Results 231 to 240 of about 35,652 (265)

Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity

Journal of Medicinal Chemistry, 2015
We conducted an evaluation of the phenoxyalkylbenzimidazole series based on the exemplar 2-ethyl-1-(3-phenoxypropyl)-1H-benzo[d]imidazole for its antitubercular activity. Four segments of the molecule were examined systematically to define a structure-activity relationship with respect to biological activity.
Jeffrey W. Cramer, Mai A. Bailey, Julie V. Early, Joshua Odingo, Prashant V. Desai, Megan Files, Thierry Masquelin, Juliane Ollinger, Tanya Parish, Torey Alling, N. Susantha Chandrasekera, Yulia Ovechkina, Philip Arthur Hipskind   +12 more
openaire   +3 more sources

Triazole: A Promising Antitubercular Agent

Chemical Biology & Drug Design, 2015
Tuberculosis is a contagious disease with comparatively high mortality worldwide. The statistics shows that around three million people throughout the world die annually from tuberculosis and there are around eight million new cases each year, of which developing countries showed major share.
Srinivasa Budagumpi, Siddappa A. Patil, Bhari Mallanna Nagaraja, Rangappa S. Keri   +3 more
openaire   +3 more sources

Prospects for new antitubercular drugs

Current Opinion in Microbiology, 2004
The inexorable rise in cases of tuberculosis worldwide, fuelled by the HIV epidemic, highlights the need for new drugs and particularly those that can shorten the duration of treatment. Clinical trials of existing broad-spectrum agents such as the fluoroquinolone moxifloxacin are proceeding, on the basis of efficacy in models of infection and ...
Clifton E. Barry, Ken Duncan
openaire   +3 more sources

Synthesis, antitubercular evaluation and molecular docking studies of phthalimide bearing 1,2,3-triazoles

Synthetic Communications, 2019
In a search for safer and potent antitubercular agents, here a library of newly substituted dioxoisoindolinylmethyl-triazolyl-N-phenylacetamide derivatives (5a–l) has been synthesized via click chemistry approach. All synthesized compounds were evaluated
Pramod S. Phatak, Rajubai D. Bakale, Sambhaji T. Dhumal, L. Dahiwade, P. Choudhari, Vagolu Siva Krishna, D. Sriram, K. Haval   +7 more
semanticscholar   +1 more source

Paradoxical response to antitubercular drugs

The Indian Journal of Pediatrics, 1995
Seven patients with paradoxical response to antitubercular drugs are reported. In three cases of intracranial tuberculomas, newer lesions appeared and in two cases preexisting tuberculomas enlarged. In two cases of tubercular meningitis, multiple tuberculomas appeared.
Ajay Bhutani, S. K. Gupta, Vinod Puri, Man Mohan Mehndiratta, Sushil Kumar, Chaitanaya Sharma   +5 more
openaire   +3 more sources

Mycothiol: A promising antitubercular target

Bioorganic Chemistry, 2014
Tuberculosis (TB) is the world's second commonest cause of death next to HIV/AIDS. The increasing emergence of multi drug resistance and the recalcitrant nature of persistent infections pose an additional challenge for the treatment of TB. Due to the development of resistance to conventional antibiotics there is a need for new therapeutic strategies to
Muthu K. Kathiravan, Shrikant Nilewar
openaire   +2 more sources

Opportunities and challenges of using five‐membered ring compounds as promising antitubercular agents

Drug development research (Print), 2020
Tuberculosis (TB), a chronic infectious disease, is one of the greatest risks to human beings and 10 million people were diagnosed with TB and 1.6 million died from this disease in 2017. In addition, with the emergence of multidrug‐resistant tuberculosis
Mi Yan, Linlin Xu, Yinhu Wang, Jianhua Wan, Ting Liu, Wenjie Liu, Yichao Wan, Bin Zhang, Rongmei Wang, Qiang Li   +9 more
semanticscholar   +1 more source

Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents.

Journal of Natural Products, 2019
(+)-Usnic acid, a product of secondary metabolism in lichens, has displayed a broad range of biological properties such as antitumor, antimicrobial, antiviral, anti-inflammatory, and insecticidal activities. Interested by these pharmacological activities
P. Bangalore, S. K. Vagolu, R. K. Bollikanda, Dileep K. Veeragoni, P. Choudante, S. Misra, D. Sriram, B. Sridhar, S. Kantevari   +8 more
semanticscholar   +1 more source

ChemInform Abstract: Quinazoline Derivatives with Antitubercular Activity.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Karel Waisser, Jaroslav Bažant, M. Slosarek, Jiřı́ Janota, Milan Pour, Jiří Kuneš   +5 more
openaire   +4 more sources

An Overview on Applications of SwissADME Web Tool in the Design and Development of Anticancer, Antitubercular and Antimicrobial agents: A Medicinal Chemist's Perspective

Journal of Molecular Structure, 2022
Bulti Bakchi, Ambati Dileep Krishna, Ekambarapu Sreecharan, Veeramallu Bala Jaya Ganesh, Muraboina Niharika, Suryadevara Maharshi, S. Puttagunta, D. K. Sigalapalli, Richie R. Bhandare, A. Shaik   +9 more
semanticscholar   +1 more source