Results 81 to 90 of about 37,867 (235)

Levels of Natural Anticoagulants Protein C, Protein S and Antithrombin III in Patients with Solid Malignancies

Journal of Rawalpindi Medical College, 2014
Background: To estimate plasma levels of natural anticoagulants, i.e., Protein C, Protein S and Antithrombin III in patients with solid malignancies Methods: A cross-sectional study was conducted wherein plasma levels of Protein C,S and Antithrombin III (
Samina T.Amanat
doaj   +2 more sources

Stroke From Paradoxical Embolism in a Young Patient With Sickle‐Cell Disease and High Fetal Hemoglobin: A Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Acute infarcts and microvascular ischemic changes in the brain of a young patient with Sickle‐Cell Disease despite High Fetal Hemoglobin. ABSTRACT Sickle‐cell disease (SCD) is characterized by abnormal hemoglobin (Hb) polymerization, leading to erythrocyte sickling and microvascular obstruction.
Yi Hui Luo, Navid Zuberi, Angelo Rizzolo, Margaret Warner, Stephane Isnard, Jean‐Pierre Routy   +5 more
wiley   +1 more source

Fitusiran treatment modulates the ratio between alpha‐ and beta‐antithrombin isoforms

HemaSphere, Volume 10, Issue 5, May 2026.
Abstract Antithrombin (AT) circulates as two distinct isoforms, alpha‐ and beta‐AT, which differ in their glycosylation profiles; alpha‐AT is fully glycosylated at positions Asn128, Asn167, Asn187, and Asn224, whereas beta‐AT lacks Asn167 glycosylation.
Geneviève McCluskey, Hortense Maynadié, Delphine Borgel, Laurent Frenzel, Annie Harroche, Elsa Bianchini, Stephanie Roullet, Olivier D. Christophe, Cecile V. Denis, Caterina Casari, Peter J. Lenting   +10 more
wiley   +1 more source

Oesophagogastrostomy Using Double‐Flap Technique Following Resection of an Extensive Leiomyosarcoma in a Cat

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
A cat with an extensive esophagogastric leiomyosarcoma underwent distal esophagectomy and proximal gastrectomy, followed by esophagogastrostomy using the double‐flap technique (DFT). Reconstruction with DFT was feasible and postoperative complications including leakage, stricture, and reflux were not observed; oral feeding resumed on postoperative day (
Takeshi Hayakawa, Kumiko Ishigaki, Toshihiro Watari, Kazushi Asano   +3 more
wiley   +1 more source

Bleeding Disorders in Children With Genetic Diseases: A Narrative Review

Acta Paediatrica, Volume 115, Issue 5, Page 1015-1024, May 2026.
ABSTRACT Aim The lack of data on bleeding risk assessment in children with genetic diseases is concerning given their increased care needs and risk of haemorrhagic complications compared to the general population. Identification of haemostatic disorders is crucial for implementing preventive measures and mitigating bleeding risk.
Raphaelle Cagol, Mariam Sbeity Barakat, Marjolaine Willems, Tasnime Akbaraly, Biron‐Andreani Christine, Isabelle Diaz, Alexandre Theron   +6 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan, Vishnu Sharma, Venkatesh Atul Bhattaram, Xiaolei Pan, Justin Earp, Yun Wang, Jiang Liu, Hao Zhu   +7 more
wiley   +1 more source

Hypercoagulability risk factors associated with venous thromboembolic events in patients with idiopathic membranous nephropathy and nephrotic syndrome: a prospective observational study

Romanian Journal of Laboratory Medicine, 2013
Introducere: Sindromul nefrotic (SN) este asociat cu o incidenţă crescută a complicaţiilor tromboembolice datorită multiplelor anomalii ale sistemul coagulării şi al hemostazei întâlnite la aceşti pacienţi.
Gener Ismail, Harza Mihai, Tuta Liliana, Jurubita Roxana, Motoi Otilia, Ditoiu Alecse Valerian   +5 more
doaj   +1 more source

Houston, we have a problem: Coagulation concerns during long‐term spaceflight

Experimental Physiology, EarlyView.
Lewis Fall, Damian M. Bailey
wiley   +1 more source

Peptide Angio‐3 Attenuates Pulmonary Fibrosis Via Modulation of the Coagulation Factor Xa—Protease‐Activated Receptor‐1 Signaling Axis

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Schematic illustrating the mechanism by which the peptide Angio‐3 attenuates pulmonary fibrosis. Following lung injury, activation of the coagulation cascade via Factor Xa (FXa) signals through protease‐activated receptor‐1 (PAR‐1) to activate fibroblasts and promote fibrosis.
Dan Wang, Fei Li, Hui Chen, Bochuan Deng, Lu Cheng, Jiawen Ma, Rong Li, Lang Qu, Junqiu Xie, Ya Zhao   +9 more
wiley   +1 more source