Results 41 to 50 of about 531,165 (296)

Cytochalasin H enhances sensitivity to gefitinib in non-small-cell lung cancer cells through inhibiting EGFR activation and PD-L1 expression

Scientific Reports
In our previous study, we have isolated cytochalasin H (CyH) from endophytic fungus derived from mangrove plant and found that CyH inhibited the proliferation of non-small cell lung cancer (NSCLC) cells.
Guihong Zhang, Jiao Liu, Sanzhong Li, Tianyu Wang, Li Chen, Huan Li, Qingkai Ding, Xiangyong Li, Shaoping Zhu, Xudong Tang   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Probiotics as multifaceted oral vaccines against colon cancer: A review

Frontiers in Immunology, 2022
Probiotics are known as the live microorganisms that, upon adequate administration, elicit a health beneficial response inside the host. The probiotics are known as immunomodulators and exhibit anti-tumor properties.
Shubhi Singh, Manisha Singh, Smriti Gaur
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Synergistic Anticancer Activity of Fucoidan from Lessonia trabeculata Combined with Chemotherapeutic Agents in 4T1 Breast Spheroids

Marine Drugs
Triple-negative breast cancer (TNBC) is known for being aggressive and potentially resistant to chemotherapy. This means that new ways to improve cancer treatments are a priority.
Rosa María Condori Macuri, Libertad Alzamora-Gonzales, Erasmo Honorio Colona-Vallejos, Raisa Teresa Cruz Riquelme, Laura Inés Pecho Chávez, Jherson Oscar Cisneros Gutierrez, Victor Alonso Montejo Anlas   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Fucoidan from Lessonia trabeculata Induces Apoptosis through Caspase Dependent and Caspase-Independent Activation in 4T1 Breast Adenocarcinoma In Vitro

Marine Drugs
Experiments conducted on triple-negative breast cancer have shown that fucoidan from Lessonia trabeculata (FLt) exhibits cytotoxic and antitumor properties.
Raisa Teresa Cruz Riquelme, Erasmo Honorio Colona-Vallejos, Libertad Alzamora-Gonzales, Rosa María Condori Macuri   +3 more
doaj   +1 more source

Discovery of Novel c-Met Inhibitors Bearing a 3-Carboxyl Piperidin-2-one Scaffold

Molecules, 2014
A series of compounds containing a novel 3-carboxypiperidin-2-one scaffold based on the lead structure BMS-777607 were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against MKN45 cancer cell lines.
Wei Zhang, Jing Ai, Dakuo Shi, Xia Peng, Yinchun Ji, Jian Liu, Meiyu Geng, Yingxia Li   +7 more
doaj   +1 more source

In-vitro evaluation of immunomodulatory activity of sulphation-modified total ginsenosides derivative-3

Frontiers in Veterinary Science, 2023
BackgroundGinseng has been used in biomedicine to prevent and treat decreased physical and mental capacities. Total ginsenosides (TG) from ginseng root which have antitumor and immune-enhancing properties, are the principal active components of Panax ...
Zhiting Guo, Zhiting Guo, Ling Wang, Ling Wang, Shahbaz Ul Haq, Shahbaz Ul Haq, Lu Wang, Wenzhu Guo, Wenzhu Guo, Yongjiang Luo, Yongjiang Luo, Nabeel Ijaz   +11 more
doaj   +1 more source

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

Nature Medicine, 2019
B-cell lymphoma extra large (BCL-XL) is a well-validated cancer target. However, the on-target and dose-limiting thrombocytopenia limits the use of BCL-XL inhibitors, such as ABT263, as safe and effective anticancer agents.
Sajid Khan, Xuan Zhang, D. Lv, Qi Zhang, Yonghan He, Peiyi Zhang, Xingui Liu, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, J. Pei, Weizhou Zhang, Abhisheak Sharma, C. McCurdy, Vinitha M Kuruvilla, Natalia Baran, A. Ferrando, Yong-Mi Kim, A. Rogojina, P. Houghton, Guangcun Huang, R. Hromas, M. Konopleva, Guangrong Zheng, Daohong Zhou   +24 more
semanticscholar   +1 more source