Results 191 to 200 of about 25,061 (213)
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ChemInform Abstract: Quinolizidine Derivatives with Antitubercular Activity.
ChemInform, 1994AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
VAZZANA, IANA +5 more
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Antitubercular Marine Natural Products
Current Medicinal Chemistry, 2018Due to the importance of nature as a source of new drug candidates, the purpose of this article is to emphasize the marine natural products, which exhibit antitubercular activity, published between January 2000 and May 2016, with 138 quotations to 250 compounds obtained from marine resources.
Yonghong Liu +3 more
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Resistance to Antitubercular Drugs
1998Historians established the existence of endemic tuberculosis from Egyptian mummies dating from 2000 to 4000 B.C. (reviewed by Bloom and Murray, 1992). Tuberculosis was prevalent in Europe throughout the middle ages. Newly crowned kings of England and France were believed to have special healing powers and the most desired treatment of tuberculosis was ...
Luiz Augusto Basso, John S. Blanchard
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Clinical Pharmacology of Antitubercular Drugs
Pediatric Clinics of North America, 1983Isoniazid, rifampin, and ethambutol are the three major drugs used in the modern treatment of patients with tuberculosis. Data on these drugs in children have been derived primarily from their clinical use in pediatrics and extrapolation from experiences in adults. A number of questions remain concerning the clinical pharmacology and appropriate use of
Jeffrey L. Blumer, Michael D. Reed
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Polymorphism of the Antitubercular Isoxyl
Crystal Growth & Design, 2011Two polymorphs (Forms I and II) of the antitubercular drug isoxyl (N, N'-[4-(3-methylbutoxy)phenyl]thiourea) have been identified and characterized by powder and single crystal X-ray diffraction, thermal analysis (hot stage microscopy and differential scanning calorimetry), Fourier transform infrared spectroscopy and 13 C solid-state nuclear magnetic ...
Jinjing Li +4 more
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Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity
Journal of Medicinal Chemistry, 2015We conducted an evaluation of the phenoxyalkylbenzimidazole series based on the exemplar 2-ethyl-1-(3-phenoxypropyl)-1H-benzo[d]imidazole for its antitubercular activity. Four segments of the molecule were examined systematically to define a structure-activity relationship with respect to biological activity.
Jeffrey W. Cramer +12 more
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Multi-Target Antitubercular Drugs
Current Topics in Medicinal Chemistry, 2018Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this ...
Luciana Scotti +3 more
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Triazole: A Promising Antitubercular Agent
Chemical Biology & Drug Design, 2015Tuberculosis is a contagious disease with comparatively high mortality worldwide. The statistics shows that around three million people throughout the world die annually from tuberculosis and there are around eight million new cases each year, of which developing countries showed major share.
Srinivasa Budagumpi +3 more
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Paradoxical response to antitubercular drugs
The Indian Journal of Pediatrics, 1995Seven patients with paradoxical response to antitubercular drugs are reported. In three cases of intracranial tuberculomas, newer lesions appeared and in two cases preexisting tuberculomas enlarged. In two cases of tubercular meningitis, multiple tuberculomas appeared.
Ajay Bhutani +5 more
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Prospects for new antitubercular drugs
Current Opinion in Microbiology, 2004The inexorable rise in cases of tuberculosis worldwide, fuelled by the HIV epidemic, highlights the need for new drugs and particularly those that can shorten the duration of treatment. Clinical trials of existing broad-spectrum agents such as the fluoroquinolone moxifloxacin are proceeding, on the basis of efficacy in models of infection and ...
Clifton E. Barry, Ken Duncan
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