Results 171 to 180 of about 2,242,574 (332)

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

Proceedings of the National Academy of Sciences of the United States of America, 1996
Jin Q. Cheng, Bruce A. Ruggeri, W. Klein, G. Sonoda, D. Altomare, D. Watson, J. Testa   +6 more
semanticscholar   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

A riboswitch-regulated antisense RNA in Listeria monocytogenes

Proceedings of the National Academy of Sciences of the United States of America, 2013
J. R. Mellin, Teresa Tiensuu, C. Bécavin, E. Gouin, J. Johansson, P. Cossart   +5 more
semanticscholar   +1 more source

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source

An unusual structure formed by antisense-target RNA binding involves an extended kissing complex with a four-way junction and a side-by-side helical alignment

, 2000
The antisense RNA CopA binds to the leader region of the repA mRNA (target: CopT). Previous studies on CopA-CopT pairing in vitro showed that the dominant product of antisense RNA-mRNA binding is not a full RNA duplex.
Kolb, F. A,, Westhof, E, Romby, P, Wagner, E.G.H, Ehresmann, C, Malmgren, C, Ehresmann, B   +6 more
core  

Antisense RNA controls the degradation of phycobilisomes in heterocyst-forming cyanobacteria by a transcriptional interference mechanism. [PDF]

Nucleic Acids Res
Álvarez-Escribano I, Brenes-Álvarez M, Georg J, Vioque A, Muro-Pastor AM.   +4 more
europepmc   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

miRNA-1175 downregulates a long non-coding natural antisense RNA and promotes long term memory. [PDF]

Sci Rep
Korneev SA, Taylor G, Wells OS, Naskar S, Korneeva EI, Kemenes I, Kemenes G.   +6 more
europepmc   +2 more sources

Biphasic Metabolic Control of Shikimic Acid Production in <i>E. coli</i> via an Antisense RNA. [PDF]

ACS Omega
Lerma-Escalera AI, Lerma-Escalera JA, Morones-Ramírez JR.   +2 more
europepmc   +1 more source

A targeted mutational strategy aiding in generating antisense RNA to knockdown the <i>Ehrlichia chaffeensis</i> P28-outer membrane protein 19 expression. [PDF]

J Bacteriol
Tong X, Ferm D, Liu H, Wang Y, Kondethimmanahalli C, Ganta RR.   +5 more
europepmc   +1 more source