Results 11 to 20 of about 59,908 (306)

A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Toxin–antitoxin systems are enigmatic and diverse elements of bacterial and bacteriophage genomes. We have uncovered remarkable versatility in an antitoxin protein domain that has evolved to neutralize dozens of different toxin domains.
T. Kurata, C. Saha, J. Buttress, Toomas Mets, T. Brodiazhenko, K. Turnbull, Ololade F. Awoyomi, S. A. Oliveira, Steffi Jimmy, K. Ernits, Maxence Delannoy, Karina Persson, T. Tenson, H. Strahl, V. Hauryliuk, G. Atkinson   +15 more
semanticscholar   +1 more source

Post-Exposure Anti-Ricin Treatment Protects Swine against Lethal Systemic and Pulmonary Exposures

Toxins, 2020
Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor bean plant), is one of the most lethal toxins known. To date, there is no approved post-exposure therapy for ricin exposures.
Reut Falach, Anita Sapoznikov, Yentl Evgy, Moshe Aftalion, Arik Makovitzki, Avi Agami, Avishai Mimran, Elad Lerer, Alon Ben David, Ran Zichel, Shahaf Katalan, Amir Rosner, Tamar Sabo, Chanoch Kronman, Yoav Gal   +14 more
doaj   +1 more source

Biological Functions of Type II Toxin-Antitoxin Systems in Bacteria

Microorganisms, 2021
After the first discovery in the 1980s in F-plasmids as a plasmid maintenance system, a myriad of toxin-antitoxin (TA) systems has been identified in bacterial chromosomes and mobile genetic elements (MGEs), including plasmids and bacteriophages.
M. Kamruzzaman, Alma Y. Wu, J. Iredell
semanticscholar   +1 more source

Establishment of a Novel Oral Murine Model of Ricin Intoxication and Efficacy Assessment of Ovine Ricin Antitoxins

Toxins, 2020
Ricin, produced from the castor beans of Ricinus communis, is a cytotoxin that exerts its action by inactivating ribosomes and causing cell death. Accidental (e.g., ingestion of castor beans) and/or intentional (e.g., suicide) exposure to ricin through ...
Sarah J. Whitfield, Debbie B. Padgen, Simon Knight, Robert J. Gwyther, Jane L. Holley, Graeme C. Clark, A. Christopher Green   +6 more
doaj   +1 more source

tRNAfMet Inactivating Mycobacterium tuberculosis VapBC Toxin-Antitoxin Systems as Therapeutic Targets

Antimicrobial Agents and Chemotherapy, 2022
The Mycobacterium tuberculosis genome contains an abundance of toxin-antitoxin (TA) systems, 50 of which belong to the VapBC family. The activity of VapC toxins is controlled by dynamic association with their cognate antitoxins—the toxin is inactive when
Unnati Chauhan, Valdir C. Barth, N. Woychik   +2 more
semanticscholar   +1 more source

Medical Countermeasures against Ricin Intoxication

Toxins, 2023
Ricin toxin is a disulfide-linked glycoprotein (AB toxin) comprising one enzymatic A chain (RTA) and one cell-binding B chain (RTB) contained in the castor bean, a Ricinus species.
Christine Rasetti-Escargueil, Arnaud Avril   +1 more
doaj   +1 more source

Type II Toxin-Antitoxin Systems: Evolution and Revolutions

Journal of Bacteriology, 2020
Type II toxin-antitoxin (TA) systems are small genetic elements composed of a toxic protein and its cognate antitoxin protein, the latter counteracting the toxicity of the former.
N. Fraikin, F. Goormaghtigh, L. Van Melderen   +2 more
semanticscholar   +1 more source

Identification, functional characterization, assembly and structure of ToxIN type III toxin–antitoxin complex from E. coli

Nucleic Acids Research, 2022
Toxin–antitoxin (TA) systems are proposed to play crucial roles in bacterial growth under stress conditions such as phage infection. The type III TA systems consist of a protein toxin whose activity is inhibited by a noncoding RNA antitoxin. The toxin is
Parthasarathy Manikandan, S. Sandhya, Kavya Nadig, Souradip Paul, N. Srinivasan, U. Rothweiler, Mahavir Singh   +6 more
semanticscholar   +1 more source

Purification and characterization of alkaline soda-bleach stable protease from Bacillus sp. APP-07 isolated from Laundromat soil

Journal of Genetic Engineering and Biotechnology, 2018
The detergent-compatible alkaline protease was produced from the bacterial strain Bacillus sp. APP-07 isolated from Laundromat soil of Solapur, Maharashtra, India.
I.K. Shaikh, P.P. Dixit, T.M. Shaikh
doaj   +1 more source

Unrelated toxin-antitoxin systems cooperate to induce persistence. [PDF]

, 2015
Persisters are drug-tolerant bacteria that account for the majority of bacterial infections. They are not mutants, rather, they are slow-growing cells in an otherwise normally growing population.
Fasani, Rick A, Savageau, Michael A
core   +1 more source