Results 261 to 270 of about 127,002 (321)

Topological Switch-OFF and β-Galactosidase-Triggered Switch-ON of Cyclic Antisense Oligonucleotides via CuAAC for Controlled RNA Cleavage. [PDF]

Bioconjug Chem
Miyaji K, Takeuchi K, Seio K.
europepmc   +1 more source

A Systematic Review and Model‐Based Meta‐Analysis of Pegylated‐Interferon‐α‐Induced HBsAg Loss in Chronic Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Pegylated‐interferon‐α (Peg‐IFNα) is a treatment option for chronic hepatitis B virus (HBV) infection. To quantify treatment response variability, we conducted a model‐based meta‐analysis (MBMA) of hepatitis B surface antigen (HBsAg) loss, defined as a binary outcome based on HBsAg levels falling below the limit of detection, with Peg‐IFNα ...
Nathan J. Hanan, Matthew L. Zierhut, Ahmed Nader, Anadi Mahajan, Amandeep Kaur, Krishna Kumar, Susan A. Dixon, Joyeta Das, Mindy Magee, Dickens Theodore, Vera Gielen   +10 more
wiley   +1 more source

Antisense oligonucleotides targeting the SARS-CoV-2 nucleocapsid gene decrease viral titers in hamsters. [PDF]

Mol Ther Nucleic Acids
Fitzpatrick C, Meunier N, Lepoder S, Dhorne-Pollet S, Da Costa B, Klonjkowki B, Eléouët JF, Burzio VA, Delmas B, Barrey E.   +9 more
europepmc   +1 more source

Anti sense and sensibility : renal and skin effects of (antisense) oligonucleotides

, 2017
Laurens van der Meer, van
openalex   +1 more source

Glycogen for Smyd3-antisense oligonucleotide delivery and enhanced liver cancer gene therapy

Ning Bai, Yi Huang, Jie Shen, Yingyin Peng, Huijie Zhang, Deqiang Hou   +5 more
openalex   +2 more sources

Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Hereditary angioedema (HAE) is a rare disorder linked to kallikrein‐kinin system dysregulation, which leads to uncontrolled activation of plasma prekallikrein. Donidalorsen is an antisense oligonucleotide designed to selectively degrade prekallikrein messenger RNA and thereby reduce prekallikrein production.
John K. Diep, Miao Liu, Pratap Singh, Steve Dorow, Danny M. Cohn, Laura Bordone, Kenneth B. Newman, Xiang Gao   +7 more
wiley   +1 more source

Evolution of antisense oligonucleotides: navigating nucleic acid chemistry and delivery challenges. [PDF]

Expert Opin Drug Discov
Ruchi R, Raman GM, Kumar V, Bahal R.
europepmc   +1 more source

MSC‐Derived Exosomal lnc‐AGT‐3: A Novel Anti‐Angiogenic Target in Age‐Related Macular Degeneration Through p53 Signaling Pathway

Aging Cell, Volume 25, Issue 2, February 2026.
MSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Lingjie Kong, Xiaoyan Han, Siyi Qi, Duo Li, Jingyue Zhang, Linyu Zhang, Shujie Zhang, Qin Jiang, Biao Yan, Chen Zhao   +9 more
wiley   +1 more source

Lipid Nanovesicles in Cancer Treatment: Improving Targeting and Stability of Antisense Oligonucleotides. [PDF]

Drug Des Devel Ther
Ding HY, Zhou H, Jiang Y, Chen SS, Wu XX, Li Y, Luo J, Zhang PF, Ding YN.   +8 more
europepmc   +1 more source