Results 61 to 70 of about 3,507,689 (226)

Prospective Study of Targeted Busulfan–Fludarabine Conditioning for Hematopoietic Stem Cell Transplantation in Genetic Rare Diseases

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Genetic rare diseases (GRDs), including chronic granulomatous disease, familial hemophagocytic lymphohistiocytosis, and congenital neutropenia, often require hematopoietic stem cell transplantation (HSCT) as the only curative option.
Bo Kyung Kim, Kyung Taek Hong, Jung Yoon Choi, Hyun Jin Park, Kyung‐Sang Yu, In‐Jin Jang, Hyoung Jin Kang   +6 more
wiley   +1 more source

Antithrombin III associated with fibrinogen predicts the risk of cerebral ischemic stroke

, 2011
Background and purpose: \ud \ud The purpose of this study is to examine the feasibility of developing plasma predictive value biomarkers of cerebral ischemic stroke before imaging evidence is acquired. \ud \ud Methods: \ud \ud Blood samples were obtained
Xunming Ji, Meng, Ran, Ji, Xunming, Meng, S., Wang, Xiaoying, Sui Meng, Meng, R., Yuchuan Ding, Li, Zhi-Yong, Zhi-Yong Li, Ji, X., Ran Meng, Xiaoying Wang, Li, Z. Y., Ding, Y., Ding, Yuchuan, Wang, X., Meng, Sui   +17 more
core   +1 more source

Antithrombin III concentrate to treat heparin resistance in patients undergoing cardiac surgery [PDF]

, 2002
Objective: The purpose of this report is to describe the clinical use of antithrombin III concentrate in 53 patients who were found, in the operating room before cardiopulmonary bypass, to be heparin resistant.
Despotis, George J., Lemmer, John H.
core   +1 more source

Thrombotic Microangiopathy‐Like Phenotype in Patients With Infection‐Associated Disseminated Intravascular Coagulation Treated With Thrombomodulin Alfa

European Journal of Haematology, EarlyView.
ABSTRACT Despite disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) sharing features of thrombocytopenia, organ dysfunction, and bleeding, the relationship between these two conditions remains unclear. We therefore conducted a post hoc analysis of post‐marketing surveillance data from Japan to evaluate the clinical ...
Naoki Takezako, Fumiyo Komatsu, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Kazuo Kawasugi, Seiji Madoiwa, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Kohji Okamoto, Hideo Wada   +11 more
wiley   +1 more source

Controlled trial of antithrombin III supplementation in fulminant hepatic failure

, 1993
Patients with fulminant hepatic failure have severe circulatory disturbances which may be due to fibrin and cellular plugs in micro-vessels which are a consequence of intravascular coagulation and which can lead to multiorgan failure.
Williams, Roger, Langley, Peter G., Keays, Rick, Hughes, Robin D., Forbes, Alastair   +4 more
core   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Pulmonary arterial thrombosis in a neonate with homozygous deficiency of antithrombin III: successful outcome following pulmonary thrombectomy and infusions of antithrombin III concentrate

, 2000
We report a newborn male who presented with severe central cyanosis on the third day of life. Partial thrombotic obstruction of the pulmonary trunk secondary to Antithrombin III (homozygous defect of heparin binding site) deficiency was subsequently ...
Rosenthal, E, Roman, K, Razavi, R; id_orcid   +2 more
core   +5 more sources

Correction of Antithrombin III Deficiency in Disseminated Intravascular Coagulation

Общая реаниматология, 2008
Although antithrombin (AT) III concentrate therapy is attended by an increased risk of hemorrhage, the data available in the literature suggest that the agent may have a positive effect on outcome in disseminated intravascular coagulation (DIC ...
Ye. L. Neporada, N. A. Vorobyeva, E. V. Nedashkovsky   +2 more
doaj   +1 more source

Patient Preferences for the Treatment of Haemophilia A and B in France

Haemophilia, EarlyView.
ABSTRACT Introduction Haemophilia impacts health and quality of life. Advances in treatments such as factor replacement therapy (FRT), bispecific monoclonal antibody (BS‐mAb), gene therapy (GT), rebalancing treatment and high sustained factor necessitate understanding patient preferences to inform therapeutic strategies. Aim This study quantified trade‐
Yesim Dargaud, Yasmine Fahfouhi, Monia Ezzalfani, Astrid Foix Colonier, Alaeddine Sidhom, Aline Gauthier, Jérémie Rudant, Meriem Kessouri, Nicolas Giraud, Benoît Guillet, Anaïs Reynaud   +10 more
wiley   +1 more source

Disorders Of the Hemostatic System as A Predictor of Adverse Outcome In COVID-19

Архивъ внутренней медицины
COVID-19 is associated with a high risk of thrombotic complications, which determine the severity and outcome of the disease. Identifying key predictors of adverse outcomes among hemostatic system parameters remains an important task. Aime. To assess the
L. A. Anisko, I. A. Karpov
doaj   +1 more source