Results 71 to 80 of about 61,173 (287)

Active antithrombin glycoforms are selectively physiosorbed on plasma extracellular vesicles

Journal of Extracellular Biology, 2022
Antithrombin (AT) is a glycoprotein produced by the liver and a principal antagonist of active clotting proteases. A deficit in AT function leads to AT qualitative deficiency, challenging to diagnose. Here we report that active AT may travel physiosorbed
Annalisa Radeghieri, Silvia Alacqua, Andrea Zendrini, Vanessa Previcini, Francesca Todaro, Giuliana Martini, Doris Ricotta, Paolo Bergese   +7 more
doaj   +1 more source

Pulmonary Thromboembolism in Immune Thrombocytopenia: A Report of Five Cases and a Review of the Literature

International Journal of General Medicine, 2021
Yong Tan,* Min Yan,* Zhen Cheng,* Xiangtao Pan Department of Haematology, The Taicang Hospital Affiliated of Soochow University, Taicang, 215400, Jiangsu, People’s Republic of China*These authors contributed equally to this ...
Tan Y, Yan M, Cheng Z, Pan X
doaj  

Antithrombin controls tumor migration, invasion and angiogenesis by inhibition of enteropeptidase

Scientific Reports, 2016
Antithrombin is a key inhibitor of the coagulation cascade, but it may also function as an anti-inflammatory, anti-angiogenic, anti-viral and anti-apoptotic protein.
Ginés Luengo-Gil, M. Calvo, Ester Martín-Villar, S. Águila, N. Bohdan, A. Antón, Salvador Espín, F. Ayala de la Peña, V. Vicente, J. Corral, M. Quintanilla, I. Martínez-Martínez   +11 more
semanticscholar   +1 more source

Classification of Platelet‐Activating Anti‐Platelet Factor 4 Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The prototypic anti‐platelet factor 4 (PF4) disorder—heparin‐induced thrombocytopenia and thrombosis (HITT)—features immunoglobulin G (IgG) class antibodies that activate platelets, monocytes, and neutrophils in a mainly heparin‐dependent fashion via Fcγ receptor‐dependent cellular activation.
Theodore E. Warkentin
wiley   +1 more source

A Retrospective Study of Adult and Pediatric D‐Dimer Tests to Identify Opportunities for Improved Utilization

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction D‐dimers are produced by lysis of cross‐linked fibrin. In children, D‐dimer testing is used to evaluate disseminated intravascular coagulation (DIC) and some inflammatory states, but its use is not validated for screening or ruling out suspected venous thromboembolic events (VTE).
Rabab Al Dawood, Hassan Abu Sabah, Natalie Mathews, James Douketis, Catherine Hayward   +4 more
wiley   +1 more source

Clinical management and outcomes for 51 Pugs reportedly diagnosed with protein‐losing enteropathy using VetCompass primary care veterinary data

Journal of Small Animal Practice, EarlyView.
Objectives To report the clinicopathological findings, treatment and outcomes of Pugs diagnosed with protein‐losing enteropathy using VetCompass primary care clinical data in the UK and to determine if referral or any specific treatments for protein‐losing enteropathy were associated with outcome. Materials and Methods Retrospective VetCompass study of
A. Kathrani, D. C. Brodbelt, D. B. Church, D. G. O’Neill   +3 more
wiley   +1 more source

Dried plasma retains hemostatic function and thermal stability during Arctic military operations

Transfusion, EarlyView.
Abstract Background Dried plasma offers a practical alternative for remote damage control resuscitation, providing hemostatic support and volume replacement. The Arctic presents challenges that necessitate the need for blood‐based resuscitation to extend the “golden hour.” To address this, we evaluated the hemostatic and thermal stability of dried ...
Kanwal Singh, Aron A. Shoara, Henry T. Peng, Viktor Prifti, Katy Moes, Cerys McGuinness, Tristan Bonnici, Maria Shiu, Sushmaa Chandralekha Selvakumar, Peter Andrisani, Pierre‐Marc Dion, Damien Miller, Sebastian Vuong, Colin A. Kretz, Philip J. Wallace, Shawn G. Rhind, Wendy Sullivan‐Kwantes, Andrew N. Beckett   +17 more
wiley   +1 more source

Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury

Kidney International, 2015
Antithrombin III, encoded by SerpinC1, is a major anti-coagulation molecule in vivo and has anti-inflammatory effects. We found that patients with low antithrombin III activities presented a higher risk of developing acute kidney injury after cardiac ...
Feng Wang, Guangyuan Zhang, Zeyuan Lu, A. Geurts, Kristie Usa, H. Jacob, A. Cowley, Niansong Wang, Mingyu Liang   +8 more
semanticscholar   +1 more source

Safety and efficacy of combined heparin/citrate anticoagulation for cell therapy collections in healthy adult allogeneic donors

Transfusion, EarlyView.
Abstract Background Reports on the safety and efficacy of combination heparin and citrate anticoagulation with cell therapy collections in adults are limited. There are no reports on the use of this combination in healthy allogeneic adult donors undergoing cell therapy collection. This retrospective analysis is the first study to examine its safety and
Jiahao Zhang, Minlin Wu, Sabrina Racine‐Brzostek, Sarah Shayo, Karina Yazdanbakhsh, Stephanie Dormesy, Patricia A. Shi   +6 more
wiley   +1 more source

Viscoelastic haemostatic assays in chronic liver disease—Profiling coagulation in the emergency department

Vox Sanguinis, EarlyView.
Abstract Background and Objectives The role of viscoelastic haemostatic assays (VHAs) versus conventional coagulation tests (CCTs) in chronic liver disease (CLD) in the emergency department (ED) is undefined. We aimed to characterize VHA profiles and concordance with CCT.
Akmez Latona, Kate Hill, Lara Roberts, Katherine Stuart, James Winearls, Biswadev Mitra   +5 more
wiley   +1 more source