Results 11 to 20 of about 3,270,661 (190)

Causality assessment, severity and preventability of adverse drug reactions due to first-line antitubercular agents [PDF]

Pharmaciana, 2022
TB (Tuberculosis) is a common infectious disease affecting humans since very long time. Multidrug therapy with its associated adverse drug reactions is one of the major concerns for the management of TB.
Gunjan Upadhyay, Apexa B Shukla, Darshan J Dave   +2 more
doaj   +1 more source

Microbial glycosylation of antitubercular agent chlorflavonin [PDF]

Journal of Bioscience and Bioengineering, 2023
Flavonoids have shown health-benefiting properties, such as antioxidative and anti-inflammatory activities, and are commonly used as nutraceuticals and pharmaceuticals. Although flavonoids are predominantly identified from plants, several filamentous fungal species have also been reported to produce bioactive flavonoids, including chlorflavonin from ...
Jie Ren, Jixun Zhan
openaire   +3 more sources

Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study

Journal of Nepal Medical Association, 2021
Introduction: Sputum non-conversion is smear positive tuberculosis despite anti-tubercular therapy. Various factors may lead to sputum non-conversion including resistance to anti-tubercular drugs, age, gender, disease severity, non-compliance, drugs ...
Naveen Prakash Shah, Anil Regmi, Aakash Acharya, Jwala K.C. , Bidur Khatiwada, Meera Hada   +5 more
doaj   +1 more source

Synthesis of functionalized sulfonamides as antitubercular agents

Phosphorus Sulfur and Silicon and the Related Elements, 2023
Using up-to-date methods for synthesis and analysis, 51 sulfonamides were prepared for use as tools in antitubercular drug discovery. The synthetic efforts were centered on varying substituents at three key structural units implicated in antimicrobial ...
M. Hearn, Catherine D. Pugh, M. Cynamon
semanticscholar   +1 more source

Development of 6-Methanesulfonyl-8-nitrobenzothiazinone Based Antitubercular Agents.

ACS Medicinal Chemistry Letters, 2022
The 6-trifluoro substituted 8-nitrobenzothiazinones (BTZs) represent a novel type of antitubercular agents, and their high antimycobacterial activity is related to the inhibition of decaprenylphosphoryl-β-d-ribose 2'-oxidase (DprE1), an enzyme essential ...
Rui Shi, Bin Wang, G. Stelitano, Xiaomei Wu, Yuanyuan Shan, Yue Wu, Xin Wang, L. Chiarelli, Yu Lu, Chunhua Qiao   +9 more
semanticscholar   +1 more source

New Quinoline–Urea–Benzothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling

Pharmaceuticals, 2022
A series of 25 new benzothiazole–urea–quinoline hybrid compounds were synthesized successfully via a three-step synthetic sequence involving an amidation coupling reaction as a critical step.
Rashmika Moodley, Chakes Mashaba, Goitsemodimo H. Rakodi, Nomagugu B. Ncube, M. V. Maphoru, M. Balogun, Audrey Jordan, D. Warner, René Khan, Matshawandile Tukulula   +9 more
semanticscholar   +1 more source

Screening of the antimycobacterial activity of novel lipophilic agents by the modified broth based method

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2016
Most of the introduced susceptibility methods of Mycobacterium tuberculosis have some disadvantages for screening. Therefore, the selection of susceptibility assay for evaluating candidate agents must be determined case by case.
Mehdi Zandhaghighi, Kiarash Ghazvini, Zahra Meshkat, Seyed Abdolrahim Rezaee, Mohammad Derakhshan, Saman Soleimanpour, Farzin Hadizadeh   +6 more
doaj   +1 more source

Isoniazid associated psychosis: case series from a tertiary care centre

Open Journal of Psychiatry and Allied Sciences, 2018
Isoniazid (INH) is a commonly used first line antitubercular drug. INH associated psychosis is a rare psychiatric manifestation. We report two cases of pulmonary tuberculosis, where the patients developed psychosis after being given a therapeutic dose of
Hemendra Singh, Gayathri Devi HJ, Mamatha Chabaria, Kartik Shekar   +3 more
doaj   +1 more source

Novel Pyrimidines as Antitubercular Agents [PDF]

Antimicrobial Agents and Chemotherapy, 2018
ABSTRACT Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics. A triazine antitubercular hit led to the design of a related pyrimidine family.
Daigo, Inoyama, Steven D, Paget, Riccardo, Russo, Srinivasan, Kandasamy, Pradeep, Kumar, Eric, Singleton, James, Occi, Margareta, Tuckman, Matthew D, Zimmerman, Hsin Pin, Ho, Alexander L, Perryman, Véronique, Dartois, Nancy, Connell, Joel S, Freundlich   +13 more
openaire   +2 more sources

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

Pathogens, 2018
Mycobacterium tuberculosis is the causative agent of tuberculosis, an ancient disease which, still today, represents a major threat for the world population. Despite the advances in medicine and the development of effective antitubercular drugs, the cure
Davide M. Ferraris, Riccardo Miggiano, Franca Rossi, Menico Rizzi   +3 more
doaj   +1 more source