Results 61 to 70 of about 23,589 (259)

Hepatitis C virus infection: a challenge in the complex management of two cases of multidrug-resistant tuberculosis

BMC Infectious Diseases, 2019
Background Multidrug-resistant tuberculosis (MDR-TB) requires lengthy use of second-line drugs, burdened by many side effects. Hepatitis C virus (HCV) chronic infection increases risk of drug-induced liver injury (DILI) in these patients.
Maria Musso, Silvia Mosti, Gina Gualano, Paola Mencarini, Rocco Urso, Piero Ghirga, Alessia Rianda, Franca Del Nonno, Delia Goletti, Fabrizio Palmieri   +9 more
doaj   +1 more source

A truncated lipoglycan from mycobacteria with altered immunological properties [PDF]

, 2010
Maintenance of cell-wall integrity in Mycobacterium tuberculosis is essential and is the target of several antitubercular drugs. For example, ethambutol targets arabinogalactan and lipoarabinomannan (LAM) biosynthesis through the inhibition of several ...
Alderwick, Luke J., Appelmelk, B. J., Besra, Gurdyal S, Bhatt, Apoorva, Birch, Helen, Eggeling, Lothar, Geurtsen, J, Maaskant, J, Nigou, Jerome, Singh, Albel   +9 more
core   +2 more sources

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Is the Pharmacokinetics of First-Line Anti-TB Drugs a Cause of High Mortality Rates in TB Patients Admitted to the ICU? A Non-Compartmental Pharmacokinetic Analysis

Tropical Medicine and Infectious Disease, 2023
Background: Patients with tuberculosis (TB) may develop multi-organ failure and require admission to intensive care. In these cases, the mortality rates are as high as 78% and may be caused by suboptimal serum concentrations of first-line TB drugs.
Francisco Beraldi-Magalhaes, Suzanne L. Parker, Cristina Sanches, Leandro Sousa Garcia, Brenda Karoline Souza Carvalho, Amanda Araujo Costa, Mariana Millan Fachi, Marcus Vinicius de Liz, Alexandra Brito de Souza, Izabella Picinin Safe, Roberto Pontarolo, Steven Wallis, Jeffrey Lipman, Jason A. Roberts, Marcelo Cordeiro-Santos   +14 more
doaj   +1 more source

Antituberculosis Activity of Brotowali (Tinospora Crispa) Extract and Fractions Against Mycobacterium Tuberculosis Using Microplate Alamar Blue Assay Method [PDF]

, 2017
Tuberculosis (TB), in which caused by pathogenic bacteria, Mycobacterium tuberculosis, has become the major causes of death among all of infectious diseases.
Irianti, T. (Tatang), Kaneko, T. (Takushi), Nuryastuti, T. (Titik), Ritmaleni, R. (Ritmaleni), Wahyuningrum, R. (Retno), Wahyuono, S. (Subagus)   +5 more
core  

Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, EarlyView.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

Mycobacterium avium Infection in a Domestic Shorthair Cat Following Subdermal Hyaluronic Acid Filler Injection

Veterinary Ophthalmology, EarlyView.
ABSTRACT Objective To describe the diagnosis and treatment of a Mycobacterium avium (M. avium) infection in a cat following subdermal hyaluronic acid (HA) filler injection. Animal Studied A five‐year‐old spayed female domestic shorthair cat with chronic inferior lateral entropion and chronic feline atopic skin syndrome (FASS).
Alexandra E. Bergen, Callie Miller, J. Seth Eaton, Lara M. Tomich, Jennifer L. Heyward, Taylor A. Opgenorth   +5 more
wiley   +1 more source

Drug delivery systems for potential treatment of intracellular bacterial infections. [PDF]

, 2010
Despite the advent of a considerable number of new antibiotics, treatment of intracellular pathogens still represents a major pharmaceutical challenge.
Ariza, J. (J.), Blanco-Prieto, M.J. (María José), Gamazo, C. (Carlos), Imbuluzqueta, E. (Edurne)   +3 more
core   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum [PDF]

, 2018
Background: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs.
A Gómez-Zavaglia, A Ismael, A Ismael, A Paulo, A Siriwardana, AM Dondorp, AM Dondorp, António Sebastião Rodrigues, B Weniger, B Witkowski, B Witkowski, Bruno Guerreiro, C Amaratunga, C Amaratunga, D Ménard, EA Ashley, ES Schaffert, F Ariey, F Nogueira, F Teuscher, Fatima Nogueira, FG Baptista, H Noedl, H Noedl, H Singh, HM Ismail, I Fernández, J Adamec, J Jourdan, J Straimer, J Straimer, J Straimer, J Straimer, JL Vennerstrom, K Chauhan, K Chauhan, K Chotivanich, KM Tun, L Lobo, LH Carvalho, Lis Lobo, Lília I. L. Cabral, M Drąg-Zalesińska, M Machado, M Mota, M Tukulula, MA Fügi, Maria Inês Sena, Maria L. S. Cristiano, MD Spring, N Thuy-Nhien, NCP Araújo, PB Mohite, PM O’Neill, PN Soh, RJ Herr, RS Upadhayaya, S Arulmurugan, S Chaorattanakawee, S Nwaka, S Takala-Harrison, S Takala-Harrison, SA Santos, SD Fontaine, T Yang, TNC Wells, Valter Ferreira de Andrade-Neto, VS de Sena Pereira, W Peters, WA Kite, World Health Organization, X Fan, Y Lubell, Y Tang, Z Li, Z Wang   +75 more
core   +2 more sources