Results 251 to 260 of about 275,477 (365)

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, Volume 12, Issue 25, July 3, 2025.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases

Neuron, 2017
Kathleen M. Schoch, T. Miller
semanticscholar   +1 more source

In Situ and Real‐Time Multi‐Modality Imaging Guided Orderly Triple‐Therapy of Tumors with a Multifunctional Nanodrug

Advanced Science, Volume 12, Issue 25, July 3, 2025.
A multifunctional AuNR@SiO2@MnO2@ DNA prodrugs (ASMD) nanodrug is designed to establish an in situ and real‐time photoacoustic (PA)/magnetic resonance (MR)/fluorescence (FL) multi‐modality imaging guided orderly photothermal therapy (PTT)/chemodynamic therapy (CDT)/gene therapy (GT) triple‐therapy of tumor.
Chaoyi Yang, Yuexuan Meng, Ying An, Jing Jia, Yuru Wang, Guangming Li, Yiran Li, Shan Wu, Chengyao Geng, Yunlong Chen, Huangxian Ju   +10 more
wiley   +1 more source

Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference. [PDF]

Front Endocrinol (Lausanne)
Golounina O, Minniakhmetov I, Salakhov R, Khusainova R, Zakharova E, Bychkov I, Mokrysheva N.   +6 more
europepmc   +1 more source

Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION The Down syndrome‐associated Alzheimer's disease (DSAD) autosomal dominant Alzheimer's disease (ADAD) 2024 Conference in Barcelona, convened under an Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) grant through the Down syndrome and Alzheimer's disease (AD) Professional ...
Neus Falgàs, Lucia Maure‐Blesa, Beau Ances, Lisi Flores‐Aguilar, Sigan Hartley, Jason Hassenstab, M Florencia Iulita, Matthew Janicki, Katherine Koenig, Patrick Lao, Johannes Levin, Eric McDade, Laurent Meijer, Michael S. Rafii, Heather M. Snyder, Raquel Sánchez‐Valle, Juan Fortea, DSAD‐ADAD conference group, Jose Arriola Infante, Mirea Balasa, Isabel Barroeta, Nicolas Barthelemy R, Alexandre Bejanin, Bessy Benejam, Beatriz Bosch, Angela Bradshaw, Maria Carmona‐Iragui, Ann Cohen, Aina Comas Albertí, Lajos Csincsik, A. Claudio Cuello, Laura del Hoyo Soriano, Janna Dijkstra, Natalie Edwards, Sandra Giménez, Fernando Gonzalez‐Ortiz, Brian Gordon, Sara Gutiérrez Fernández, Benjamin Handen, Charlotte Jacob, Erik Johnson, Charlotte Johansson, Albert Lladó, Alberto Lleó, Samuel Morabito, Alejandra. O. Morcillo‐Nieto, Laia Montoliu‐Gaya, Michael Okafor, Agnes Pérez‐Millan, Marie Claude Potier, John Ringman, Íñigo Rodríguez‐Baz, Eric Rubenstein, Natalie S. Ryan, André Strydom, Lidia Vaqué‐Alcázar, Lisa Vermunt, Laura Videla Toro, Shahid Zaman   +58 more
wiley   +1 more source

Inhibition of Antigen-Induced Eosinophilia and Late Phase Airway Hyperresponsiveness by an IL-5 Antisense Oligonucleotide in Mouse Models of Asthma [PDF]

, 2000
James G. Karras, Kathy McGraw, Robert A. McKay, Scott Cooper, Dmitri Lerner, Tao Lü, Christoph Walker, Nicholas M. Dean, Brett P. Monia   +8 more
openalex   +1 more source

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides.

Advanced Drug Delivery Reviews, 2015
R. Geary, D. Norris, R. Yu, C. Bennett
semanticscholar   +1 more source

Personalized allele-specific antisense oligonucleotides for GNAO1-neurodevelopmental disorder. [PDF]

Mol Ther Nucleic Acids
Shomer I, Mor N, Raviv S, Budick-Harmelin N, Matchevich T, Avkin-Nachum S, Rais Y, Haffner-Krausz R, Haimovich A, Ziv A, Fluss R, Ben-Ze'ev B, Heimer G, Silachev DN, Katanaev VL, Dominissini D.   +15 more
europepmc   +1 more source

Fluoxetine Treatment in Epilepsy of Infancy with Migrating Focal Seizures Due to KCNT1 Variants: An Open Label Study

Annals of Neurology, Volume 98, Issue 1, Page 48-61, July 2025.
Objective Gain‐of‐function (GoF) variants in KCNT1 encoding for potassium channels are associated with different epilepsy phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), other early infantile developmental and epileptic encephalopathies, and focal epilepsy.
Marina Trivisano, Ilaria Mosca, Licia Salimbene, Angela De Dominicis, Paolo Ambrosino, Deborah Puzo, Ilenio Servettini, Cinzia Correale, Chiara Falamesca, Cristina Filosomi, Bianca Goffredo, Maria Virginia Soldovieri, Maurizio Taglialatela, Nicola Specchio   +13 more
wiley   +1 more source

Antisense oligonucleotides targeted against protein kinase c α inhibit proliferation of cultured avian myoblasts [PDF]

, 2000
Daniela Andrea Capiati, Guillermo Vázquez, María T. Tellez de Iñon, R. Boland   +3 more
openalex   +1 more source