Results 51 to 60 of about 4,943 (178)

Inflammation induced by snake venoms optimizes envenomation

The Journal of Physiology, Volume 604, Issue 14, Page 5831-5852, 15 July 2026.
Abstract figure legend Schematic illustrating mechanisms underlying direct vascular absorption and subsequent movement of venom toxins into the tissues consequent to snakebite. A, snakebite into prey deposits venom toxins into the tissue interstitium, with the venom then causing acute inflammation primarily in venules.
Dirk F. van Helden, Neil Spratt, Peter J. Dosen, Sally A. McFadden, John Holdsworth, Daniel J Beard, Kirsten Coupland, Phillip Jobling, Todd A. Hardy, Derek R. Laver   +9 more
wiley   +1 more source

A Century of Antivenom

Collegium antropologicum, 2011
Because it primarily affects the poor in undeveloped parts of the world where medical care is often inadequate and insufficient, envenomation is considered a neglected public health issue, despite the existence of antivenom therapy for more than a century. This article provides an overview of the epidemiological situation for important venomous animals,
Lovreček, Dijana, Tomić, Siniša
openaire   +3 more sources

Enhancing the Bothropic Antivenom through a Reverse Antivenomics Approach

Journal of Proteome Research
Antivenoms are the only effective treatment for snakebite envenomation and have saved countless lives over more than a century. Despite their value, antivenoms present risks of adverse reactions. Current formulations contain a fraction of nonspecific antibodies and serum proteins.
Tassia Chiarelli, Jackelinne Y. Hayashi, Nathalia da Costa Galizio, Fernanda M. S. Casimiro, Ricardo Torquato, Aparecida S. Tanaka, Karen de Morais-Zani, Anita M. Tanaka-Azevedo, Alexandre K. Tashima   +8 more
openaire   +2 more sources

Analysis of Two New Flavonoid Glycosides From Zanha golungensis Hiern With COX Inhibition Activity: Structural Elucidation, DFT Calculations, In Vitro and Molecular Docking Assessment

Analytical Science Advances, Volume 7, Issue 1, June 2026.
Zanha golungensis contains phenolic compounds amongst which are two previously undescribed flavonoid glycosides as shown in this study. The constituents of this plant exhibit anti‐inflammatory activity by inhibiting cyclooxygenases (COX‐1 and COX‐2).
Jean Zeuikena, Romeo Toko Feunaing, Alfred Ngenge Tamfu, Abel Joel Yaya Gbaweng, Celine Henoumont, Sophie Laurent, El Hassane Anouar, Emmanuel Talla   +7 more
wiley   +1 more source

Analysis of factors influencing skin sensitivity test results of antivenom and its potential correlation with allergic reactions: a retrospective cohort study

Frontiers in Allergy
BackgroundSnakebite remains a persistent public health concern, whether skin sensitivity testing for antivenom should be performed remains a subject of debate.
Haoyu Wang, Haoyu Wang, Weiwei Qian, Shuyun Xu, Shuyun Xu   +4 more
doaj   +1 more source

Management of scorpion envenoming: a systematic review and meta-analysis of controlled clinical trials

Systematic Reviews, 2017
Background Scorpion stings cause an estimated 3000 deaths per annum worldwide. We conducted a systematic review of all controlled clinical trials related to scorpion sting management.
Chaturaka Rodrigo, Ariaranee Gnanathasan
doaj   +1 more source

Dose and time dependence of box jellyfish antivenom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2014
Background The effectiveness of the currently available box jellyfish (Chironex fleckeri) antivenom has been subject of debate for many years. To assess whether the box jellyfish antivenom has the ability to attenuate venom-induced damage at cellular ...
Athena Andreosso, Michael J Smout, Jamie E Seymour   +2 more
doaj   +1 more source

Third Generation Antivenomics: Pushing the Limits of the In Vitro Preclinical Assessment of Antivenoms [PDF]

Toxins, 2017
Second generation antivenomics is a translational venomics approach designed to complement in vivo preclinical neutralization assays. It provides qualitative and quantitative information on the set of homologous and heterologous venom proteins presenting antivenom-recognized epitopes and those exhibiting impaired immunoreactivity.
Davinia Pla, Yania Rodríguez, Juan Calvete   +2 more
openaire   +4 more sources

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

Guidelines for Essential Trauma Care: Second Edition (2026)

World Journal of Surgery, Volume 50, Issue 6, Page 1409-1450, June 2026.
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock, Timothy C. Hardcastle, Christine Gaarder, Amit Gupta, Adam Gyedu, Manjul Joshipura, Elmin Steyn, on behalf of the Essential Trauma Care revision author group, Valencia Adjei, Roger Alcock, Vanda Amado, Michael Boampong, Sanjeev Booi, Petra Brysiewicz, Corazon Cabanilla‐Manuntag, Cristiane de Alencar Domingues, Ghada Elhadari, Ranjith Nanda Ellawala, Sarnai Erdene, Ama Akoma Essuman, Jorge Esteban Foianini, Filippo Gatti, Armando Garcia Guererra, Greg Hynes, Adil Haider, Sandy Ingless, Balavenkata Jagannathan, Helen Jowett, Knut Magne Kolstadbråten, Sonja Krofak, Aireen Patricia Madrid, Tina Tomić Mahečić, Claude Martin, Daniel Ntogwrachu, Bisola Onajin‐Obembe, Nhobojit Roy, Andres Rubiano, Niisoja Mensah Torto, Ben Wachira, Meg Walmsley, Torben Wisborg, Elma Wong   +41 more
wiley   +1 more source