Results 171 to 180 of about 10,107,736 (396)

Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins

Scientific Reports, 2016
Novel therapeutic options are urgently needed to improve global treatment of virus infections. Herbal products with confirmed clinical safety features are attractive starting material for the identification of new antiviral activities.
Stephanie V. Rebensburg, Markus Helfer, Martha Schneider, H. Koppensteiner, J. Eberle, M. Schindler, L. Gürtler, R. Brack-Werner   +7 more
semanticscholar   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Antiviral Effect Assay of Twenty Five Species of Various Medicinal Plants Families in Iran

Journal of Medicinal Plants, 2007
Background: Medicinal plants have been traditionally used for different kinds of ailments including infectious diseases. There is an increasing need for substances with antiviral activity since the treatment of viral infections with the available ...
SA Ziai, R Hamkar, HR Monavari, Z Norooz-Babaei, L Adibi   +4 more
doaj  

Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus

Communications Medicine
Background Effective antiviral therapy is lacking for most viral infections, and when available, is frequently compromised by the selection of resistance.
Baolong Pan, Simon J. Mountford, Maki Kiso, Danielle E. Anderson, Georgina Papadakis, Kate E. Jarman, Danielle R. Tilmanis, Belinda Maher, Thomas Tran, Jake Shortt, Seiya Yamayoshi, Yoshihiro Kawaoka, Philip E. Thompson, Sam A. Greenall, Nadia Warner   +14 more
doaj   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

TCMD: A High‐Throughput and Rapid Method for Screening Antimicrobial Ingredients from Renewable Bio‐Based Resources

Advanced Science, EarlyView.
This study develops a strategy to screen the active compounds from bio‐mixtures via combining transcriptomic profiling and molecular docking. The proposed method demonstrates 100% correction in three different biobased mixtures and is 3–20 times faster than traditional approaches.
Yongdong Xu, Yueyao Wang, Yongming Chen, Yunxia Wang, Shicheng Zhang, Gang Luo, Fuhao Cui, Taisheng Du, Zhidan Liu   +8 more
wiley   +1 more source

Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B

Advanced Science, EarlyView.
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang, Cong Sun, Chu Xie, Bing‐Zhen Cheng, Zheng‐Zhou Lu, Ge‐Xin Zhao, Sen‐Fang Sui, Mu‐Sheng Zeng, Zheng Liu   +8 more
wiley   +1 more source

Mode of Action of the Antiviral Activity of Amantadine in Tissue Culture [PDF]

, 1965
C. E. Hoffmann, E Neumayer, R. F. Haff, Richard A. Goldsby   +3 more
openalex   +1 more source

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
wiley   +1 more source