Results 41 to 50 of about 13,713 (167)

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Management of Hepatic Granulomatous Tuberculosis After BCG Therapy for Bladder Cancer

Urology Case Reports, 2017
BCG therapy is used as a treatment in bladder cancer. Intravesical administration of Bacillus Calmette-Guérin is used as a treatment method in superficial bladder cancer. While it is commonly effective, some serious side effects may occur.
Mohsen Ayati, Mohammad Reza Nowroozi, Afshin Mortazavi, Solmaz Ohadian Moghadam, Hossein Ghorani   +4 more
doaj   +1 more source

Current Progress in Differentiating Crohn's Disease From Intestinal Tuberculosis

iLABMED, Volume 4, Issue 2, Page 78-90, June 2026.
Currently, there are various methods from different fields used to differentiate Crohn's disease from intestinal tuberculosis (ITB). Endoscopic findings are an important cornerstone. They can be used individually or in combination (models) to demonstrate excellent discriminative ability.
Chuyao Zhang, Xiaoyin Zhang
wiley   +1 more source

Substrate Characterization of Mycobacterial Kinase PknG Revealing PknG‐KARS‐MAPK Phosphorylation Signaling Axis in Host

iMetaMed, Volume 2, Issue 2, June 2026.
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian, Shuyu Xie, Yanqing Tang, Junjie Liang, Wenhan Zhu, Tianqi Liu, Yewen Sun, Yang Yang, Luoxi Zhang, Danfeng Wang, Chuyao Lin, Jinyu Jia, Minjia Tan, Jun‐Yu Xu   +13 more
wiley   +1 more source

Exploring gut microbiota and its predicted functions in pulmonary tuberculosis: A multi-regional study using public 16S datasets.

PLoS ONE
BackgroundPulmonary tuberculosis, caused by the bacillus Mycobacterium tuberculosis, remains a major global health challenge, particularly in developing countries.
Tejaswini Baral, Anwesh Maile, Nagarajaram Hampapathalu Adimurthy, Kavitha Saravu, Chandrashekar Udyavara Kudru, Jitendra Singh, Chiranjay Mukhopadhyay, Mahadev Rao, Mohan K Manu, Sonal Sekhar Miraj   +9 more
doaj   +1 more source

Management of Hepatotoxicity and Utilization of Antitubercular Drugs in Chronic Liver Disease: A Narrative Review

Journal of Nepal Medical Association
The World Health Organization’s “End TB strategy” envisions a world free of tuberculosis (TB), emphasizing early diagnosis, effective treatment, and prevention.
Pratap Sagar Tiwari, Pukar Thapa
doaj   +1 more source

Isolated tubercular abscess in immunocompetent children: A systematic review of case reports

Indian Pediatrics Case Reports, 2023
Background: Tuberculosis (TB) is a common disease, especially in low-income countries, with a varied clinical spectrum involving multiple organs. Although liver abscess can be seen in 70% of patients with miliary tuberculosis, isolated tuberculous liver ...
Rajkumar Kundavaram, Sourabh Singh, Amber Kumar, Shikha Malik, Girish Chandra Bhatt   +4 more
doaj   +1 more source

Cell Envelope Remodeling and Lipid Metabolism Coordinate Extracellular Vesicle Output in Mycobacterium Tuberculosis

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading global cause of death due to the pathogen's highly adaptive physiology and its ability to manipulate host immunity. Despite extensive study, our understanding of Mtb biology during infection remains incomplete, limiting the development of new diagnostics ...
José L. Serrano‐Mestre, Laura Lerma, Lucía Vázquez‐Iniesta, Vivian C. Salgueiro‐Toledo, Ainhoa Palacios, Sogol Alebouyeh, Andrea Doddi, Felix Elortza, Mikel Azkargorta, Leticia Sampedro, Estibaliz Atondo, Miguel Ángel Pacual‐Itoiz, Oren Mayer, Torin Westwood, William R. Jacobs Jr, Rafael Prados‐Rosales   +15 more
wiley   +1 more source

Secondary hemophagocytic lymphohistiocytosis and isolated cerebellar ataxia due to disseminated tuberculosis with challenging management: A rare case report

Indian Journal of Allergy Asthma and Immunology
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder which occurs due to excessive immune response and high cytokine levels leading to tissue damage and organ failure. HLH can be primary and secondary.
Rahul Kumar Gupta, Sammi Pundir, Mansi Kala, Avriti Baveja, Pranshul Rawat, Anuradha Khandelwal   +5 more
doaj   +1 more source

Study of impact of antitubercular therapy on quality of life

Indian Journal of Medical Sciences, 2012
Many aspects of tuberculosis (TB) and its treatment can compromise patients' quality of life (QOL). Treatment of active TB requires prolonged therapy with multiple drugs that can lead to adverse reactions. There is considerable social stigma associated with TB, leaving the individual feeling shunned and isolated.
Abhishek, Balgude, Smita, Sontakke
openaire   +2 more sources