Results 271 to 280 of about 127,002 (321)

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

Clinical Applications of Antisense Oligonucleotides in Cancer: A Focus on Glioblastoma. [PDF]

Cells
Khuu A, Verreault M, Colin P, Tran H, Idbaih A.   +4 more
europepmc   +1 more source

The FsrA‐Mediated Iron‐Sparing Response Regulates the Biosynthesis of the Epipeptide EPE in Bacillus subtilis

Molecular Microbiology, Volume 125, Issue 2, Page 108-122, February 2026.
Under iron‐limited conditions, FsrA base‐pairs with the intergenic region between epeX and epeE, enhancing epeE translation and triggering EPE production. Toxin‐mediated cell lysis releases nutrients, including iron, which can be taken up by surviving cells.
Sarah Miercke, Rabea Ghandour, Kai Papenfort, Thorsten Mascher   +3 more
wiley   +1 more source

LncRNA DANCR Activates p38/mTOR‐Mediated Autophagy via ANXA2 to Exacerbate Oxygen‐Induced Retinal Neovascularization in Mice

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
This study reveals that the long non‐coding RNA DANCR drives pathological retinal neovascularization in oxygen‐induced retinopathy via an ANXA2‐dependent p38/MAPK/mTOR autophagy pathway. In hypoxic endothelial cells and a murine OIR model, DANCR promotes angiogenesis.
Yini Wang, Jiale Bai, Shihong Zhao
wiley   +1 more source

Determining off-target effects of splice-switching antisense oligonucleotides using short read RNAseq in neuronally differentiated human induced pluripotent stem cells. [PDF]

Hum Mol Genet
Kuijper EC, van der Graaf L, Pepers BA, Guimarães Ramos M, Korhorn S, Toonen LJA, Cats D, Buijsen RAM, Mina E, Mei H, van Roon-Mom WMC.   +10 more
europepmc   +1 more source

Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides. [PDF]

BMC Immunol
Begum S, Hossain MJ, Kim I, Min HS, Lim YN, Cho HJ, Ryu JH.   +6 more
europepmc   +1 more source

Antisense oligonucleotide-mediated exon skipping strategies as the treatment for rare diseases

, 2020
Dunhui Li
openalex   +1 more source

The expanding application of antisense oligonucleotides to neurodegenerative diseases. [PDF]

J Clin Invest
Sumner CJ, Miller TM.
europepmc   +1 more source

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides. [PDF]

Neurobiol Dis
Loreto A, Cramb KML, McDermott LA, Antoniou C, Cirilli I, Caiazza MC, Merlini E, Arthur-Farraj P, du Preez WD, Mock ED, Zhao HT, Bennett DL, Orsomando G, Coleman MP, Wade-Martins R.   +14 more
europepmc   +1 more source

Magnetic-Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models. [PDF]

Adv Sci (Weinh)
Ye X, Chen S, Xiong W, Wang F, Chan HF, Lai H, Guo X, Yang T, Shen S, Chen H, Wang W, Liu GS, Guo Y, Chen J.   +13 more
europepmc   +1 more source