Results 91 to 100 of about 506,874 (259)

Antitumor T cells [PDF]

Nature Methods, 2018
openaire   +3 more sources

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents [PDF]

, 1986
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Cox, O., Elo, Hannu, Kovacic, Peter, Lumme, Paavo, Ryan, Michael D.   +5 more
core   +1 more source

Self‐Cascade Catalytic Reaction–Assisted Apoptosis/Calcicoptosis/Ferroptosis Induction with Microsphere‐Aggregated Hydrogels in Triple‐Negative Breast Cancer Therapy

Advanced Functional Materials, EarlyView.
Hyaluronic acid‐dopamine‐based intra‐crosslinked microsphere including cisplatin (HPC MS) is fabricated by spray‐drying and calcium/iron ions are introduced for interparticle crosslinking. Designed microsphere‐aggregated hydrogel (MAH) system including cisplatin/CaO2/FeSO4 can provide apoptosis/calcicoptosis/ferroptosis‐mediated chemo/cascade ...
ChaeRim Hwang, Yeoung Eun Choi, Song Yi Lee, Mrinmoy Karmakar, Qiaojun Hao, Junmin Lee, Hyun‐Jong Cho   +6 more
wiley   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment [PDF]

, 2014
Ali, Ali, Alnemri, Alshamsan, Anguille, Apetoh, Badie, Bal, Banciu, Becker, Belizaire, Benteyn, Blander, Bonehill, Breckpot, Broderick, Casares, Chang, Chiang, Clowes, Coley, Coulie, Cubillos-Ruiz, de Vries, Demento, Dominguez, Emeagi, Emeagi, Fernandez, Fischer, Fischer, Franklin, Gabrilovich, Giddam, Gooden, Gross, Gunzer, Haen, Hamzah, Harris, Heleen Dewitte, Henri, Hess, Hobbs, Hu, Huang, Huang, Huang, Humphries, Ilyinskii, Ine Lentacker, Ito, Jasani, Johansen, Kadowaki, Karine Breckpot, Kasturi, Kawakami, Kerkar, Kroemer, Kwong, Lake, Lakhani, Larocca, Larsson, Lee, Lee, Leuschner, Li, Li, Li, Liao, Lin, Lu, Luo, Lutz, Ma, Mantovani, Marchini, Matsumura, Matzinger, Matzinger, Melhem, Milicic, Moon, Motz, Mueller, Mukai, Nguyen, Nomura, Nordly, Nowak, Pardoll, Park, Perche, Perrie, Prabhakar, Pradere, Pradhan, Prasad, Puig-Kroger, Qin, Ray, Rein Verbeke, Rizwan, Roy, Roy, Sato, Schlosser, Schouppe, Sharp, She, Shimizu, Shortman, Simpson-Abelson, Singh, Singh, Slutter, Small, Smits, Stano, Stefaan C. De Smedt, Steinman, Su, Tacken, Tang, Tang, Tao, Temming, Thambi, van den Boorn, van der Most, Van Nuffel, Vanderbruggen, Villadangos, Villadangos, Vinogradov, Wang, Warburg, Wayteck, Wei, Wimmers, Wingender, Wong, Wydra, Yanasarn, Yoshizaki, Yu, Zaks, Zeisberger, Zhang, Zhao, Zhou, Zinkernagel   +153 more
core   +2 more sources