Results 131 to 140 of about 2,263 (168)
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In vitro and in vivo antitrypanosomal activity of Xanthium strumarium leaves
Journal of Ethnopharmacology, 1995Antitrypanosomal activity of crude 50% ethanolic extract of Xanthium strumarium leaves was studied in vitro and in vivo. The extract exhibited trypanocidal activity at all four concentrations tested i.e. 5, 50, 500 and 1000 micrograms/ml, in vitro. In vivo trial revealed that the extract exerted antitrypanosomal effect at dosage of 100, 300 and 1000 mg/
S K Dwivedi, S K Dwivedi
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Antitrypanosomal Activity of Phosphonylmethoxyalkylpurines
The Journal of Parasitology, 1994Phosphonylmethoxyalkylpurines and -pyrimidines exhibit potent activity against a broad spectrum of DNA viruses. We evaluated some of these nucleotide analogues for antitrypanosomal activity in vitro and in mice. The most active compounds were (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl) adenine (HPMPA) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-2,6-
R, Kaminsky, E, Zweygarth, E, De Clercq
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Antitrypanosomal activity of camptothecin analogs
Biochemical Pharmacology, 1995African trypanosomes (Trypanosoma brucei species) are parasitic protozoa that cause lethal diseases in humans and cattle. Previous studies showed that camptothecin, a potent and specific inhibitor of DNA topoisomerase I, is cytotoxic to African trypanosomes and related pathogenic hemoflagellates (Bodley AL and Shapiro TA, Proc Natl Acad Sci USA 92 ...
Annette L. Bodley +3 more
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Antiplasmodial and Antitrypanosomal Activity of Pyrethrins and Pyrethroids
Journal of Agricultural and Food Chemistry, 2011In a screen of 1800 plant and fungal extracts for antiplasmodial, antitrypanosomal, and leishmanicidal activity, the n-hexane extract of Chrysanthemum cinerariifolium (Trevir.) Vis. flowers showed strong activity against Plasmodium falciparum. We isolated the five pyrethrins [i.e., pyrethrin II (1), jasmolin II (2), cinerin II (3), pyrethrin I (4), and
Hata, Y. +6 more
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Antitrypanosomal and Antileishmanial Activities
2018The so-called neglected tropical diseases, which are endemic in 149 tropical and subtropical countries, affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain.
Sanchez Alberti, Andrés +3 more
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Antitrypanosomal activity of quaternary naphthalimide derivatives
Bioorganic & Medicinal Chemistry Letters, 2007Sleeping sickness caused by Trypanosoma brucei gambiense and rhodesiense is fatal if left untreated. Due to the toxicity of drugs currently used and the emerging resistance against these drugs new lead compounds are urgently needed. Within the frame of a broad screening program for drugs with antitrypanosomal activity, some highly potent tertiary and ...
Mathias, Muth +6 more
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Prolylisoxazoles: Potent Inhibitors of Prolyloligopeptidase with Antitrypanosomal Activity.
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Bal, Gunther +7 more
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Effect of verapamil on antitrypanosomal activity of drugs in mice
Acta Tropica, 1993The effects of verapamil on drug responses of Trypanosoma brucei brucei were studied to determine whether drug resistance of this organism could be related to expression of a drug resistance gene as has been described for drug-resistant cancer cells and malaria.
S A, Agbe, K L, Yielding
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Antitrypanosomal activity of new semi‐synthetic bergenin derivatives
Chemical Biology & Drug Design, 2021AbstractBergenin and 11‐O‐(4'‐O‐methyl galloyl)‐bergenin, previously isolated from Crassula capitella extract, were used as starting materials for the synthesis of eight derivatives; four derivatives 2a–2d were synthesized from bergenin through the formation of ester derivatives and four alkyl derivatives 4a–4d were synthesized from 11‐O‐(4′‐O‐methyl ...
Seham S, El-Hawary +6 more
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Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity
Bioorganic & Medicinal Chemistry Letters, 2006A series of polyaminoguanidines and polyaminobiguanides were synthesized and evaluated as potential antitrypanosomal agents. These analogues inhibit trypanothione reductase (TR) with IC50 values as low as 0.95 microM, but do not inhibit the closely related human enzyme glutathione reductase (GR).
Xiangdong, Bi +4 more
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