Results 251 to 260 of about 127,002 (321)

The diversity of SNCA transcripts in neurons, and its impact on antisense oligonucleotide therapeutics [PDF]

James R. Evans, Emil K. Gustavsson, Ivan Doykov, David Murphy, Gurvir S. Virdi, Joanne Lachica, Alexander Röntgen, Mhd Hussein Murtada, Chun Wei Pang, Hannah Macpherson, Anna I. Wernick, Christina E. Toomey, Dilan Athauda, Minee L. Choi, John Hardy, Nicholas Wood, Michele Vendruscolo, Kevin Mills, Wendy Heywood, Mina Ryten, Sonia Gandhi   +20 more
openalex   +1 more source

Mitochondrial Transporter ABCB10 Protects Against Doxorubicin‐Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Doxorubicin (DOX) is a highly effective chemotherapeutic agent whose use can cause respiratory toxicity, increasing patient fatigue and negatively impacting quality of life and survival. These adverse effects occur due to diaphragm muscle mitochondrial accumulation of DOX, where it causes reactive oxygen species production and iron ...
Ashley J. Smuder, Vivian Doerr, Cesar E. Jacintho Moritz, Jie Li, Branden L. Nguyen   +4 more
wiley   +1 more source

Targeting FANCM by antisense oligonucleotides in ALT-positive cancers. [PDF]

Mol Ther Nucleic Acids
Tieo G, Bao Ying Lim N, Lim KW, Dröge P, Phan AT, Jeitany M.   +5 more
europepmc   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała, Marta Białobrzeska, Józef Dulak, Urszula Florczyk‐Soluch   +3 more
wiley   +1 more source

Extracellular Vesicle‐Mediated Delivery of Constrained Peptides Disrupts the Pathogenic Interaction of LRRK2‐FADD in Parkinson's Disease

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT The interaction between mutated leucine‐rich repeat kinase 2 (LRRK2) and the death adaptor protein FADD accounts for apoptotic death of dopaminergic neurons in familial Parkinson's disease (PD) driven by LRRK2 mutations. Disrupting this pathogenic interaction using constrained peptides is a promising therapeutic strategy to mitigate apoptotic ...
Yaochao Zheng, Brian Joseph Jurgielewicz, Leah G Helton, Hardy J Rideout, Eileen J. Kennedy, Steven L Stice, Yao Yao   +6 more
wiley   +1 more source

Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides. [PDF]

J Am Chem Soc
Kashyap D, Cadeddu M, Oliver PL, Milne TA, Booth MJ.   +4 more
europepmc   +1 more source

Intracerebral microinjection of antisense oligonucleotides directed against G protein α subunits and morphine antinociception

, 1997
Ken Kitamura, Masanobu Yoshikawa, Masayuki Kanai, Takao Taniguchi, Kazuhito Akahori, Kouichi Yokoeami, Kayoko Iwao, Tetsuo Oka   +7 more
openalex   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

<i>SNORA13</i> antisense oligonucleotides enhances the therapeutical effects of 5-fluorouracil in colon adenocarcinoma. [PDF]

Front Pharmacol
Wang Y, An H, Zhang Y, Lyu QR, Zhang Z.
europepmc   +1 more source

Hydrogels for Cancer Immunotherapy: Strategies From Construction to Application

MedComm, Volume 7, Issue 2, February 2026.
Hydrogels offer an innovative platform for cancer immunotherapy. Through tailorable crosslinking strategies, they form customizable drug delivery platforms that address diverse therapeutic requirements by loading specific immunotherapeutic agents. These systems demonstrate significant clinical potential for precise tumor immunotherapy.
Xiaohua Chen, Shan Wu, Yueyang Zhang, Lilu Feng, Yang Chen, Xuzhao Yang, Ke Men, Jiuqun Zhu, Ming Li   +8 more
wiley   +1 more source