Results 91 to 100 of about 32,139 (221)
Summary Arbuscular mycorrhizal fungi (AMF) are widespread plant symbionts that enhance nutrient acquisition and influence ecosystem productivity. Previous chromosome‐level assemblies of the model species Rhizophagus irregularis revealed a two‐compartment genome architecture (active A and repressed B chromatin compartments), yet its conservation across ...
Ken Mugambi +10 more
wiley +1 more source
The vapB-vapC operon of Acidovorax citrulli functions as a bona-fide toxin-antitoxin module
Toxin–antitoxin systems are commonly found on plasmids and chromosomes of bacteria and archaea. These systems appear as biscystronic genes encoding a stable toxin and a labile antitoxin, which protects the cells from the toxin’s activity. Under specific,
Reut eShavit +4 more
doaj +1 more source
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino +2 more
wiley +1 more source
PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li +10 more
wiley +1 more source
Higher-Order Structure in Bacterial VapBC Toxin-Antitoxin Complexes
Toxin-antitoxin systems are widespread in the bacterial kingdom, including in pathogenic species, where they allow rapid adaptation to changing environmental conditions through selective inhibition of key cellular processes, such as DNA replication or ...
Brodersen, Ditlev E +3 more
core +1 more source
ABSTRACT The role of microbes in cancer is gaining attention these days, especially in the context of tumor‐associated biofilms and dysbiotic microbiota. Biofilm‐producing microorganisms, such as Fusobacterium nucleatum and Helicobacter pylori, trigger oncogenic inflammation and immune evasion in tumor initiation and progression, and in the development
Saikat Mazumder +14 more
wiley +1 more source
Silk fibroin coatings transform inert 3D‐printed porous titanium scaffolds into intelligent, bioactive implants. Leveraging its pH‐responsive structure and tunable degradation, silk fibroin enables spatiotemporal drug delivery, promotes osteoblast activity, and modulates macrophage immunity.
Jiajun Liu +15 more
wiley +1 more source
de novo synthesis of a bacterial toxin/antitoxin system [PDF]
The prevalence of toxin/antitoxin (TA) systems in almost all genomes suggests they evolve rapidly. Here we show that an antitoxin from a type V system (GhoS, an endoribonuclease specific for the mRNA of the toxin GhoT) can be converted into a novel toxin
Soo, Valerie WC +3 more
core +1 more source
Toxin-antitoxin cassettes identified by TA finder in investigated Salmonella strains with functional classification of candidate toxin and antitoxin proteins.
Taruna Anand (828898) +4 more
core +1 more source
conformational changes of antitoxin HigA by binding of toxin HigB
학위논문(박사)--아주대학교 일반대학원 :분자과학기술학과,2021. 2General Introduction 1 Shigella flexneri 1 Persistent cells and toxin-antitoxin system 2 Multidrug resistance and multidrug tolerance 5 Six types of toxin-antitoxin system 7 Conditional cooperativity 10 Chapter
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