Results 241 to 250 of about 35,652 (265)

Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis.

Future Medicinal Chemistry, 2019
AIM In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis.
Vitthal B. Makane, V. Krishna, E. V. Krishna, Manjulika Shukla, B. Mahizhaveni, S. Misra, S. Chopra, D. Sriram, V. N. Azger Dusthackeer, H. Rode   +9 more
semanticscholar   +1 more source

Dicationic liquid mediated synthesis of tetrazoloquinolinyl methoxy phenyl 4-thiazolidinones and their antibacterial and antitubercular evaluation

Synthetic Communications, 2019
In a search of new potentially active antitubercular agents here we have synthesized 3-substituted phenyl-2-(4-(tetrazolo[1,5-a]quinolin-4-ylmethoxy)phenyl)thiazolidin-4-ones (8a-l) and evaluated their antibacterial, particularly antitubercular activity.
Amarsinh R. Deshmukh, Sambhaji T. Dhumal, Laxman U. Nawale, V. Khedkar, D. Sarkar, R. Mane   +5 more
semanticscholar   +1 more source

Synthesis of Adamantane Aminoethers with Antitubercular Potential

Medicinal Chemistry, 2017
Intrigued by the fact that aminoadamantane derivatives, bearing the active 1,2-ethylenediamine moiety, are promising antitubercular agents, we report herein the synthesis and the antitubercular evaluation of N,N'-substituded-4,4'-[adamantane-2,2-diyl]bis(phe-noxyalkylamines) 1a-g, N,N'-substituded-4,4'-[adamantane-1,3-diyl]bis(phenoxyalkylamines) 2a-f,
Foscolos, A.-S., Papanastasiou, I., Tsotinis, A., Kolocouris, N., Foscolos, G.B., Vocat, A., Cole, S.T.   +6 more
openaire   +3 more sources

Antitubercular Potential of Novel Isoxazole Encompassed 1, 2, 4- Triazoles: Design, Synthesis, Molecular Docking Study and Evaluation of Antitubercular Activity

, 2020
Decaprenylphosphoryl-β-D-ribose epimerase (DprE1), a flavoprotein enzyme engaged in the biosynthesis of decaprenylphosphoryl-β-D-arabinofuranose (DPA), is the only contributor of arabinose residues which is fundamental for the mycobacterium cell wall ...
N. Ganesh, A. S, Manisha Singh, V. M. Chandrashekar, G. Pujar   +4 more
semanticscholar   +1 more source

Antitubercular diterpenoids from Vitex trifolia

Phytomedicine, 2013
A new halimane diterpenoid, 13-hydroxy-5(10),14-halimadien-6-one (1) and two new labdane diterpenoids, 6α,7α-diacetoxy-13-hydroxy-8(9),14-labdadien (2) and 9-hydroxy-13(14)-labden-15,16-olide (3), were isolated for the first time, along with fifteen known compounds, from the hexane soluble fraction of methanolic extract of Vitex trifolia leaves.
Madan M. Gupta, Jay Prakash Thakur, Neerja Tiwari, Dharmendra Saikia   +3 more
openaire   +3 more sources

Dry powder inhalers of antitubercular drugs.

Tuberculosis, 2022
Nidhi Nainwal, Yuwanshi Sharma, Vikas Jakhmola   +2 more
semanticscholar   +1 more source

iAtbP-Hyb-EnC: Prediction of antitubercular peptides via heterogeneous feature representation and genetic algorithm based ensemble learning model

Comput. Biol. Medicine, 2021
S. Akbar, Ashfaq Ahmad, Maqsood Hayat, A. Rehman, Salman Khan, Farman Ali   +5 more
semanticscholar   +1 more source

Synthesis, biological evaluation and molecular docking studies of new pyrazolines as an antitubercular and cytotoxic agents.

Infectious Diseases - Drug Targets, 2019
A series of new pyrazolines containing 2,5-dichloro-3-acetylthiophene chalcone moiety (PZT1-PZT20) have been synthesized, characterized by 1HNMR and 13CNMR and evaluated for them in vitro antitubercular activity against M.
B. V. Lokesh, Y. Prasad, A. Shaik
semanticscholar   +1 more source

Antitubercular Constituents ofValeriana laxiflora

Planta Medica, 2004
Antitubercular bioassay-guided fractionation of the n-hexane- and CH (2)Cl (2)-soluble extracts of the above-ground biomass and roots of Valeriana laxiflora led to the isolation of a new iridolactone, (4R,5R,7S,8S,9S)-7-hydroxy-8-hydroxymethyl-4-methyl-perhydrocyclopenta[ c]pyran-1-one ( 1), and a new lignan, (+)-1-hydroxy-2,6-bis- epi-pinoresinol ( 2),
Gu J.Q., Wang Y., Franzblau S.G., Montenegro Rizzardini, Gloria, Yang D., Timmermann B.N.   +5 more
openaire   +4 more sources

Synthesis, structural, biological andin silicostudies of new 5-arylidene-4-thiazolidinone derivatives as possible anticancer, antimicrobial and antitubercular agents

New Journal of Chemistry, 2019
Thiazolidinone–sulfonamide hybrids emerged as promising anticancer and antitubercular agents, and their anticancer activity was confirmed by docking studies.
A. Sunil Kumar, Jyothi Kudva, B. Bharath, K. Ananda, Rajitha Sadashiva, S. Madan Kumar, B. Revanasiddappa, Vasantha Kumar, P. Rekha, Damodara Naral   +9 more
semanticscholar   +1 more source