Results 191 to 200 of about 2,242,574 (332)

Antisense RNA therapies for muscular dystrophies. [PDF]

J Neuromuscul Dis
Arechavala-Gomeza V, López-Martínez A, Aartsma-Rus A.   +2 more
europepmc   +1 more source

The genomic region of the 3' untranslated region (3'UTR) of PHO84, rather than the antisense RNA, promotes gene repression. [PDF]

Nucleic Acids Res, 2023
Hegazy YA, Cloutier SC, Utturkar SM, Das S, Tran EJ.   +4 more
europepmc   +1 more source

Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core

Chemistry – A European Journal, EarlyView.
RNA‐cleaving agents on a cubic octameric silsesquioxane core were synthesized and characterized. Several catalytic systems of these structures were screened using hexaribonucleotide models. The best systems were then further used to study their catalytic efficiency in cleaving a HER2 mRNA model sequence. The induced cleavage sites were also determined.
Hanni Haapsaari, Iris Tuomi, Pasi Virta
wiley   +1 more source

Exploring the Therapeutic Potential: Antisense RNA Delivery Via Bacteriophage Platform. [PDF]

Iran J Biotechnol
Jalali A, Komijani M, Alyafuri H, Rezaei M.   +3 more
europepmc   +1 more source

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Role of B1 antisense RNA on the proliferation and killing tumor ability of aged mouse spleen lymphocytes. [PDF]

Sci Rep
Wang X, Ali L, Wang W, Yang Y, Wu C, Zhang G, Feng X, Wang Y, Zhang H, Wang R, Zhang K, Lv Z, Wang X.   +12 more
europepmc   +1 more source

Hyperactive KIF5A in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT The highly polarised morphology of neurons and the sheer length of their axons make transport of cargoes throughout the cell a formidable task. Decades of evidence obtained from genetic studies on patients and animal models highlight deficits in axonal transport as a recurrent cause, or early contributing factor, in a plethora of ...
David Villarroel‐Campos, James N. Sleigh   +1 more
wiley   +1 more source

CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma. [PDF]

Cell Rep
Chadourne M, Griffith C, Jasani N, Xu X, Brennan E, Vera O, Mecozzi N, Wang K, Jaeger AM, Karreth FA.   +9 more
europepmc   +1 more source

A Co-Expressed Natural Antisense RNA FCER1A-AS Controls IgE-Dependent Immunity by Promoting Expression of FcεRIα. [PDF]

Microbiol Spectr, 2023
Tang RY, Yin L, Yao L, Zhang QF, Chen XP.   +4 more
europepmc   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source