Results 91 to 100 of about 531,165 (296)

Increased antitumor efficacy of ginsenoside Rh2 via mixed micelles: in vivo and in vitro evaluation

Drug Delivery, 2020
The aim of this work is to apply Solutol® HS15 and TPGS to prepare self-assembled micelles loading with ginsenoside Rh2 to increase the solubility of ginsenoside Rh2, hence, improving the antitumor efficacy.
Xiaojing Xia, Jin Tao, Zhuwa Ji, Chencheng Long, Ying Hu, Zhiying Zhao   +5 more
doaj   +1 more source

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

Nature Communications, 2017
Gram-negative bacteria actively secrete outer membrane vesicles, spherical nano-meter-sized proteolipids enriched with outer membrane proteins, to the surroundings.
O. Y. Kim, H. T. Park, N. Dinh, S. Choi, Jaewook Lee, J. Kim, Seung-Woo Lee, Y. Gho   +7 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs

Nature Immunology, 2023
Tao Wang, Jinjing Zhang, Yanling Wang, Ying Li, Lu Wang, Yang Yu, Yushi Yao   +6 more
semanticscholar   +1 more source

A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects

Nature Medicine, 2017
The adoptive transfer of T cells engineered with a chimeric antigen receptor (CAR) (hereafter referred to as CAR-T cells) specific for the B lymphocyte antigen CD19 has shown impressive clinical responses in patients with refractory B cell malignancies ...
Yuki Kagoya, Shinya Tanaka, Tingxi Guo, M. Anczurowski, Chung-Hsi Wang, Kayoko Saso, M. Butler, M. Minden, N. Hirano   +8 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A natural PKM2 targeting agent as a potential drug for breast cancer treatment

Clinical and Translational Medicine, 2023
Xin‐Yue Shang, Yu‐Jue Wang, Zi‐Lin Hou, Xin‐Ye Wang, Hao Zhang, Chen‐Yu Yang, Ji‐Chong Li, Xiao‐Xiao Huang, Shao‐Jiang Song, Guo‐Dong Yao   +9 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

Cell Death and Disease, 2018
It is now well established that cancer cells co-exist within a complex environment with stromal cells and depend for their growth and dissemination on tight and plastic interactions with components of the tumor microenvironment (TME). Cancer cells incite
Marco B. E. Schaaf, Abhishek D Garg, P. Agostinis   +2 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source