Results 1 to 10 of about 54,312 (308)
Modeling sRNA-Regulated Plasmid Maintenance. [PDF]
PLoS ONE, 2017 We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
doaj +5 more sources
A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A [PDF]
Toxins, 2018 The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and makes it a less-than-optimal therapeutic.
Jianlong Lou +14 more
doaj +7 more sources
MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding [PDF]
Nature Communications, 2023 Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M.
Xibing Xu +9 more
doaj +4 more sources
mBio, 2019 Toxin-antitoxin (TA) systems are broadly distributed modules whose biological roles remain mostly unknown. The mqsRA system is a noncanonical TA system in which the toxin and antitoxins genes are organized in operon but with the particularity that the ...
Nathan Fraikin +3 more
doaj +2 more sources
Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin
mBio, 2023 Biofilms allow microbes to resist a multitude of stresses and stay proximate to vital nutrients. The mechanisms of entering and leaving a biofilm are highly regulated to ensure microbial survival, but are not yet well described in archaea.
April M. Lewis +5 more
semanticscholar +1 more source
Investigation of the Frequency of Foodborne Botulism in Patients Referred to Loghman Hospital in Tehran City, Iran, From 2008 to 2019 [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Foodborne botulism is a fatal paralytic illness caused mainly by the neurotoxin produced by an anaerobic bacterium called Clostridium botulinum. In this study, the frequency of foodborne botulism in patients referred to a hospital in Iran has
Mohammad Mehdi Soltan Dallal +7 more
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A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Toxin–antitoxin systems are enigmatic and diverse elements of bacterial and bacteriophage genomes. We have uncovered remarkable versatility in an antitoxin protein domain that has evolved to neutralize dozens of different toxin domains.
T. Kurata +15 more
semanticscholar +1 more source
Biological Functions of Type II Toxin-Antitoxin Systems in Bacteria
Microorganisms, 2021 After the first discovery in the 1980s in F-plasmids as a plasmid maintenance system, a myriad of toxin-antitoxin (TA) systems has been identified in bacterial chromosomes and mobile genetic elements (MGEs), including plasmids and bacteriophages.
M. Kamruzzaman, Alma Y. Wu, J. Iredell
semanticscholar +1 more source