Results 261 to 270 of about 275,477 (365)

Skeletal muscle effects of antisense oligonucleotides targeting glycogen synthase 1 in a mouse model of Pompe disease. [PDF]

Clin Transl Med
Weiss L, Carrer M, Shmara A, Martin A, Yin H, Pal P, Cheng C, Ta L, Boock V, Fazeli Y, Chang M, Paguio M, Lee J, Yu H, Weiss J, Grossman TR, Raben N, Jafar-Nejad P, Kimonis V.   +18 more
europepmc   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Volume 64, Issue 27, July 1, 2025.
Biocatalysis has become a sustainable and cost‐competitive alternative to established chemical synthesis, enabling the enzyme‐based production of not only commodity chemicals but (non‐natural) amino acids, (rare) sugars, as well as synthetic nucleotides.
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe T. Bornscheuer   +4 more
wiley   +1 more source

Antisense oligonucleotides modulate aberrant inclusion of poison exons in SCN1A-related Dravet syndrome. [PDF]

JCI Insight
Tang S, Stamberger H, Calhoun JD, Weckhuysen S, Carvill GL.   +4 more
europepmc   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source

Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides. [PDF]

Sci Rep
Kusumoto K, Sasaki K, Uchida Y, Utsumi A, Yoshida T, Obika S, Inoue T, Okuhira K.   +7 more
europepmc   +1 more source

Small Nucleolar RNAs: Biological Functions and Diseases

MedComm, Volume 6, Issue 7, July 2025.
The majority of snoRNAs are derived from the intron region of genes, besides to intronic snoRNAs, some snoRNAs are transcribed as independent genes, often by Pol II or III, these snoRNAs are called intergenic snoRNAs. All of these play a role in the occurrence and progression of various diseases through multiple functions.
Yi Wang, Min Fu, Zaiyong Zheng, Jianguo Feng, Chunxiang Zhang   +4 more
wiley   +1 more source

APP antisense oligonucleotides are effective in rescuing mitochondrial phenotypes in human iPSC-derived trisomy 21 astrocytes. [PDF]

Alzheimers Dement
Thirumalai S, Livesey FJ, Patani R, Hung C.   +3 more
europepmc   +1 more source

Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Reham Hassan Mekky, Mohammed E. Abo‐El Fetoh, Safaa A. Faheem, Abdullah F. Radwan, Mariam H. Fawzy, Aya M. Mustafa, Mohamed A. Said, Daniela Calina, Javad Sharifi‐Rad, William C. Cho   +9 more
wiley   +1 more source

Suppression of Gal.ALPHA.1-3Gal expression by antisense oligonucleotides specific for porcine .ALPHA.-1,3-galactosyltransferase mRNA treatment.

, 1998
Akiko Taguchi, Masanobu Arita, Yasunori Kushi, Shizuo Handa   +3 more
openalex   +2 more sources

Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model. [PDF]

Int J Mol Sci
Akhter A, Md Sheikh A, Yoshino J, Kanda T, Nagai A, Matsuo M, Yano S.   +6 more
europepmc   +1 more source