Results 51 to 60 of about 22,631 (237)

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Plasma Antithrombin III Levels in Postoperative Patients

, 2019
Aim: To determine preoperative and postoperative plasma concentration of antithrombin III in three different disciplines of surgery as well as to carry out an inter-comparison of antithrombin III levels after major surgical procedures in orthopedic ...
Syed Nadeeem Mansoor, syed moiz nadeem
core   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

RNA‐DNA Fusomer Fibers With Customizable Physicochemical, Mechanical, and Biological Properties for Next‐Generation Therapeutics

Small, EarlyView.
ABSTRACT We introduce RNA‐DNA fusomers, a new class of chemically synthesized oligonucleotides that combine the versatile properties of RNA and DNA within a single sequence and self‐assemble into higher‐order functional structures via a simple one‐pot annealing reaction.
Yasmine Radwan, Laura P. Rebolledo, Yelixza I. Avila, Elizabeth Skelly, Lauren Rackley, Julio Navas Hernandez, Renata de Freitas Saito, Laxmi K. Pandey, Hemani Chhabra, Alexander J. Lushnikov, Tatiane Katsue Furuya, Ana Luiza Lomba, Da Shi, Edward Cedrone, Ian Marriott, Morgan R. Chandler, Meni Wanunu, Aleksei Aksimentiev, Alexey V. Krasnoslobodtsev, Roger Chammas, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Comparison of Protective Effects of Recombinant Antithrombin Gamma and Plasma-Derived Antithrombin on Sepsis-Induced Disseminated Intravascular Coagulation and Multiple Organ Failure

Clinical and Applied Thrombosis/Hemostasis, 2020
In Japan, the dose of the new recombinant antithrombin III concentrate (rAT-gamma) is titrated according to patient body weight (BW), while conventional plasma-derived antithrombin concentrates (AT) are administered as a fixed dose.
Hiromitsu Kuroda MD, Yoshiki Masuda MD, PhD   +1 more
doaj   +1 more source

Antithrombin III associated with fibrinogen predicts the risk of cerebral ischemic stroke

, 2011
Background and purpose: \ud \ud The purpose of this study is to examine the feasibility of developing plasma predictive value biomarkers of cerebral ischemic stroke before imaging evidence is acquired. \ud \ud Methods: \ud \ud Blood samples were obtained
Xunming Ji, Meng, Ran, Ji, Xunming, Meng, S., Wang, Xiaoying, Sui Meng, Meng, R., Yuchuan Ding, Li, Zhi-Yong, Zhi-Yong Li, Ji, X., Ran Meng, Xiaoying Wang, Li, Z. Y., Ding, Y., Ding, Yuchuan, Wang, X., Meng, Sui   +17 more
core   +1 more source

Influence of patient factors on target plasma volume treated attainment rate during double filtration plasmapheresis in patients with hypertriglyceridemic acute pancreatitis

Therapeutic Apheresis and Dialysis, EarlyView.
Abstract Introduction This study aims to investigate patient factors affecting the rate of plasma volume target attained in hypertriglyceridemic pancreatitis (HTG‐AP) patients undergoing double filtration plasmapheresis (DFPP). Methods A retrospective analysis of 82 HTG‐AP‐interpreted patients from January 2019 to April 2024 compared target plasma ...
Hui Zhang, Chenqiang Zhu, Yunlong Wu
wiley   +1 more source

Priming of labor with tafoxiparin in nulliparous term pregnant women with unripe cervix—Proof‐of‐concept and dose‐finding results from a randomized controlled trial

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This study shows that tafoxiparin 300 mg can increase the rate of cervical ripening and the likelihood of spontaneous onset of labor, while also reducing the duration of labor in women achieving spontaneous onset of labor. The favorable safety profile of tafoxiparin suggests suitability for routine clinical use, including home administration.
Gunvor Ekman‐Ordeberg, Maria Jonsson, Marie Blomberg, Malin Melin, Ylva Stjernholm‐Vladic, Sebastian B. Gidlöf, Dag Wide‐Swensson, Kati Tihtonen, Inge C. Olsen, Lena Degling‐Wikingsson, Per Blom, Leena Rahkonen   +11 more
wiley   +1 more source

Correction of Antithrombin III Deficiency in Disseminated Intravascular Coagulation

Общая реаниматология, 2008
Although antithrombin (AT) III concentrate therapy is attended by an increased risk of hemorrhage, the data available in the literature suggest that the agent may have a positive effect on outcome in disseminated intravascular coagulation (DIC ...
Ye. L. Neporada, N. A. Vorobyeva, E. V. Nedashkovsky   +2 more
doaj   +1 more source

Controlled trial of antithrombin III supplementation in fulminant hepatic failure

, 1993
Patients with fulminant hepatic failure have severe circulatory disturbances which may be due to fibrin and cellular plugs in micro-vessels which are a consequence of intravascular coagulation and which can lead to multiorgan failure.
Williams, Roger, Langley, Peter G., Keays, Rick, Hughes, Robin D., Forbes, Alastair   +4 more
core   +1 more source