Results 1 to 10 of about 59,908 (306)
Modeling sRNA-Regulated Plasmid Maintenance. [PDF]
PLoS ONE, 2017 We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
doaj +4 more sources
Foodborne botulism from consumption of homemade spoiled eggs: a case series and literature review [PDF]
Frontiers in MedicineBotulism is a rare but life-threatening condition that primarily results from ingestion of food contaminated with the exotoxins produced by Clostridium botulinum.
Suyu Wei, Liang Sun
doaj +2 more sources
A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A [PDF]
Toxins, 2018 The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and makes it a less-than-optimal therapeutic.
Jianlong Lou +14 more
doaj +4 more sources
Mono- and multidomain defense toxins of the RelE/ParE superfamily [PDF]
mBioToxin–antitoxin (TA) modules are widely distributed across prokaryotes, often existing in large numbers despite their associated fitness costs. Most type II TA modules are bicistronic operons encoding a monodomain toxin and its cognate protein antitoxin.
Kenn Gerdes
doaj +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Toxin–antitoxin systems are enigmatic components of microbial genomes, with their biological functions being a conundrum of debate for decades. Increasingly, TAs are being found to have a role in defense against bacteriophages.
K. Ernits +21 more
semanticscholar +1 more source
Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems
Nature, 2022 Retrons are prokaryotic genetic retroelements encoding a reverse transcriptase that produces multi-copy single-stranded DNA1 (msDNA). Despite decades of research on the biosynthesis of msDNA2, the function and physiological roles of retrons have remained
Jacob Bobonis +19 more
semanticscholar +1 more source
Investigation of the Frequency of Foodborne Botulism in Patients Referred to Loghman Hospital in Tehran City, Iran, From 2008 to 2019 [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Foodborne botulism is a fatal paralytic illness caused mainly by the neurotoxin produced by an anaerobic bacterium called Clostridium botulinum. In this study, the frequency of foodborne botulism in patients referred to a hospital in Iran has
Mohammad Mehdi Soltan Dallal +7 more
doaj +1 more source
Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin
mBio, 2023 Biofilms allow microbes to resist a multitude of stresses and stay proximate to vital nutrients. The mechanisms of entering and leaving a biofilm are highly regulated to ensure microbial survival, but are not yet well described in archaea.
April M. Lewis +5 more
semanticscholar +1 more source