Results 111 to 120 of about 928,338 (389)

In-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells

Scientific Reports
Three years after SARS-CoV-2 emerged as a global infectious threat, the virus has become endemic. The neurological complications such as depression, anxiety, and other CNS complications after COVID-19 disease are increasing.
Sean N. Avedissian, Johid R. Malik, Anthony T. Podany, Michael Neely, Nathaniel J. Rhodes, Kimberly K. Scarsi, Marc H. Scheetz, Michael J. Duryee, Ukamaka O. Modebelu, Timothy M. Mykris, Lee C. Winchester, Siddappa N. Byrareddy, Courtney V. Fletcher   +12 more
doaj   +1 more source

Cochrane acute respiratory infections group's stakeholder engagement project identified systematic review priority areas [PDF]

, 2018
Objective: Cochrane acute respiratory infections (ARIs) group conducts systematic reviews of the evidence for treatment and prevention of ARIs. We report the results of a prioritization project, aiming to identify highest priority systematic review ...
Clark, Justin, Del Mar, Chris, Dooley, Liz, Jones, Ann, Jones, Mark, Scott, Anna Mae   +5 more
core   +1 more source

ISG15 in antiviral immunity and beyond

Nature Reviews Microbiology, 2018
The host response to viral infection includes the induction of type I interferons and the subsequent upregulation of hundreds of interferon-stimulated genes.
Yi-Chieh Perng, D. Lenschow
semanticscholar   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Invasive Obstetric Procedures and Cesarean Sections in Women With Known Herpes Simplex Virus Status During Pregnancy. [PDF]

, 2017
BackgroundNeonatal herpes is a potentially devastating infection that results from acquisition of herpes simplex virus (HSV) type 1 or 2 from the maternal genital tract at the time of vaginal delivery.
Drolette, Linda, Gardella, Carolyn, Laschansky, Ellen, Magaret, Amalia S, Moss, Nicholas J, Selke, Stacey, Stankiewicz Karita, Helen C, Wald, Anna   +7 more
core   +1 more source

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential

ACS Infectious Diseases, 2020
The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various ...
Jimin Xu, P. Shi, Hongmin Li, Jia Zhou
semanticscholar   +1 more source

Antiviral Treatments

Clinics in Chest Medicine, 2017
Most viral respiratory tract infections are caused by classic respiratory viruses, including influenza, respiratory syncytial virus, human metapneumovirus, parainfluenza, rhinovirus, and adenovirus, whereas other viruses, such as herpes simplex, cytomegalovirus, and measles virus, can opportunistically affect the respiratory tract.
openaire   +2 more sources

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

Advanced Healthcare Materials, EarlyView.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer, Lea Skrzypczyk, Sabrina Wohlfart, Bryan Calder Ackermann, Ludwig Geisweid, Simon William Pohl, Margarita Karaivanova, Jonathan Herth, Victor Aristide Augustin, Alexander Studier‐Fischer, Tina Sackmann, Leon Kaulen, Anna Steyer, Walter Mier, David H Steel, Kanmin Xue, Gerd Uwe Auffarth, Philipp Uhl   +17 more
wiley   +1 more source

Bacteroides thetaiotaomicron ameliorates mouse hepatic steatosis through regulating gut microbial composition, gut-liver folate and unsaturated fatty acids metabolism

Gut Microbes
Gut microbiota plays an essential role in the progression of nonalcoholic fatty liver disease (NAFLD), making the gut-liver axis a potential therapeutic strategy.
Hu Li, Xue-Kai Wang, Mei Tang, Lei Lei, Jian-Rui Li, Han Sun, Jing Jiang, Biao Dong, Hong-Ying Li, Jian-Dong Jiang, Zong-Gen Peng   +10 more
doaj   +1 more source

Coxsackievirus A16 utilizes cell surface heparan sulfate glycosaminoglycans as its attachment receptor

Emerging Microbes and Infections, 2017
Coxsackievirus A16 (CVA16) is one of the major pathogens responsible for hand, foot and mouth disease, which affects more than two million children in the Asian-Pacific region annually.
Xueyang Zhang, Jinping Shi, Xiaohua Ye, Zhiqiang Ku, Chao Zhang, Qingwei Liu, Zhong Huang   +6 more
doaj   +1 more source