Results 271 to 280 of about 275,477 (365)

Loss‐of‐function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2

Protein Science, Volume 34, Issue 7, July 2025.
Abstract The LRRK2 gene is a key contributor to the genetic risk of Parkinson's disease, and a priority drug target for the disorder. Leucine Rich Repeat Kinase 2, the protein product of LRRK2, is a multidomain enzyme implicated in a range of cellular processes—including endolysosomal trafficking and damage response. Based on the report that truncation
Sarah Butterfield, Susanne Herbst, Patrick Alfryn Lewis   +2 more
wiley   +1 more source

Antisense oligonucleotides in therapy for neurodegenerative disorders.

Advanced Drug Delivery Reviews, 2015
M. Evers, L. Toonen, W. V. van Roon-Mom
semanticscholar   +1 more source

Elevating microRNA levels by targeting biogenesis with steric-blocking antisense oligonucleotides. [PDF]

RNA
Havens MA, Hinrich AJ, Rigo F, Hastings ML.   +3 more
europepmc   +1 more source

Steroid‐Modulated Transcription Synergistically Forms DNA Double‐Strand Breaks With Topoisomerase II Inhibitor

Cancer Science, Volume 116, Issue 7, Page 1952-1962, July 2025.
Through our exploration of the synergistic effects of drug combinations for potential clinical applications, we found that steroids potentiate the anticancer effects of etoposide, a topoisomerase II inhibitor. Steroids, when combined with etoposide, increase DNA double‐strand breaks not via DNA repair inhibition but transcriptional modulation ...
Ying Zhao, Tetsuro Hisayoshi, Doudou Zhang, Saaya Suzuki, Takashi Watanabe, Atsuo Kobayashi, Qianqian Guo, Yukihide Momozawa, Takashi Shimokawa, Shunsuke Kato, Yoshio Miki, Shigeaki Sunada   +11 more
wiley   +1 more source

ANTISENSE OLIGONUCLEOTIDES AGAINST MCL-1 RESULT IN INCREASED APOPTOSIS OF HUMAN NEUTROPHILS

, 1999
Stephanie J. Leuenroth, P. S. Grutoski, Alfred Ayala, H. Hank Simms   +3 more
openalex   +1 more source

Therapeutic Antisense Oligonucleotides in Oncology: From Bench to Bedside. [PDF]

Cancers (Basel)
Çakan E, Lara OD, Szymanowska A, Bayraktar E, Chavez-Reyes A, Lopez-Berestein G, Amero P, Rodriguez-Aguayo C.   +7 more
europepmc   +1 more source

VHL‐Mediated SYT11 Degradation Suppresses Gastric Cancer Cell Growth and Invasion Through Downregulation of SPINK1

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT The ubiquitin‐proteasome system is a post‐translational modification pathway that plays a critical role in regulating cell survival and death. E3 ubiquitin ligases are key tumour regulators and potential therapeutic targets in gastric cancer.
Ji Su Yu, Mi‐Aie Hwang, Misun Won, Joo‐Young Im, Dae‐Hyuk Kweon, Yun Gyu Park, Bo‐Kyung Kim   +6 more
wiley   +1 more source

Sensitivity of splice sites to antisense oligonucleotides in vivo

, 1999
HALINA SIERAKOWSKA, MARIA J. SAMBADE, DANIEL SCHÜMPERLI, RYSZARD KOLE   +3 more
openalex   +2 more sources

Site-blocking antisense oligonucleotides as a mechanism to fine-tune MeCP2 expression. [PDF]

RNA
Vanderplow AM, Dodis GE, Rhee Y, Cikowski JJ, Gonzalez S, Smith ML, Gogliotti RG.   +6 more
europepmc   +1 more source

PTBP1 and Cancer: From RNA Regulation to Therapeutic Potential

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT Polypyrimidine tract binding protein 1 (PTBP1) belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and is a widely studied RNA‐binding protein involved in regulating mRNA splicing, stability, localization, and translation. In addition, PTBP1 can participate in various non‐coding RNA action processes and affect tumorigenesis ...
Chengdong Ji, Jing Zhu, Xiaochen Hou, Chen Zhou, Jiumei Zhao, Xiang Zheng, Yu Tang   +6 more
wiley   +1 more source