Results 61 to 70 of about 20,345 (152)

Synthesis and Biological Evaluation of 2-(3-Fluoro-4-nitro phenoxy)-N-phenylacetamide Derivatives as Novel Potential Affordable Antitubercular Agents

Molecules, 2012
A novel series of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide compounds were designed, synthesized and in vitro assessed for their antitubercular activities by a microdilution method.
Yu-Quan Wei, Tao Yang, Jian-Zhong Yang, Wei-Yi Pi, Ying-Hong Yang, You-Fu Luo, Yong Deng, Yan-Ni Lin, Wei Ang   +8 more
doaj   +1 more source

Cutaneous adverse drug reactions in patients with peripheral blood eosinophilia during antituberculosis treatment [PDF]

The Korean Journal of Internal Medicine, 2019
Background/Aims Peripheral eosinophilia during tuberculosis (TB) treatment is common, but has not been fully evaluated. The aim of this study was to determine the prevalence and clinical significance of peripheral blood eosinophilia in patients ...
Tae-Ok Kim, Hong-Joon Shin, Yu-Il Kim, Sung-Chul Lim, Young-Il Koh, Yong-Soo Kwon   +5 more
doaj   +1 more source

Knowledge, Attitude, and Practice of Medication Use During Pregnancy: A Cross‐Sectional Study in Western Uganda

Health Science Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Background Medication use (MU) during pregnancy can increase the risk of maternal and fetal health consequences. Women's knowledge, attitude, and practice (KAP) regarding safe MU can influence pregnancy outcomes. The study aimed to assess and explore women's KAP regarding safe MU during pregnancy and identify possible determinants.
Musiime Brian, Narayana Goruntla, Bhavana Reddy Bommireddy, Bhavani Mopuri, Easwaran Vigneshwaran, Mohammad Jaffar Sadiq Mantargi, Vishnuvandana Bandaru, Joseph Obiezu Chukwujekwu Ezeonwumelu, Sarad Pawar Naik Bukke, Tadele Mekuriya Yadesa, Ebere Emilia Ayogu   +10 more
wiley   +1 more source

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest. [PDF]

, 2019
In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents.
Cole, Stewart T, Georgiadis, Markos-Orestis, Ioannidou, Vaya, Karakitsios, Evangelos, Kelly, John M, Komiotis, Dimitri, Kourbeli, Violeta, Papanastasiou, Ioannis, Taylor, Martin C, Tsotinis, Andrew, Vocat, Anthony   +10 more
core   +1 more source

Drug‐Induced Renal Vasculitis: Etiology, Pathogenesis, Clinical Manifestations, and Therapeutic Approaches—A Narrative Review

Health Science Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Background and Aims Drug‐induced renal vasculitis arises from various medications that cause immunological dysregulation or direct vascular damage, leading to inflammation and thrombosis. Clinical manifestations vary widely, from mild constitutional symptoms to severe organ dysfunction. This review aims to thoroughly explore drug‐induced renal
Hashim Mohamed Siraj, Masab Ali, Sampda Sanjaykumar Sharma, Afreen Begum, Muhammad Husnain Ahmad, Hassan Muhammad, Roba Kamaleldin Moustafa Kamel Aref Elsayed, Muhammad Hamza Tahir   +7 more
wiley   +1 more source

Multiorgan tuberculosis [PDF]

Vojnosanitetski Pregled, 2002
Tuberculosis is an unusual infectious disease because of the latent period between the infection and the appearance of the disease may be prolonged for many weeks, months, or years as it is in case of the secondary tuberculosis.
Đokić Milomir, Bojić Ivanko, Mikić Dragan, Mladenović Ljubiša, Begović Vesna, Kuprešanin Srđan, Mirović Veljko, Dimitrijević Jovan   +7 more
doaj   +1 more source

Antitubercular potential and pH‐driven mode of action of salicylic acid derivatives

FEBS Open Bio, Volume 15, Issue 3, Page 383-398, March 2025.
Salicylic acid (SA), its two iodinated analogues 5ISA and 3,5diISA, as well as the anti‐inflammatory drug aspirin (ASP), are anti‐TB drugs that disrupt the intrabacterial pH homeostasis of Mycobacterium tuberculosis under in vitro conditions mimicking the endolysosomal pH of macrophages.
Janïs Laudouze, Thomas Francis, Emma Forest, Frédérique Mies, Jean‐Michel Bolla, Céline Crauste, Stéphane Canaan, Vadim Shlyonsky, Pierre Santucci, Jean‐François Cavalier   +9 more
wiley   +1 more source

Effect of tylophora asthmatica on hepatotoxicity induced by antitubercular drugs in albino rats [PDF]

, 2016
Background: The burden of metabolism and exposure to dangerous chemicals make liver vulnerable to variety of disorders like acute or chronic inflammation, toxin/ drug related hepatitis or cirrhosis. Tuberculosis is a common problem in India and worldwide.
Chandrakapure, Ajay R., Deshmukh, Vinod S., Motghare, Vijay M., Padwal, Sudhir L., Turankar, Avinash V.   +4 more
core   +3 more sources

Flavin‐Dependent Nitroreductases: Privileged Enzymes for Chemical and Photochemical Synthesis

ChemCatChem, Volume 17, Issue 5, March 6, 2025.
This review summarizes the functional, structural, and mechanistic properties of flavin‐dependent nitroreductases and highlights their usefulness for the synthesis of nitrogen‐containing compounds. Recent advances in enzyme and cofactor engineering, as well as in the use of nitroreductases in photobiocatalytic approaches, are emphasized.
Sara Russo, Alejandro Prats Luján, Marco W. Fraaije, Gerrit J. Poelarends   +3 more
wiley   +1 more source

DEVELOPMENT OF NEW PYRAZOLE HYBRIDS AS ANTITUBERCULAR AGENTS: SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDY [PDF]

, 2017
Objective: synthesis of new 1, 3-diphenyl pyrazole derivatives 9(a-f) and 10(a-f) using molecular hybridization approach for antitubercular and cytotoxic studies.Methods: The structures of synthesized compounds were confirmed by 1H-NMR, 13C-NMR and mass ...
Lokwani, Deepak K., Mokale, Santosh N., Shaikh, Sameer I., Zaheer, Zahid   +3 more
core   +1 more source