Results 51 to 60 of about 42,772 (209)

A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection [PDF]

, 2016
Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia.
Beamer, Gillian, Curiel, David T, Debatis, Michele, Dmitriev, Igor P, Kashentseva, Elena A, Kim, Hyeun Bum, Schmidt, Diane J, Shoemaker, Charles B, Steele, Jennifer A, Sun, Xingmin, Tremblay, Jacqueline M, Tzipori, Saul, Wang, Yaunkai   +12 more
core   +2 more sources

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

Paeoniflorin Derivative in Paeoniae Radix Aqueous Extract Suppresses Alpha-Toxin of Staphylococcus aureus

Frontiers in Microbiology, 2021
The emergence and dissemination of bacterial infections is paralyzing our public health systems worldwide. Worse still, there are no effective antibiotics against bacterial toxins, which facilitate the infection.
Xiaoye Liu, Xiaoye Liu, Xiaoye Liu, Yafei Zhang, Zengshun Li, Pengpeng Zhang, Ying-Jian Sun, Yi-Jun Wu   +7 more
doaj   +1 more source

Identification and characterisation of toxin-antitoxin systems (TA) in Burkholderia pseudomallei [PDF]

, 2013
The aim of this study was to identify and characterise type II toxin-antitoxin (TA) systems in Burkholderia pseudomallei, the causative agent of the human disease melioidosis. 8 putative TA systems were identified within the genome of B. pseudomallei
Butt, Aaron Trevor
core  

Molecular Characterization of Protease Activity in Serratia sp. Strain SCBI and Its Importance in Cytotoxicity and Virulence [PDF]

, 2014
A newly recognized Serratia species, termed South African Caenorhabditis briggsae isolate (SCBI), is both a mutualist of the nematode Caenorhabditis briggsae KT0001 and a pathogen of lepidopteran insects. Serratia sp.
Petersen, Lauren M., Tisa, Louis S.
core   +2 more sources

Inhibition of Targeted Bacterial Growth Using MazF‐Expressing Phagemids: A Novel Therapeutic Approach Based on Endoribonuclease Toxin Molecules

Microbiology and Immunology, EarlyView.
ABSTRACT The extensive and indiscriminate use of antibiotics, which are intended to halt bacterial growth or eliminate them, has unintentionally given rise to antimicrobial resistance (AMR), which is a critical threat to global health. In the pursuit of alternative solutions, researchers have focused on type II toxin–antitoxin systems prevalent within ...
Hana Hasegawa, Tatsuki Miyamoto, Rino Isshiki, Tomoyoshi Kaneko, Kenichi Takasugi, Naohiro Noda, Satoshi Tsuneda   +6 more
wiley   +1 more source

Generation of Highly Efficient Equine-Derived Antibodies for Post-Exposure Treatment of Ricin Intoxications by Vaccination with Monomerized Ricin

Toxins, 2018
Ricin, a highly lethal toxin derived from the seeds of Ricinus communis (castor beans) is considered a potential biological threat agent due to its high availability, ease of production, and to the lack of any approved medical countermeasure against ...
Reut Falach, Anita Sapoznikov, Ron Alcalay, Moshe Aftalion, Sharon Ehrlich, Arik Makovitzki, Avi Agami, Avishai Mimran, Amir Rosner, Tamar Sabo, Chanoch Kronman, Yoav Gal   +11 more
doaj   +1 more source

A Rabbit Model for the Evaluation of Drugs for Treating the Chronic Phase of Botulism

Toxins, 2021
Antitoxin, the only licensed drug therapy for botulism, neutralizes circulating botulinum neurotoxin (BoNT). However, antitoxin is no longer effective when a critical amount of BoNT has already entered its target nerve cells.
Amram Torgeman, Eran Diamant, Eyal Dor, Arieh Schwartz, Tzadok Baruchi, Alon Ben David, Ran Zichel   +6 more
doaj   +1 more source

Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]

, 1990
The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Ahnert-Hilger, G., Dayanithi, G., Gratzl, Manfred, Nordmann, J. J., Weller, U.   +4 more
core   +1 more source

Overexpression of Escherichia coli yaiX Confers Multidrug Resistance and Enhances Virulence in the Silkworm Infection Model

Microbiology and Immunology, EarlyView.
ABSTRACT The emergence of bacteria with both antimicrobial resistance and high virulence has become a global health concern, underscoring the urgent need to elucidate the molecular basis underlying these traits. Here, we employed the silkworm (Bombyx mori) infection model, which is suitable for high‐throughput screening, together with an Escherichia ...
Kinuka Hongu, Kazuya Ishikawa, Tomoki Kosaki, Shin‐Ichi Miyoshi, Kazuyuki Furuta, Chikara Kaito   +5 more
wiley   +1 more source