Results 61 to 70 of about 16,306 (216)

Nitrotriazole- and imidazole-based amides and sulfonamides as antitubercular agents. [PDF]

Antimicrob Agents Chemother, 2014
ABSTRACT Twenty-three 3-nitrotriazole-based and 2-nitroimidazole-based amides and sulfonamides were screened for antitubercular (anti-TB) activity in aerobic Mycobacterium tuberculosis H37Rv by using the BacTiter-Glo (BTG) microbial cell viability assay.
Papadopoulou MV, Bloomer WD, Rosenzweig HS, Arena A, Arrieta F, Rebolledo JC, Smith DK.   +6 more
europepmc   +4 more sources

Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole–Thiazole Hybrids as Potent Colon Cancer Inhibitors

ChemistryOpen, EarlyView.
Novel benzimidazothiazole–thiazole hybrids are synthesized and evaluated for anticancer activity against HCT‐116 colon cancer cells. Compound 16b shows superior cytotoxicity over doxorubicin. Molecular docking confirms strong binding to 6MTU protein, and ADMET profiling indicates favorable pharmacokinetics and low toxicity.
Bader Huwaimel, Amr S. Abouzied, Magdi E. A. Zaki, Abdulwahab Alamri, Basant Farag, Saad Alqarni, Sobhi M. Gomha   +6 more
wiley   +1 more source

Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, EarlyView.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

JAK Inhibitors for Treatment of SAPHO Syndrome: A Systematic Review of 72 Cases

ACR Open Rheumatology, Volume 7, Issue 10, October 2025.
Objective Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome usually involves bones, joints, and skin. Due to a lack of known pathogenesis and clinical trials, there is no standard treatment of SAPHO syndrome. Because none of the current treatments have a high efficacy and the risk of relapse is high, new treatment options for ...
Patrick Fazeli, Saeed Bahramian, Kimia Farahmand, Hamed Ghoshouni, Yalda Farahmand, Amirali Soheili, Leyla Bagheri, Huria Memari, Aydin Feyzi, Seyed Mohammad Vahabi   +9 more
wiley   +1 more source

Paradoxical Deterioration During Anti-Tuberculous Therapy in Non-HIV-Infected Patients with Pleural Tuberculosis: A Pragmatic Approach

European Journal of Case Reports in Internal Medicine, 2016
We report a case of paradoxical deterioration. A male patient diagnosed with pleural tuberculosis, but who was not infected with human immunodeficiency virus (HIV), experienced clinical deterioration 3 weeks after the initiation of anti-tuberculous ...
Luis Corral-Gudino, Alicia Rivas-Lazamares, Ana Gonzalez-Fernandez, Juan Carlos Hernando-Garcia   +3 more
doaj   +1 more source

Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents [PDF]

Royal Society Open Science, 2018
A series of 20 novel chromone embedded [1,2,3]-triazoles derivatives were synthesized via an easy and convenient synthetic procedure starting from 2-hydroxy acetophenone.
Viswanadh Nalla, Aslam Shaikh, Sanket Bapat, Renu Vyas, M. Karthikeyan, P. Yogeeswari, D. Sriram, M. Muthukrishnan   +7 more
doaj   +1 more source

Navigating Diagnostic Dilemmas in Cardiology: A Rare Case Report of Tuberculosis Presenting as a Cardiac Abscess

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Cardiac tuberculosis (TB) is a rare but important extrapulmonary form of TB that often presents diagnostic challenges due to nonspecific symptoms and its ability to mimic other cardiac conditions. We report the case of a 45‐year‐old woman with end‐stage renal disease secondary to granulomatosis with polyangiitis (GPA) who presented with fever ...
Fariba Bayat, Sepideh Jame Bozorgi, Mohammad Khani, Mehrdad Jafari Fesharaki, Abdoulhamid Bagheri, Elham Farahani   +5 more
wiley   +1 more source

Essential Thrombocythemia's Role in the Complex Landscape of Vasculitis: A Case Report

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Peripheral gangrenes have been sporadically documented as the initial presentation of essential thrombocythemia (ET), as exemplified in the preceding case reports. Nevertheless, the prevalence of vasculitis‐induced skin problems as the primary indication of ET has not been extensively examined.
Mohammad Reza Jafari Nakhjavani, Seyedeh‐Tarlan Mirzohreh, Sousan Kolahi, Mehrzad Hajialilo, Mehdi Jafarpour, Arezou Ghassembaglou, Mir Ali Sattary Oskouie, Tala Pourlak, Sepideh Tahsini Tekantapeh   +8 more
wiley   +1 more source

Widespread Verrucous Plaques of Chromoblastomycosis: A 12‐Year Diagnostic Odyssey

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Chromoblastomycosis is a deep fungal infection of the skin and subcutaneous tissue. This case underscores the critical importance of thorough laboratory investigations, particularly histopathology, in chronic dermatological conditions that mimic other granulomatous diseases.
Elisha Shrestha, Anupa Sharma, Manisha Gartaula, Aniket Basnet   +3 more
wiley   +1 more source

4-Substituted picolinohydrazonamides as a new class of potential antitubercular agents

European Journal of Medicinal Chemistry, 2020
The series of new 4-substituted picolinohydrazonamides were synthesized (6-25) and evaluated for tuberculostatic activity. Compounds having a hydrophilic cyclic amine such as morpholine and pyrrolidine at the end of the thiosemicarbazide chain, exhibited the highest antimycobacterial activity.
Krzysztof Bojanowski, Danuta Siluk, Dagmara Ziembicka, Henryk Foks, Agnieszka Głogowska, Katarzyna Gobis, Izabela Korona-Glowniak, Malwina Krause, Ewa Augustynowicz-Kopeć   +8 more
openaire   +3 more sources