Results 221 to 230 of about 266,614 (380)

Identification and characterization by antisense oligonucleotides of exon and intron sequences required for splicing.

, 1994
Z Dominski, Ryszard Kole
openalex   +1 more source

Sustained reduction of neointima with c-myc antisense oligonucleotides in saphenous vein grafts [PDF]

, 1998
John D. Mannion, Michael L. Ormont, Michael G. Magno, James E. O’Brien, Yi Shi, Andrew Zalewski   +5 more
openalex   +1 more source

Polyethylene Glycol‐Functionalized Graphene Oxide Nanocomposites: Advances in Biomedical Applications

Nano Select, EarlyView.
Polyethylene glycol‐functionalized graphene oxide (PEG‐GO) nanocomposites revolutionize nanomedicine with their high surface area and tunable properties. This review explores their synthesis, characterization, and applications in drug delivery, gene therapy, biosensing, and photothermal therapy.
Oluwasegun Chijioke Adekoya, Gbolahan Joseph Adekoya, Williams Kehinde Kupolati, Yskandar Hamam, Rotimi Emmanuel Sadiku   +4 more
wiley   +1 more source

In Vitro Structure-Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases. [PDF]

Pharmacol Res Perspect
Lovrić J, Yan J, Li X, Karlsborn T, Bood M, Dahlén A, Hilgendorf C, Bhatt DK.   +7 more
europepmc   +1 more source

Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides.

, 1993
Z. Dominski, R. Kole
openalex   +2 more sources

Control of two sucking insect pests, a whitefly (Bemisia tabaci) and a thrips (Frankliniella occidentalis), infesting hot peppers by spraying LDH‐formulated dsRNA

Pest Management Science, EarlyView.
A vacuolar type ATPase subunit B (vATPase‐B) gene is identified and expressed in the midgut of Bemisia tabaci and Frankliniella occidentalis. The double‐stranded RNA (dsRNA) specific to vATPase‐B was expressed in hot peppers by virus‐induced gene silencing (VIGS) and killed both whitefly and thrips.
Falguni Khan, Tae‐Geun Song, Yonggyun Kim   +2 more
wiley   +1 more source

Antisense oligonucleotide therapy for patients with Friedreich's ataxia carrying the c.165+5G>C splicing mutation. [PDF]

Mol Ther Nucleic Acids
Yameogo P, Aguilar S, Prakash TP, Rigo F, Lynch DR, Napierala JS, Napierala M.   +6 more
europepmc   +1 more source

Suppression of Gal.ALPHA.1-3Gal expression by antisense oligonucleotides specific for porcine .ALPHA.-1,3-galactosyltransferase mRNA treatment.

, 1998
Akiko Taguchi, Masanobu Arita, Yasunori Kushi, Shizuo Handa   +3 more
openalex   +2 more sources

Inhibition of the erbB-2 Tyrosine Kinase Receptor in Breast Cancer Cells by Phosphoromonothioate and Phosphorodithioate Antisense Oligonucleotides [PDF]

, 1996
James P. Vaughn, J. Stekler, Samuel H. Demirdji, Jane K. Mills, Marvin H. Caruthers, J. Dirk Iglehart, Jeffrey R. Marks   +6 more
openalex   +1 more source

A Case Study of Model‐Informed Drug Development of a Novel PCSK9 Antisense Oligonucleotide. Part 2: Phase 2 to Phase 3

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT In this second part of a case study on the practical use of model‐informed drug development (MIDD), we describe the clinical development of AZD8233, a novel proprotein convertase subtilisin/kexin type 9 (PCSK9) antisense oligonucleotide, from phase 2b to the start of phase 3.
Jane Knöchel, Catarina Nilsson, Björn Carlsson, Alexis Hofherr, Per Johanson, Tina Rydén‐Bergsten, Bengt Hamrén, Dinko Rekić   +7 more
wiley   +1 more source