Results 81 to 90 of about 840,802 (388)

Tubeimoside-1: A review of its antitumor effects, pharmacokinetics, toxicity, and targeting preparations

Frontiers in Pharmacology, 2022
Tubeimoside-1 (TBMS-1), a natural triterpenoid saponin found in traditional Chinese herbal medicine Bolbostemmatis Rhizoma, is present in numerous Chinese medicine preparations.
Chang-Lin Wang, Chang-Lin Wang, Ming-Zhou Gao, Ming-Zhou Gao, Dong-Mei Gao, Dong-Mei Gao, Ying-Hui Guo, Ying-Hui Guo, Zhan Gao, Zhan Gao, Xiang-Ju Gao, Xiang-Ju Gao, Jie-Qiong Wang, Jie-Qiong Wang, Ming-Qi Qiao, Ming-Qi Qiao   +15 more
doaj   +1 more source

Polyfunctional Melan-A-specific tumor-reactive CD8+ T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS [PDF]

, 2016
The identification of activation pathways linked to anti-tumor T-cell polyfunctionality in long surviving patients is of great relevance in the new era of immunotherapy.
Belinda, Palermobc, Cosmo Di, Donnac, GISMONDI, Angela, Isabella, Sperdutid, Ornella, Franzesea, SANTONI, Angela, STABILE, MARIA HELENA, Virginia, Ferraresie   +7 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Utilizing non-histological serological markers in the prediction of recurrence and metastasis in head and neck melanoma

Journal of Ophthalmology
There is a need for the development of additional prognostic melanoma (e.g., head and neck melanoma) biomarkers to stratify melanoma patients and reliably identify high-risk subgroups with the aim of providing effective personalized therapy ...
L. O. Kovtun
doaj   +1 more source

Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain

Frontiers in Microbiology, 2021
Actinobacteria are the main producers of bioactive natural products essential for human health. Although their diversity in the atmosphere remains largely unexplored, using a multidisciplinary approach, we studied here 27 antibiotic producing ...
Aida Sarmiento-Vizcaíno, Aida Sarmiento-Vizcaíno, Aida Sarmiento-Vizcaíno, Jesús Martín, Fernando Reyes, Luis A. García, Gloria Blanco, Gloria Blanco, Gloria Blanco   +8 more
doaj   +1 more source

Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort. [PDF]

, 2016
Purpose Treatment with pembrolizumab, an anti-programmed death-1 antibody, at 10 mg/kg administered once every 2 weeks, displayed durable antitumor activity in programmed death-ligand 1 (PD-L1) -positive recurrent and/or metastatic (R/M) head and neck ...
Berger, Raanan, Burtness, Barbara, Cheng, Jonathan D, Chow, Laura QM, Chung, Hyun Cheol, Dolled-Filhart, Marisa, Eder, Joseph Paul, Geva, Ravit, Gupta, Shilpa, Haddad, Robert, Kang, Hyunseok, Keam, Bhumsuk, Lee, Se-Hoon, Lin, Chia-Chi, Mahipal, Amit, Mehra, Ranee, Meister, Amy, Muro, Kei, Pathiraja, Kumudu, Seiwert, Tanguy Y, Tahara, Makoto, Weiss, Jared   +21 more
core   +2 more sources

Itraconazole Exerts Its Antitumor Effect in Esophageal Cancer By Suppressing the HER2/AKT Signaling Pathway [PDF]

, 2021
Wei Zhang, Ankur S. Bhagwath, Zeeshan Ramzan, Taylor Williams, Indhumathy Subramaniyan, Vindhya Edpuganti, Raja Reddy Kallem, Kerry B. Dunbar, Peiguo Ding, Ke Gong, Samuel Geurkink, Muhammad Shaalan Beg, James Kim, Qiuyang Zhang, Amyn A. Habib, Sung Hee Choi, Ritu Lapsiwala, Gayathri Bhagwath, Jonathan E. Dowell, Shelby D. Melton, Chunfa Jie, William C. Putnam, Thai Pham, David H. Wang   +23 more
openalex   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Toxicity, physiological response, and biosorption mechanism of Dunaliella salina to copper, lead, and cadmium

Frontiers in Microbiology
BackgroundHeavy metal pollution has become a global problem, which urgently needed to be solved owing to its severe threat to water ecosystems and human health.
Mingze Gao, Mingze Gao, Na Ling, Na Ling, Haiyan Tian, Haiyan Tian, Chunqiu Guo, Chunqiu Guo, Qiyao Wang   +8 more
doaj   +1 more source

Flubendazole Elicits Antitumor Effects by Inhibiting STAT3 and Activating Autophagy in Non-small Cell Lung Cancer

Frontiers in Cell and Developmental Biology, 2021
Non-small cell lung carcinoma (NSCLC) is a major neoplastic disease with a high mortality worldwide; however, effective treatment of this disease remains a challenge.
Xiaona Xie, Xueding Cai, Yemeng Tang, Chunhui Jiang, Chunhui Jiang, Feng Zhou, Lehe Yang, Zhiguo Liu, Zhiguo Liu, Liangxing Wang, Haiyang Zhao, Chengguang Zhao, Chengguang Zhao, Xiaoying Huang   +13 more
doaj   +1 more source