐p300‐Klf5 Complex‐Mediated Golgi Dysfunction Promotes Aortic Aneurysm

Advanced Science, Volume 13, Issue 4, 19 January 2026.
In their Research Article (DOI: https://doi.org/10.1002/advs.202512116* lF: 14.1 Q1), Wenli Wang and co‐workers identifies a novel lncRNA m6A modification‐dependent regulatory mechanism of vascular homeostasis, and constructs a predictive model for post‐operative short‐term death based on AD patient's features, providing a platform to be able to ...
Wen‐Li Wang, Zhi‐Xue Song, Si‐Ming Bu, Yi‐Mei Liu, Qing Li, Wen‐Xia Zhang, Xu‐Rong Sun, Xin Zhang, Yu‐Xuan Xiao, Di Bo, Xu‐Bin Miao, Chao Liu, Xin‐Hua Zhang, Lei Zheng, Hong‐Ye Zhao, Bao‐Lian Zhang, Wen Jia, Kui Chi, Yu Liu, Yong‐Bo Zhao, Bin Zheng, Dong Ma, Jin‐Kun Wen   +22 more
wiley   +1 more source

Consensus guidelines for assessing eligibility of pathogenic DNA variants for antisense oligonucleotide treatments. [PDF]

Am J Hum Genet
Cheerie D, Meserve MM, Beijer D, Kaiwar C, Newton L, Taylor Tavares AL, Verran AS, Sherrill E, Leonard S, Sanders SJ, Blake E, Elkhateeb N, Gandhi A, Liang NSY, Morgan JT, Verwillow A, Verheijen J, Giles A, Williams S, Chopra M, Croft L, Dafsari HS, Davidson AE, Friedman J, Gregor A, Haque B, Lechner R, Montgomery KA, Ryten M, Schober E, Siegel G, Sullivan PJ, Whittle EF, Zardetto B, Yu TW, Synofzik M, Aartsma-Rus A, Costain G, Lauffer MC, N=1 Collaborative.   +39 more
europepmc   +1 more source

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
wiley   +1 more source

An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome. [PDF]

Elife
Thakur P, Lackinger M, Diamantopoulou A, Rao S, Chen Y, Khalizova K, Ferng A, Mazur C, Kordasiewicz H, Shprintzen RJ, Markx S, Xu B, Gogos JA.   +12 more
europepmc   +1 more source