Results 261 to 270 of about 125,197 (343)

Antisense oligonucleotides targeting valosin-containing protein ameliorate muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy. [PDF]

Clin Transl Med
Pal P, Carrer M, Weiss L, Jaime OG, Cheng C, Shmara A, Boock V, Bosch D, Youssef M, Fazeli Y, Afetian M, Grossman TR, Hicks MR, Jafar-Nejad P, Kimonis V.   +14 more
europepmc   +1 more source

Urine‐Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Urine epithelial cells from Dravet syndrome (DS) patients carrying distinct SCN1A variants were reprogrammed into induced pluripotent stem cells (iPSCs) and differentiated into neural stem cells (NSCs) to generate patient‐derived neurospheres. Three neurosphere lines were analyzed in biological triplicates using isobaric quantitative proteomics ...
Michele Martins, Guillaume Nugue, Andrey Aguiar, Leticia R. Q. Souza, Paulo V. Abrantes, Julia Rodrigues Trajano, Mariana Stelling, Magno Junqueira, Stevens Rehen, Marília Zaluar P. Guimarães   +9 more
wiley   +1 more source

Liver-specific delivery of MDM2 antisense oligonucleotides counteracts diet-induced metabolic-dysfunction-associated steatotic liver diseases. [PDF]

Mol Ther Nucleic Acids
Hoque MM, Kong M, Yuan X, Zhou X, Ting-Yuan Yeh S, Long K, Lin H, Yip Cheng KK.   +7 more
europepmc   +1 more source

Fascinating single‐cell red algae: models for evolution and adaptation

New Phytologist, Volume 250, Issue 3, Page 1424-1437, May 2026.
Summary The unicellular red algae, Cyanidiophyceae, that diverged early during Archaeplastida (algal and plant) evolution, occupy a variety of extreme habitats that are inhospitable for most other eukaryotes. With the use of modern genomics and genetics methods, Cyanidiophyceae show a remarkable taxonomic diversity, share haplodiplophasic life cycles ...
Frédéric Berger, Debashish Bhattacharya, Chung Hyun Cho, Seok‐Wan Choi, Julia Van Etten, Shunsuke Hirooka, Tzu‐Yen Huang, Kyle J. Lauersen, Yongsung Lee, Shao‐Lun Liu, Shin‐ya Miyagishima, Stephen D. Rader, Daniel Schubert, Hwan Su Yoon   +13 more
wiley   +1 more source

Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA-Charge Neutral Linkages for Enhanced Splice-Switching Antisense Oligonucleotides. [PDF]

Angew Chem Int Ed Engl
Kennett A, Lie L, Flerin M, Kurt BZ, Baker YR, Hill AC, Ramesh A, Wood MJA, Dhara D, El-Sagheer AH, Duarte F, Brown T.   +11 more
europepmc   +1 more source

Rare Natural SNP Activates SHOOT APICAL MERISTEM ENLARGER1 to Increase Branch Number and Silique Number on the Main Inflorescence in Brassica napus

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2768-2786, May 2026.
ABSTRACT Brassica napus is the second most important oil crop worldwide. Number of primary branches (Branch number, BN) and silique number on the main inflorescence (SMI) are key yield‐related quantitative traits. Here, we cloned a major QTL, qDB.A09, which simultaneously influences BN and SMI.
Sihao Zhang, Bao Li, Xiaoting Li, Song Yu, Yebitao Yang, Peipei Liu, Tanglingdian He, Wei Wang, Mei Li, Liang Guo, Jinxing Tu   +10 more
wiley   +1 more source

The 10–23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
This review focuses on the 10–23 DNAzyme in diagnostics, spanning unregulated and regulated target‐recognition modes, and their functionalization across colorimetric, fluorescent, electrochemical, electrochemiluminescent, and intracellular biosensing strategies.
Connor Nurmi, Jake Brill, Sanne Roumans, Amal Mathai, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

Rbm20 antisense oligonucleotides alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure (HFpEF). [PDF]

Cardiovasc Res
Methawasin M, Meinke S, Radke MH, Farman GP, Hourani Z, Smith JE, Guo W, Granzier H, Gotthardt M.   +8 more
europepmc   +1 more source

Transcription Profiling of Potato Leaves in Response to Heat Stress at Single‐Cell Resolution

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2970-2987, May 2026.
ABSTRACT Potato (Solanum tuberosum L.) is a globally important food crop with considerable nutritional and economic value. Heat stress significantly inhibits potato plant growth and tuber development, constraining the sustainable development of the potato industry. Currently, studies on the cellular‐level mechanisms underlying heat adaptation in potato
Shiqi Wen, Ke Wang, Wenqian Liang, Rongrong Liu, Zihan Li, Xinlong Chen, Yan Li, Dianqiu Lv, Hongju Jian   +8 more
wiley   +1 more source

The impact of chemical modifications of antisense oligonucleotides on CTX-M-15 β-lactamase target affinity and expression of ceftriaxone-resistant <i>Escherichia coli</i>. [PDF]

NAR Mol Med
Barry H, Scillia L, Gaubert A, Amrane S, Vialet B, Bégu D, Barthélémy P, Arpin C, Kauss T.   +8 more
europepmc   +1 more source