Results 191 to 200 of about 37,127 (212)

Identification of novel multitarget antitubercular inhibitors against mycobacterial peptidoglycan biosynthetic Mur enzymes by structure-based virtual screening

Journal of Biomolecular Structure and Dynamics, 2021
Current therapeutic strategies for several diseases, including Mycobacterium tuberculosis infection, have evolved from an initial single-target treatment to a multitarget one.
Madhulata Kumari, N. Subbarao
semanticscholar   +1 more source

An overview of new antitubercular drugs, drug candidates, and their targets

Medicinal research reviews (Print), 2020
The causative agent of tuberculosis (TB), Mycobacterium tuberculosis and more recently totally drug‐resistant strains of M. tuberculosis, display unique mechanisms to survive in the host.
A. Bahuguna, D. Rawat
semanticscholar   +1 more source

Pyrazole-coumarin and pyrazole-quinoline chalcones as potential antitubercular agents.

Archiv der Pharmazie, 2020
Pyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two series of novel pyrazole-coumarin chalcones and pyrazole-quinoline chalcones were synthesized using multiple-step reactions.
Gautam Kumar, Vagolu Siva Krishna, D. Sriram, S. Jachak   +3 more
semanticscholar   +1 more source

Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 ΔilaR.

Journal of Natural Products, 2020
Tuberculosis (TB) ranks as the leading cause of death from a single infectious agent (ranking more lethal than HIV/AIDS) over the course of the past decade. More concerning is that reports of multi-drug-resistant (MDR) and extensively drug-resistant (XDR)
Changli Sun, Zhi-yong Liu, Xiangcheng Zhu, Zhiying Fan, Xuanmei Huang, Qiaoling Wu, Xiaohong Zheng, Xiangjing Qin, Tianyu Zhang, Hua Zhang, J. Ju, Junying Ma   +11 more
semanticscholar   +1 more source

Synthesis, antitubercular evaluation and molecular docking studies of phthalimide bearing 1,2,3-triazoles

Synthetic Communications, 2019
In a search for safer and potent antitubercular agents, here a library of newly substituted dioxoisoindolinylmethyl-triazolyl-N-phenylacetamide derivatives (5a–l) has been synthesized via click chemistry approach. All synthesized compounds were evaluated
Pramod S. Phatak, Rajubai D. Bakale, Sambhaji T. Dhumal, L. Dahiwade, P. Choudhari, Vagolu Siva Krishna, D. Sriram, K. Haval   +7 more
semanticscholar   +1 more source

Evaluation and Docking Study of Pyrazine Containing 1, 3, 4-Oxadiazoles Clubbed with Substituted Azetidin-2-one: A New Class of Potential Antimicrobial and Antitubercular

Drug Research, 2020
Background Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the main killers of people all over the world. The major hurdles with existing therapy are the lengthy regimen and appearance of multi drug resistant (MDR) and extensively drug ...
R. Das, D. Mehta
semanticscholar   +1 more source

Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora

Natural Product Research, 2020
Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds.
A. Macabeo, A. Flores, R. A. Fernandez, Simon Budde, Christian Faderl, H. Dahse, S. Franzblau   +6 more
semanticscholar   +1 more source

An Overview on Applications of SwissADME Web Tool in the Design and Development of Anticancer, Antitubercular and Antimicrobial agents: A Medicinal Chemist's Perspective

Journal of Molecular Structure, 2022
Bulti Bakchi, Am Krishna, Ekambarapu Sreecharan, Veeramallu Bala Jaya Ganesh, Muraboina Niharika, Suryadevara Maharshi, S. Puttagunta, D. K. Sigalapalli, Richie R. Bhandare, A. Shaik   +9 more
semanticscholar   +1 more source

Opportunities and challenges of using five‐membered ring compounds as promising antitubercular agents

Drug development research (Print), 2020
Tuberculosis (TB), a chronic infectious disease, is one of the greatest risks to human beings and 10 million people were diagnosed with TB and 1.6 million died from this disease in 2017. In addition, with the emergence of multidrug‐resistant tuberculosis
Mi Yan, Linlin Xu, Yinhu Wang, Jianhua Wan, Ting Liu, Wenjie Liu, Yichao Wan, Bin Zhang, Rongmei Wang, Qiang Li   +9 more
semanticscholar   +1 more source

Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents.

Journal of Natural Products, 2019
(+)-Usnic acid, a product of secondary metabolism in lichens, has displayed a broad range of biological properties such as antitumor, antimicrobial, antiviral, anti-inflammatory, and insecticidal activities. Interested by these pharmacological activities
P. Bangalore, S. K. Vagolu, R. K. Bollikanda, Dileep K. Veeragoni, P. Choudante, S. Misra, D. Sriram, B. Sridhar, S. Kantevari   +8 more
semanticscholar   +1 more source