Results 81 to 90 of about 22,631 (229)

Novel Quinazolinones Active against Multidrug‐Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin‐Binding Protein 1A as a Potential Target

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
Quinazolinone‐based compounds emerge as potent antimycobacterial agents, showing low minimum inhibitory concentrations against drug‐resistant Mycobacterium tuberculosis. Molecular modeling uncovers a novel allosteric site in PonA1 targeted by these derivatives.
Marek Kerda, Daria Nawrot, Petr Šlechta, Miroslav Domanský, Asal Askari, Hanieh Kamangar, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Ingrid Hlbočanová, Miloslav Macháček, Matteo Mori, Fiorella Meneghetti, Martin Doležal, Jan Zitko, Ghada Bouz   +15 more
wiley   +1 more source

Paradoxical Deterioration During Anti-Tuberculous Therapy in Non-HIV-Infected Patients with Pleural Tuberculosis: A Pragmatic Approach

European Journal of Case Reports in Internal Medicine, 2016
We report a case of paradoxical deterioration. A male patient diagnosed with pleural tuberculosis, but who was not infected with human immunodeficiency virus (HIV), experienced clinical deterioration 3 weeks after the initiation of anti-tuberculous ...
Luis Corral-Gudino, Alicia Rivas-Lazamares, Ana Gonzalez-Fernandez, Juan Carlos Hernando-Garcia   +3 more
doaj   +1 more source

A Randomized Double‐Blind, Placebo‐Controlled Trial of Artesunate and Curcumin in Patients With Crohn's Disease: A Pilot Study

JGH Open, Volume 9, Issue 7, July 2025.
ABSTRACT Aim Less than half of all patients with Crohn's disease remain in remission with long‐term use of azathioprine. Our aim was to assess the efficacy of Artesunate and Curcumin in maintaining remission in patients with Crohn's disease, who had ongoing evidence of disease activity despite taking azathioprine.
Devinder Kumar, Uday C Ghoshal, Vamika Mansi Saigal, Moni Chaudhary, Shikha Sahu, Vishruti Pandya, Ujjala Ghoshal   +6 more
wiley   +1 more source

Synthesis and Biological Evaluation of 2-(3-Fluoro-4-nitro phenoxy)-N-phenylacetamide Derivatives as Novel Potential Affordable Antitubercular Agents

Molecules, 2012
A novel series of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide compounds were designed, synthesized and in vitro assessed for their antitubercular activities by a microdilution method.
Yu-Quan Wei, Tao Yang, Jian-Zhong Yang, Wei-Yi Pi, Ying-Hong Yang, You-Fu Luo, Yong Deng, Yan-Ni Lin, Wei Ang   +8 more
doaj   +1 more source

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
wiley   +1 more source

Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis [PDF]

, 2011
New drugs active against drug-resistant tuberculosis are urgently needed to extend the range of TB treatment options to cover drug resistant infections.
Aldana, I. (Ignacio), Ancizu, S. (Saioa), Burguete, A. (Asunción), Goldman, R.C. (Robert C.), Jaso, A. (Andrés), Marin, A. (Adoración), Monge, A. (Antonio), Pérez-Silanes, S. (Silvia), Solano, B. (Beatriz), Vicente, E. (Esther), Villar, R. (Raquel), Zarranz, B. (Belén)   +11 more
core  

Bioactives From Brown Algae: Antioxidant, Anti‐Inflammatory, Anticancer, and Antimicrobial Potential

ChemBioEng Reviews, Volume 12, Issue 3, June 2025.
This review explores key bioactives in brown algae and their antioxidant, anti‐inflammatory, anticancer, and antimicrobial properties. Covering studies from 2014 to 2024, it highlights their relevance in pharmaceuticals, nutraceuticals, cosmetics, and foods, while addressing challenges and future directions to unlock their full potential.
Irvin Fonseca‐Barahona, Kaveh Shahbaz, Saeid Baroutian   +2 more
wiley   +1 more source

Novel Metronidazole Conjugates as Antimicrobial Agents

Drug Development Research, Volume 86, Issue 4, June 2025.
ABSTRACT Metronidazole (MTZ) is one of the oldest and still used anti‐infective nitroimidazole group drug. Although it is effective against anaerobic bacteria, protozoa, and parasites in clinical settings, it lacks efficacy against aerobic microorganisms.
Erol Akgün, Melike Demirayak, Leyla Yurttaş, Ülkiye Dudu Gül, Şeref Demirayak   +4 more
wiley   +1 more source

Synthesis of Some Thiosemicarbazone and Oxirane Derivatives as Potent Antitubercular Agents. [PDF]

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
D. H. Purohit, K. H. Popat, P. T. Chovatia, Hitendra S. Joshi   +3 more
openaire   +3 more sources

Metabolism of the Antituberculosis Drug Ethionamide [PDF]

, 2013
Ethionamide (ETH) is an important second-line antituberculosis drug used for the treatment of patients infected with multidrug-resistant Mycobacterium. Although ETH is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated
Helder A Santos, Nuno Vale, Paula Gomes
core   +1 more source