Results 61 to 70 of about 22,631 (229)

Is the Pharmacokinetics of First-Line Anti-TB Drugs a Cause of High Mortality Rates in TB Patients Admitted to the ICU? A Non-Compartmental Pharmacokinetic Analysis

Tropical Medicine and Infectious Disease, 2023
Background: Patients with tuberculosis (TB) may develop multi-organ failure and require admission to intensive care. In these cases, the mortality rates are as high as 78% and may be caused by suboptimal serum concentrations of first-line TB drugs.
Francisco Beraldi-Magalhaes, Suzanne L. Parker, Cristina Sanches, Leandro Sousa Garcia, Brenda Karoline Souza Carvalho, Amanda Araujo Costa, Mariana Millan Fachi, Marcus Vinicius de Liz, Alexandra Brito de Souza, Izabella Picinin Safe, Roberto Pontarolo, Steven Wallis, Jeffrey Lipman, Jason A. Roberts, Marcelo Cordeiro-Santos   +14 more
doaj   +1 more source

Changes in chest X-ray findings in 1- and 2-month group after treatment initiation for suspected pulmonary tuberculosis [PDF]

The Korean Journal of Internal Medicine, 2020
Background/Aims Although re-evaluation of radiographic follow-up after 2 to 3 months of therapy is recommended for patients administered anti-tuberculosis medication owing to suspected pulmonary tuberculosis, reported findings are limited.
Jang Ho Lee, Ock-Hwa Kim, Yeon Joo Kim, Tae Sun Shim, Kyung-Wook Jo   +4 more
doaj   +1 more source

Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. [PDF]

, 2016
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole derivatives were initially studied for tuberculosis within a backup program for the clinical trial agent pretomanid (PA-824).
Blaser, Adrian, Denny, William A, Franzblau, Scott G, Gupta, Suman, Launay, Delphine, Ma, Zhenkun, Maes, Louis, Martin, Denis, O'Connor, Patrick D, Thompson, Andrew M, Wan, Baojie, Wang, Yuehong, Yardley, Vanessa   +12 more
core   +3 more sources

Intracellular and Extracellular Efficacy of Homoisoflavone Derivatives Against Mycobacterium Tuberculosis: Progress Toward Novel Antitubercular Agents

ChemMedChem, EarlyView.
A series of 42 homoisoflavones were synthesized and evaluated against Mycobacterium tuberculosis (Mtb). Three derivatives showed potent inhibition of Mtb strains. Evaluation in infected macrophages revealed promising intracellular activity, where one derivative featuring a nitrofuranyl and piperidine group emerges as the most promising.
Sanderson D. Calixto, Juliane S. Falcão, Stella S. Antunes, Marlon H. Araujo, Alexandre L. B. Cunha, David R. Martins, Sarah M. R. Nascimento, Thatiana L. B. V. Simão, Elena B. Lasunskaia, Nelilma C. Romeiro, Paulo R. R. Costa, Michelle F. Muzitano, Guilherme S. Caleffi   +12 more
wiley   +1 more source

Primary nasal tuberculosis: A case report [PDF]

Vojnosanitetski Pregled, 2013
Introduction. During the past two decades, tuberculosis (TBC) both pulmonary and extrapulmonary, has emerged to be a major health problem. Nasal tuberculosis is a specific inflammatory process which is, in most cases, joined by the inflammation of ...
Stojanović Jasmina, Belić Branislav, Mitrović Slobodanka, Stanković Predrag, Stojanović Stevan, Erdevički Ljiljana, Živić Ljubica, Arsenijević Snežana   +7 more
doaj   +1 more source

Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity [PDF]

, 2012
A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material.
Samadhiya Pushkal, Sharma Ritu, Srivastava Santosh K., Srivastava Savitri D.   +3 more
core   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Accepted Article.
Over the past decades extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including six‐, five‐, and four‐membered rings.
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Design of potent fluoro-substituted chalcones as antimicrobial agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Owing to ever-increasing bacterial and fungal drug resistance, we attempted to develop novel antitubercular and antimicrobial agents. For this purpose, we developed some new fluorine-substituted chalcone analogs (3, 4, 9–15, and 20–23) using a structure ...
Serdar Burmaoglu, Oztekin Algul, Arzu Gobek, Derya Aktas Anil, Mahmut Ulger, Busra Gul Erturk, Engin Kaplan, Aylin Dogen, Gönül Aslan   +8 more
doaj   +1 more source

Hepatitis C virus infection: a challenge in the complex management of two cases of multidrug-resistant tuberculosis

BMC Infectious Diseases, 2019
Background Multidrug-resistant tuberculosis (MDR-TB) requires lengthy use of second-line drugs, burdened by many side effects. Hepatitis C virus (HCV) chronic infection increases risk of drug-induced liver injury (DILI) in these patients.
Maria Musso, Silvia Mosti, Gina Gualano, Paola Mencarini, Rocco Urso, Piero Ghirga, Alessia Rianda, Franca Del Nonno, Delia Goletti, Fabrizio Palmieri   +9 more
doaj   +1 more source

Nitrotriazole- and imidazole-based amides and sulfonamides as antitubercular agents. [PDF]

Antimicrob Agents Chemother, 2014
ABSTRACT Twenty-three 3-nitrotriazole-based and 2-nitroimidazole-based amides and sulfonamides were screened for antitubercular (anti-TB) activity in aerobic Mycobacterium tuberculosis H37Rv by using the BacTiter-Glo (BTG) microbial cell viability assay.
Papadopoulou MV, Bloomer WD, Rosenzweig HS, Arena A, Arrieta F, Rebolledo JC, Smith DK.   +6 more
europepmc   +4 more sources