Results 211 to 220 of about 124,170 (327)

Deciphering SCN2A: A comprehensive review of rodent models of Scn2a dysfunction

Epilepsia, EarlyView.
Abstract SCN2A encodes for the alpha subunit of the voltage‐gated sodium channel NaV1.2, which is involved in action potential initiation and backpropagation in excitatory neurons. Currently, it is one of the highest monogenetic risk factors for both epilepsy and autism spectrum disorder.
Katelin E. J. Scott, Maria Fernanda Hermosillo Arrieta, Aislinn J. Williams   +2 more
wiley   +1 more source

<i>SNORA13</i> antisense oligonucleotides enhances the therapeutical effects of 5-fluorouracil in colon adenocarcinoma. [PDF]

Front Pharmacol
Wang Y, An H, Zhang Y, Lyu QR, Zhang Z.
europepmc   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Antisense oligonucleotides targeting the SARS-CoV-2 nucleocapsid gene decrease viral titers in hamsters. [PDF]

Mol Ther Nucleic Acids
Fitzpatrick C, Meunier N, Lepoder S, Dhorne-Pollet S, Da Costa B, Klonjkowki B, Eléouët JF, Burzio VA, Delmas B, Barrey E.   +9 more
europepmc   +1 more source

Blood group O expression in normal tissues and tumors

The FEBS Journal, EarlyView.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin, Lukas Muerner, Tanya R. McKitrick, Catherine A. Tilton, Lauren E. Pepi, Tianwei Jia, Maxence Noel, Leon Y. Zheng, Sean R. Stowell, Stephan von Gunten, Jamie Heimburg‐Molinaro, Richard D. Cummings   +11 more
wiley   +1 more source

Lipid Nanovesicles in Cancer Treatment: Improving Targeting and Stability of Antisense Oligonucleotides. [PDF]

Drug Des Devel Ther
Ding HY, Zhou H, Jiang Y, Chen SS, Wu XX, Li Y, Luo J, Zhang PF, Ding YN.   +8 more
europepmc   +1 more source

The effect of bcr-abl antisense oligonucleotide on DNA synthesis and apoptosis in K562 chronic myeloid leukemia cells

, 1996
Peter T. Rowley, Peter C. Keng, Barbara A. Kosciolek   +2 more
openalex   +1 more source

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids [PDF]

, 2000
Claes Wahlestedt, Peter Salmi, Liam Good, Johanna Kela, Thomas Johnsson, Tomas Hökfelt, Christian Broberger, Frank Porreca, Josephine Lai, Kunkun Ren, Michael H. Ossipov, Alexei A. Koshkin, Nana Jakobsen, Jan Skouv, Henrik Oerum, Mogens Havsteen Jacobsen, Jesper Wengel   +16 more
openalex   +1 more source

A Small RNA Derived From the 5′ End of the IS200 tnpA Transcript Regulates Multiple Virulence Regulons in Salmonella typhimurium

Molecular Microbiology, EarlyView.
We show deletion of an IS200‐encoded sRNA (5′tnpA) in Salmonella impacts the expression of SPI‐1, flagellar, cysteine, and phsABC regulons. Evidence is presented that, with regard to the SPI‐1 regulon, 5′tnpA may function through base pairing with another sRNA known to regulate SPI1 called PinT.
Ryan S. Trussler, Naomi‐Jean Q. Scherba, Hoda Kooshapour, Michael J. Ellis, Konrad U. Förstner, Matthew Albert, Alexander J. Westermann, David B. Haniford   +7 more
wiley   +1 more source

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides. [PDF]

Neurobiol Dis
Loreto A, Cramb KML, McDermott LA, Antoniou C, Cirilli I, Caiazza MC, Merlini E, Arthur-Farraj P, du Preez WD, Mock ED, Zhao HT, Bennett DL, Orsomando G, Coleman MP, Wade-Martins R.   +14 more
europepmc   +1 more source