Results 61 to 70 of about 13,713 (167)

Penile Papulonecrotic Tuberculide

Indian Journal of Dermatology, 2003
A 38 year old male presented with an eight year history of recurrent popular eruptions followed by ulceration and scarring on glans penis. Based on histopathological examination, a diagnosis of papulonecrotic tuberculide was made.
Rana Sandeep, D′ Souza Paschal, Khare Ashok Kumar, Meena Ram Singh, Meherda Ashok, Purohit Sanjay, Nuwal Paras   +6 more
doaj  

Antitubercular drug-induced lichen planus: A case study with a mini literature review

Journal of Family Medicine and Primary Care
Introduction: Drug-induced lichen planus is a cutaneous adverse effect that manifests as a systemic eruption of flat-topped, erythematous, or violaceous papules resembling lichen planus on the trunk and extremities.
Sanjana C Shanmukhappa, Winny John, Vineeta Kevalramani, Srivatsa Lokeshwaran, Shireen Furtado, Mahesh Nosenoor   +5 more
doaj   +1 more source

Interpretable machine learning enables early and accurate detection of drug‐induced liver injury: A multicenter study with real‐world clinical translation

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This study develops an interpretable gradient‐boosting model that accurately identifies drug‐induced liver injury (DILI) using routine laboratory data. The model explains key clinical features through SHapley Additive exPlanations analysis and detects DILI earlier than expert evaluation, offering a transparent and practical tool for precision ...
Jingyi Ling, Shian Zhang, Jun Lin, Zhengju Xu, Runcheng Xu, Qian Lv, Kaixiang Zhang, Sheng Liu, Jie Guo, Cheng Hua, Yin Jia, Xiaoyu Xu, Kun Qian, Shanrong Liu   +13 more
wiley   +1 more source

Rifampicin-induced Secondary Hyperparathyroidism in a Case of Isoniazid Monoresistant Pulmonary Tuberculosis

The Journal of Association of Chest Physicians
Antitubercular drug (ATD)-induced hypovitaminosis D3 and secondary hyperparathyroidism are less reported phenomena compared to other antitubercular therapy–induced adverse events.
Indra Kishor Saha, Rohan Malakar, Anubha Biswas, Saptarshi Goswami   +3 more
doaj   +1 more source

Randomized, Placebo‐Controlled, First‐in‐Human Study of the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Oral Doses of Novel Antitubercular Drug Candidate, GSK2556286, in Healthy Adults

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract This first‐in‐human study (ClinicalTrials.gov identifier: NCT04472897) evaluated the safety, tolerability, pharmacokinetics, and food effect of single ascending and repeat oral doses of GSK2556286 (GSK286), a novel antitubercular drug candidate with efficacy in animal models of tuberculosis.
Emma Ilsley, Edward Banham‐Hall, Tetyana Chaychenko, Katerina Chinenyeze, Gareth Maher‐Edwards, Catherine Muya, Katie Rolfe, Raman Sharma, Simon Tiberi, David Barros‐Aguirre   +9 more
wiley   +1 more source

Primary tuberculoma of the liver: a case report and literature review

The Pan African Medical Journal, 2014
We report the case of an immunocompetent patient with an isolated tuberculoma of the liver, which was diagnosed by percutaneous US-guided liver biopsy. The patient received an antitubercular therapy, and there has been no relapse to date.
Ghizlane Kharrasse, Mehdi Soufi, Hayat Berekhli, Hidaya Intissar, Mohammed Bouziane, Zahi Ismaili   +5 more
doaj   +1 more source

Gaining insights into MmpL3: combining structural and computational approaches to unlock transport and inhibitor‐binding mechanisms

Acta Crystallographica Section D, Volume 82, Issue 5, Page 550-570, May 2026.
This study investigates the mycobacterial membrane protein MmpL3, a key target for new antituberculosis drugs, by combining high‐resolution crystallography and computational simulations. It reveals how the inhibitor UPAR‐1109 binds to MmpL3, providing detailed insights into the function and flexibility of the protein and supporting the rational design ...
Satoshi Murakami, Domenico Marson, Eiki Yamashita, Bruno Broshka, Ui Okada, Maho Aoki, Giannamaria Annunziato, Erik Laurini, Emanuele Carosati, Marco Pieroni   +9 more
wiley   +1 more source

Tuberculoma of the Tongue Presenting as Hemimacroglossia

Case Reports in Medicine, 2012
The underdiagnosis of extrapulmonary tuberculosis lesions, along with an emerging global resistance to antitubercular drugs, warrants an increased awareness of the involvement of Mycobacterium tuberculosis in atypical lesions of oral cavity.
S. P. S. Yadav, Arpit Agrawal, J. S. Gulia, Sunita Singh, Arsh Gupta, Vineet Panchal   +5 more
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

CBr4‐Mediated Metal‐Free Sulfonamide Synthesis: A Comparative Study Under Batch, Continuous‐Flow and Ultrasonic Conditions

Asian Journal of Organic Chemistry, Volume 15, Issue 4, April 2026.
A practical and efficient CBr4‐mediated metal‐free route for sulfonamide synthesis is presented under batch, ultrasonic, and continuous‐flow conditions. The protocol demonstrates excellent substrate scope, reduced reaction times, and mild operating conditions, highlighting a scalable alternative to traditional iodine‐mediated methods in modern ...
Alageswaran Jayaram, Vijay Thavasianandam Seenivasan, Yu‐Ming Liu, Yu‐Chen Lin, Tsz‐Fai Leung, Ching‐Ching Yu, Wei‐Yu Lin   +6 more
wiley   +1 more source