Results 1 to 10 of about 10,450,245 (405)

The Antiviral Activity of Trifluoromethylthiolane Derivatives [PDF]

Chemistry Proceedings, 2022
The search for new antiviral agents is an important task today. The aim of this study was to elucidate the impact of trifluoromethylthiolane derivatives on herpetic and adenoviral infections.
Liubov Artiukh, Olga Povnitsa, Yuriy Shermolovich, Sergiy Siry, Svitlana Zahorodnia   +4 more
doaj   +2 more sources

Reactive oxygen species promotion drives auranofin's antiviral activity against hepatitis E virus. [PDF]

J Virol
Hepatitis E virus (HEV) causes roughly 20 million yearly global infections and is associated with chronic hepatitis, neurological sequelae, and pregnancy-related adverse outcomes that require antiviral intervention.
Tiller K, Williams ST, Wang B, Tian D, Meng X-J, Weger-Lucarelli J.   +5 more
europepmc   +2 more sources

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity [PDF]

bioRxiv, 2020
Antiviral therapy is urgently needed to combat the coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Markus Hoffmann, Heike Hofmann-Winkler, Joan C. Smith, Nadine Krüger, Lambert K. Sørensen, Ole S. Søgaard, Jørgen Bo Hasselstrøm, Michael Winkler, Tim Hempel, Lluı́s Raich, Simon Olsson, Takashi Yamazoe, Katsura Yamatsuta, Hirotaka Mizuno, Stephan Ludwig, Frank Noé, Jason M. Sheltzer, Mads Kjølby, Stefan Pöhlmann   +18 more
openalex   +2 more sources

Broad-spectrum antiviral activity of ebselen. [PDF]

Sci Rep
Broad-spectrum antivirals are essential for pandemic preparedness, helping reduce mortality and mitigate social disruption. Ebselen, a synthetic organoselenium compound, is under investigation for treating various conditions, including viral infections ...
Jitobaom K, Boonyuen U, Boonarkart C, Sirihongthong T, Auewarakul P.   +4 more
europepmc   +2 more sources

Phosphorylation of Shiftless by casein kinase 1 δ/ε is required for its antiviral activity. [PDF]

J Virol
Shiftless (SHFL) is a host antiviral factor that inhibits the viral −1 programmed ribosomal frameshifting (−1PRF). How the antiviral activity of SHFL is regulated is not known. Here, we report that the phosphorylation of SHFL by the casein kinase 1 delta
Wang Y, Fu S, Wang X, Gao G.
europepmc   +2 more sources

SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model

Science, 2021
Targeting the SARS-CoV-2 main protease Vaccines are an important tool in the fight against COVID-19, but developing antiviral drugs is also a high priority, especially with the rise of variants that may partially evade vaccines.
J. Qiao, Yue-Shan Li, R. Zeng, Feng-Liang Liu, R. Luo, Chong Huang, Yi-Fei Wang, Jie Zhang, B. Quan, Chenjian Shen, X. Mao, Xinlei Liu, Weining Sun, Wei Yang, X. Ni, Kai Wang, Ling Xu, Zilei Duan, Qing-Cui Zou, Hai-Lin Zhang, Wang Qu, Yang-Hao-Peng Long, Ming-hua Li, Rui Yang, Xiaolong Liu, Jing You, Yangli Zhou, R. Yao, Wen-Pei Li, Jingming Liu, Pei Chen, Yang Liu, Guifeng Lin, Xin Yang, Jun Zou, Linli Li, Yiguo Hu, G. Lu, Weiming Li, Yuquan Wei, Yong-tang Zheng, Jiankun Lei, Sheng-yong Yang   +42 more
semanticscholar   +1 more source

Molnupiravir and Its Antiviral Activity Against COVID-19

Frontiers in Immunology, 2022
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) constitutes a major worldwide public health threat and economic burden.
L. Tian, Zehan Pang, Maochen Li, Fuxing Lou, X. An, Shaozhou Zhu, Lihua Song, Y. Tong, Huahao Fan, Junfen Fan   +9 more
semanticscholar   +1 more source

The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor

Emerging Microbes and Infections, 2021
Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that lacks effective therapeutic interventions. SARS-CoV-2 infects ACE2-expressing cells and gains cell entry through either direct plasma membrane fusion or endocytosis.
Yanmei Hu, Xiangzhi Meng, Fushun Zhang, Y. Xiang, Jun Wang   +4 more
semanticscholar   +1 more source

The vitamin D receptor agonist EB1089 can exert its antiviral activity independently of the vitamin D receptor.

PLoS ONE, 2023
Vitamin D has been shown to have antiviral activity in a number of different systems. However, few studies have investigated whether the antiviral activity is exerted through the vitamin D receptor (VDR).
Janejira Jaratsittisin, Wannapa Sornjai, Thanathom Chailangkarn, Anan Jongkaewwattana, Duncan R Smith   +4 more
doaj   +1 more source

Antiviral activity of bacterial TIR domains via immune signalling molecules

Nature, 2021
The Toll/interleukin-1 receptor (TIR) domain is a canonical component of animal and plant immune systems1,2. In plants, intracellular pathogen sensing by immune receptors triggers their TIR domains to generate a molecule that is a variant of cyclic ADP ...
G. Ofir, Ehud Herbst, Maya Baroz, Daniel Cohen, A. Millman, Shany Doron, Nitzan Tal, Daniel B. A. Malheiro, S. Malitsky, Gil Amitai, R. Sorek   +10 more
semanticscholar   +1 more source