Results 1 to 10 of about 42,746 (184)

Modeling sRNA-Regulated Plasmid Maintenance. [PDF]

PLoS ONE, 2017
We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
doaj   +4 more sources

A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A [PDF]

Toxins, 2018
The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and makes it a less-than-optimal therapeutic.
Jianlong Lou, Weihua Wen, Fraser Conrad, Qi Meng, Jianbo Dong, Zhengda Sun, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, Luisa W. Cheng, Thomas D. Henderson, Jennifer L. Brown, Theresa J. Smith, Leonard A. Smith, Anthony Cormier, James D. Marks   +14 more
doaj   +4 more sources

Foodborne botulism from consumption of homemade spoiled eggs: a case series and literature review [PDF]

Frontiers in Medicine
Botulism is a rare but life-threatening condition that primarily results from ingestion of food contaminated with the exotoxins produced by Clostridium botulinum.
Suyu Wei, Liang Sun
doaj   +2 more sources

Establishment of a Novel Oral Murine Model of Ricin Intoxication and Efficacy Assessment of Ovine Ricin Antitoxins

Toxins, 2020
Ricin, produced from the castor beans of Ricinus communis, is a cytotoxin that exerts its action by inactivating ribosomes and causing cell death. Accidental (e.g., ingestion of castor beans) and/or intentional (e.g., suicide) exposure to ricin through ...
Sarah J. Whitfield, Debbie B. Padgen, Simon Knight, Robert J. Gwyther, Jane L. Holley, Graeme C. Clark, A. Christopher Green   +6 more
doaj   +1 more source

Post-Exposure Anti-Ricin Treatment Protects Swine against Lethal Systemic and Pulmonary Exposures

Toxins, 2020
Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor bean plant), is one of the most lethal toxins known. To date, there is no approved post-exposure therapy for ricin exposures.
Reut Falach, Anita Sapoznikov, Yentl Evgy, Moshe Aftalion, Arik Makovitzki, Avi Agami, Avishai Mimran, Elad Lerer, Alon Ben David, Ran Zichel, Shahaf Katalan, Amir Rosner, Tamar Sabo, Chanoch Kronman, Yoav Gal   +14 more
doaj   +1 more source

An Auto-Regulating Type II Toxin-Antitoxin System Modulates Drug Resistance and Virulence in Streptococcus suis

Frontiers in Microbiology, 2021
Toxin-antitoxin (TA) systems are ubiquitous genetic elements that play an essential role in multidrug tolerance and virulence of bacteria. So far, little is known about the TA systems in Streptococcus suis.
Qibing Gu, Qibing Gu, Qibing Gu, Peijuan He, Peijuan He, Peijuan He, Dan Wang, Dan Wang, Dan Wang, Jiale Ma, Jiale Ma, Jiale Ma, Xiaojun Zhong, Xiaojun Zhong, Xiaojun Zhong, Xiaojun Zhong, Yinchu Zhu, Yinchu Zhu, Yinchu Zhu, Yinchu Zhu, Yue Zhang, Yue Zhang, Yue Zhang, Yue Zhang, Qiankun Bai, Qiankun Bai, Qiankun Bai, Zihao Pan, Zihao Pan, Zihao Pan, Huochun Yao, Huochun Yao, Huochun Yao   +32 more
doaj   +1 more source

Purification and characterization of alkaline soda-bleach stable protease from Bacillus sp. APP-07 isolated from Laundromat soil

Journal of Genetic Engineering and Biotechnology, 2018
The detergent-compatible alkaline protease was produced from the bacterial strain Bacillus sp. APP-07 isolated from Laundromat soil of Solapur, Maharashtra, India.
I.K. Shaikh, P.P. Dixit, T.M. Shaikh
doaj   +1 more source

Toxin-Antitoxin Gene Pairs Found in Tn3 Family Transposons Appear To Be an Integral Part of the Transposition Module

mBio, 2020
Much of the diversity of prokaryotic genomes is contributed by the tightly controlled recombination activity of transposons (Tns). The Tn3 family is arguably one of the most widespread transposon families.
Gipsi Lima-Mendez, Danillo Oliveira Alvarenga, Karen Ross, Bernard Hallet, Laurence Van Melderen, Alessandro M. Varani, Michael Chandler   +6 more
doaj   +1 more source

Unrelated toxin-antitoxin systems cooperate to induce persistence. [PDF]

, 2015
Persisters are drug-tolerant bacteria that account for the majority of bacterial infections. They are not mutants, rather, they are slow-growing cells in an otherwise normally growing population.
Fasani, Rick A, Savageau, Michael A
core   +1 more source

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]

, 2012
Bacterial genomes commonly contain ‘addiction’ gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Brown, Sam P., Heinemann, Jack A., Rankin, Daniel J., Turner, Leighton A.   +3 more
core   +1 more source