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Objecfive evaluation of antitussive agents

Clinical Pharmacology and Therapeutics, 1965
Subjective evaluation of antitussives is unreliable. In the search for an ideal procedure for evaluation, several methods have been developed which use bronchial irritants for artificial cough production in selected subjects. The currently popular citric acid and the acetylcholine methods with healthy volunteers were re‐evaluated and in our hands were ...
Patrick D Lester, H Sevelius
exaly   +3 more sources

TRPV1 Antagonists as Potential Antitussive Agents

Lung, 2007
Cough is an important defensive pulmonary reflex that removes irritants, fluids, or foreign materials from the airways. However, when cough is exceptionally intense or when it is chronic and/or nonproductive it may require pharmacologic suppression. For many patients, antitussive therapies consist of OTC products with inconsequential efficacies. On the
Robbie L Mcleod   +2 more
exaly   +3 more sources

Evaluation of Antitussive Agents in Man

Pulmonary Pharmacology, 1996
Methodology to evaluate the efficacy of antitussive drugs rely largely on subjective methods and cough counts. There are few studies in cough due to natural disease especially using objective techniques. This paper presents data from a series of randomized, double blind, placebo controlled clinical trials in cough due to both chronic bronchopulmonary ...
L, Parvez   +4 more
exaly   +3 more sources

Efficacy and tolerability of glaucine as an antitussive agent

Current Medical Research and Opinion, 1984
One hundred and thirty out-patients, affected by acute and chronic cough caused by upper respiratory tract inflammation, took part in two clinical studies aimed at evaluating the efficacy and tolerability of glaucine , a new antitussive agent. The first study involved 90 patients in a double-blind comparative trial of glaucine and codeine: both ...
H Gastpar
exaly   +3 more sources

Studies on the potency of various antitussive agents

Agents and Actions, 1977
Several antitussive agents were assessed for their cough-suppressant activity. Cough responses were obtained by electrically stimulating the lower brainstem, in cats lightly anesthetized with sodium pentobarbital or in unanesthetized midcollicular decerebrate preparations. Cough sounds were recorded with the aid of a microphone.
S C Wang
exaly   +3 more sources

Antitussive agents and their sites of action

Trends in Pharmacological Sciences, 1980
Y Kase
exaly   +2 more sources

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