Results 221 to 230 of about 35,652 (265)

Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines

Bioorganic & Medicinal Chemistry, 2014
Novel riminophenazine derivatives, characterized by the presence of the basic and cumbersome quinolizidinylalkyl and pyrrolizidinylethyl moieties, have been synthesized and tested (Rema test) against Mycobacterium tuberculosis H37Rv and H37Ra, and six clinical isolates of Mycobacterium avium and Mycobacterium tuberculosis.
TONELLI, MICHELE, NOVELLI, FEDERICA, TASSO, BRUNO, Anna Sparatore, BOIDO, VITO, SPARATORE, FABIO, Sara Cannas, Paola Molicotti, Stefania Zanetti, Silvia Parapini, Roberta Loddo   +10 more
openaire   +4 more sources

ChemInform Abstract: Quinolizidine Derivatives with Antitubercular Activity.

ChemInform, 1994
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
VAZZANA, IANA, NOVELLI, FEDERICA, SPARATORE, FABIO, A. SPARATORE, G. FADDA, C. MANCA   +5 more
openaire   +5 more sources

Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 ΔilaR.

Journal of Natural Products, 2020
Tuberculosis (TB) ranks as the leading cause of death from a single infectious agent (ranking more lethal than HIV/AIDS) over the course of the past decade. More concerning is that reports of multi-drug-resistant (MDR) and extensively drug-resistant (XDR)
Changli Sun, Zhi-yong Liu, Xiangcheng Zhu, Zhiying Fan, Xuanmei Huang, Qiaoling Wu, Xiaohong Zheng, Xiangjing Qin, Tianyu Zhang, Hua Zhang, J. Ju, Junying Ma   +11 more
semanticscholar   +1 more source

Antitubercular Marine Natural Products

Current Medicinal Chemistry, 2018
Due to the importance of nature as a source of new drug candidates, the purpose of this article is to emphasize the marine natural products, which exhibit antitubercular activity, published between January 2000 and May 2016, with 138 quotations to 250 compounds obtained from marine resources.
Yonghong Liu, Jungfeng Wang, Lishu Wang, Juan Liu   +3 more
openaire   +3 more sources

Evaluation and Docking Study of Pyrazine Containing 1, 3, 4-Oxadiazoles Clubbed with Substituted Azetidin-2-one: A New Class of Potential Antimicrobial and Antitubercular

Drug Research, 2020
Background Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the main killers of people all over the world. The major hurdles with existing therapy are the lengthy regimen and appearance of multi drug resistant (MDR) and extensively drug ...
R. Das, D. Mehta
semanticscholar   +1 more source

Resistance to Antitubercular Drugs

1998
Historians established the existence of endemic tuberculosis from Egyptian mummies dating from 2000 to 4000 B.C. (reviewed by Bloom and Murray, 1992). Tuberculosis was prevalent in Europe throughout the middle ages. Newly crowned kings of England and France were believed to have special healing powers and the most desired treatment of tuberculosis was ...
Luiz Augusto Basso, John S. Blanchard
openaire   +3 more sources

Clinical Pharmacology of Antitubercular Drugs

Pediatric Clinics of North America, 1983
Isoniazid, rifampin, and ethambutol are the three major drugs used in the modern treatment of patients with tuberculosis. Data on these drugs in children have been derived primarily from their clinical use in pediatrics and extrapolation from experiences in adults. A number of questions remain concerning the clinical pharmacology and appropriate use of
Jeffrey L. Blumer, Michael D. Reed
openaire   +3 more sources

Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora

Natural Product Research, 2020
Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds.
A. Macabeo, A. Flores, R. A. Fernandez, Simon Budde, Christian Faderl, H. Dahse, S. Franzblau   +6 more
semanticscholar   +1 more source

Polymorphism of the Antitubercular Isoxyl

Crystal Growth & Design, 2011
Two polymorphs (Forms I and II) of the antitubercular drug isoxyl (N, N'-[4-(3-methylbutoxy)phenyl]thiourea) have been identified and characterized by powder and single crystal X-ray diffraction, thermal analysis (hot stage microscopy and differential scanning calorimetry), Fourier transform infrared spectroscopy and 13 C solid-state nuclear magnetic ...
Jinjing Li, Melgardt M. de Villiers, A. Michael Crider, Susan A. Bourne, Mino R. Caira   +4 more
openaire   +2 more sources

Multi-Target Antitubercular Drugs

Current Topics in Medicinal Chemistry, 2018
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this ...
Luciana Scotti, Marcus Tullius Scotti, Jéssika de Oliveira Viana, Hamilton Mitsugu Ishiki   +3 more
openaire   +3 more sources