Results 81 to 90 of about 46,189 (213)

Exploring preharvest sprouting (PHS) and late‐maturity alpha‐amylase (LMA) in wheat through proteomics: A review

Crop Science, Volume 65, Issue 3, May/June 2025.
Abstract Climate fluctuations have made it increasingly difficult for growers to maintain the quality and quantity of their grain to a degree that is satisfactory to buyers. Challenges for growers are preharvest sprouting (PHS) and late‐maturity alpha‐amylase (LMA), which are influenced by weather and genetic differences between varieties. Both lead to
John H. Kelly, Alison L. Thompson, Amber L. Hauvermale   +2 more
wiley   +1 more source

Mechanisms for Differential Protein Production in Toxin–Antitoxin Systems

Toxins, 2017
Toxin–antitoxin (TA) systems are key regulators of bacterial persistence, a multidrug-tolerant state found in bacterial species that is a major contributing factor to the growing human health crisis of antibiotic resistance. Type II TA systems consist of
Heather S. Deter, Roderick V. Jensen, William H. Mather, Nicholas C. Butzin   +3 more
doaj   +1 more source

A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection [PDF]

, 2016
Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia.
Beamer, Gillian, Curiel, David T, Debatis, Michele, Dmitriev, Igor P, Kashentseva, Elena A, Kim, Hyeun Bum, Schmidt, Diane J, Shoemaker, Charles B, Steele, Jennifer A, Sun, Xingmin, Tremblay, Jacqueline M, Tzipori, Saul, Wang, Yaunkai   +12 more
core   +2 more sources

Aptamers: Design, Theory, and Applications to Diagnosis and Therapy for Diseases

MedComm, Volume 6, Issue 5, May 2025.
A summary showing potential applications of nucleic acid aptamers and antidotes. Aptamers and antidotes can be utilized in biomedical diverse areas. Nucleic acid aptamers have applications in several biomedical disciplines including theragnostic, molecular imaging, drug delivery, biosensors, and gene therapy. The therapeutic utilizes of aptamers can be
Sepideh Hassibian, Mahsa Amin, Seyed Mohammad Taghdisi, Elham Sameiyan, Reza Ghaffari, Mona Alibolandi, Mohammad Ramezani, Khalil Abnous, Seyed Mohsen Dehnavi   +8 more
wiley   +1 more source

Structural insights into chaperone addiction of toxin-antitoxin systems

Nature Communications, 2019
SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC).
Valérie Guillet, Patricia Bordes, Cécile Bon, Julien Marcoux, Virginie Gervais, Ambre Julie Sala, Suzana Dos Reis, Nawel Slama, Israel Mares-Mejía, Anne-Marie Cirinesi, Laurent Maveyraud, Pierre Genevaux, Lionel Mourey   +12 more
doaj   +1 more source

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function

Toxins, 2020
Botulinum neurotoxin (BoNT) serotype E is one of three serotypes that cause the preponderance of human botulism cases and is a Tier 1 Select Agent. BoNT/E is unusual among BoNT serotypes for its rapid onset and short duration of intoxication.
Jacqueline M. Tremblay, Edwin Vazquez-Cintron, Kwok-Ho Lam, Jean Mukherjee, Daniela Bedenice, Celinia A. Ondeck, Matthieu T. Conroy, Skylar M. L. Bodt, Brittany M. Winner, Robert P. Webb, Konstantin Ichtchenko, Rongsheng Jin, Patrick M. McNutt, Charles B. Shoemaker   +13 more
doaj   +1 more source

A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons [PDF]

, 2008
Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Bal Ram Singh, Dan Li, James Keller, Michael Adler, Peng Zhang, Prabhati Ray, Radharaman Ray   +6 more
core   +1 more source

Macromolecular crystallography at Elettra: current and future perspectives

Journal of Synchrotron Radiation, Volume 32, Issue 3, Page 757-765, May 2025.
The XRD2 beamline at Elettra‐Sincrotrone Trieste has been in operation since 2018 and is dedicated to macromolecular crystallography for both academic and industrial research, a role partially fulfilled, before 2018, by XRD1, a general‐purpose diffraction beamline.
Raghurama P. Hegde, Nicola Demitri, Annie Héroux, Alessandro Olivo, Giorgio Bais, Michele Cianci, Paola Storici, Dan-George Dumitrescu, Nishant Kumar Varshney, Balasubramanian Gopal, D. D. Sarma, Lisa Vaccari, Silvia Onesti, Maurizio Polentarutti   +13 more
wiley   +1 more source

Wound botulism caused by Clostridium subterminale after a heroin injection

Infectious Disease Reports, 2018
Botulism is caused by toxin production from many species of Clostridium, most commonly Clostridium botulinum as well as C. baratii and C. butyricum. Development of wound botulism is associated with injection drug users but has also been described in ...
Paris A. Cook, Aimee Mishler, Dan Quan, Ashley Parrish-Garcia   +3 more
doaj   +1 more source

Gut‐on‐a‐chip platforms: Bridging in vitro and in vivo models for advanced gastrointestinal research

Physiological Reports, Volume 13, Issue 9, May 2025.
Abstract The gastrointestinal (GI) tract plays a critical role in nutrient absorption, immune responses, and overall health. Traditional models such as two‐dimensional cell cultures have provided valuable insights but fail to replicate the dynamic and complex microenvironment of the human gut. Gut‐on‐a‐chip platforms, which incorporate cells located in
Awurama Ofori‐Kwafo, Indira Sigdel, Earshed Al Mamun, Jasenka Zubcevic, Yuan Tang   +4 more
wiley   +1 more source