Results 21 to 30 of about 10,450,245 (405)

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Clinical Infectious Diseases, 2020
Background The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection.
Xueting Yao, F. Ye, Miao Zhang, Cheng Cui, Baoying Huang, P. Niu, X. Liu, Li Zhao, Erdan Dong, Chunli Song, S. Zhan, R. Lu, Haiyan Li, W. Tan, Dongyang Liu   +14 more
semanticscholar   +1 more source

Antiviral Activity of Lysozyme [PDF]

Nature, 1959
THE biological significance of lysozyme is not yet fully established. Its properties suggest that it has a role in immunism against bacterial infections. Lysozyme also seems to show antiviral activity. Previous observations support this possibility.
R, FERRARI, C, CALLERIO, G, PODIO
openaire   +2 more sources

Antiviral Activity of Carrageenans and Processing Implications

Marine Drugs, 2021
Carrageenan and carrageenan oligosaccharides are red seaweed sulfated carbohydrates with well-known antiviral properties, mainly through the blocking of the viral attachment stage. They also exhibit other interesting biological properties and can be used
Milena Álvarez-Viñas, S. Souto, N. Flórez-Fernández, M. Torres, I. Bandín, H. Domínguez   +5 more
semanticscholar   +1 more source

Antiviral efficacy of nanomaterial-treated textiles in real-life like exposure conditions

Heliyon, 2023
Due to the growing interest towards reducing the number of potentially infectious agents on critical high-touch surfaces, the popularity of antimicrobially and antivirally active surfaces, including textiles, has increased.
Alexandra Nefedova, Kai Rausalu, Eva Zusinaite, Vambola Kisand, Mati Kook, Krisjanis Smits, Alexander Vanetsev, Angela Ivask   +7 more
doaj   +1 more source

Anti–SARS‐CoV‐2 Repurposing Drug Database: Clinical Pharmacology Considerations

CPT: Pharmacometrics & Systems Pharmacology, 2021
A critical step to evaluate the potential in vivo antiviral activity of a drug is to connect the in vivo exposure to its in vitro antiviral activity. The Anti–SARS‐CoV‐2 Repurposing Drug Database is a database that includes both in vitro anti–SARS‐CoV‐2 ...
Xinyuan Zhang, Yuching Yang, Manuela Grimstein, Guansheng Liu, Eliford Kitabi, Jianghong Fan, Ying‐Hong Wang, Justin Earp, James L. Weaver, Hao Zhu, Jiang Liu, Kellie S. Reynolds, Shiew‐Mei Huang, Yaning Wang   +13 more
doaj   +1 more source

Antiviral Activity of Ribosome-Inactivating Proteins

Toxins, 2021
Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades.
Lucía Citores, Rosario Iglesias, José M. Ferreras   +2 more
doaj   +1 more source

Research progress on the antiviral activities of natural products and their derivatives: Structure–activity relationships

Frontiers in Chemistry, 2022
Viruses spread rapidly and are well-adapted to changing environmental events. They can infect the human body readily and trigger fatal diseases. A limited number of drugs are available for specific viral diseases, which can lead to non-efficacy against ...
Yajing Guo, Anna Ma, Xinyan Wang, Chen Yang, Xi Chen, Gen Li, Feng Qiu, Feng Qiu   +7 more
doaj   +1 more source

Antiviral Activity of CD437 Against Mumps Virus

Frontiers in Microbiology, 2021
Many efforts have been dedicated to the discovery of antiviral drug candidates against the mumps virus (MuV); however, no specific drug has yet been approved.
Fumihiro Kato, Yuichiro Nakatsu, Keiko Murano, Aika Wakata, Toru Kubota, Takayuki Hishiki, Toshiyuki Yamaji, Minoru Kidokoro, Minoru Kidokoro, Hiroshi Katoh, Makoto Takeda   +10 more
doaj   +1 more source

Poly(ADP-ribose) potentiates ZAP antiviral activity.

PLoS Pathogens, 2022
Zinc-finger antiviral protein (ZAP), also known as poly(ADP-ribose) polymerase 13 (PARP13), is an antiviral factor that selectively targets viral RNA for degradation.
Guangai Xue, Klaudia Braczyk, Daniel Gonçalves-Carneiro, Daria M Dawidziak, Katarzyna Sanchez, Heley Ong, Yueping Wan, Kaneil K Zadrozny, Barbie K Ganser-Pornillos, Paul D Bieniasz, Owen Pornillos   +10 more
doaj   +1 more source

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The previous lack of consensus around the use of hydroxychloroquine for COVID-19 patients underlines the need to thoroughly assess the in vivo efficacy of drugs against SARS-CoV-2.
Suzanne J. F. Kaptein, Sofie Jacobs, Lana Langendries, Laura Seldeslachts, Sebastiaan ter Horst, L. Liesenborghs, Bart Hens, V. Vergote, E. Heylen, Karine Barthelemy, E. Maas, Carolien de Keyzer, Lindsey Bervoets, Jasper Rymenants, Tina Van Buyten, Xin Zhang, R. Abdelnabi, J. Pang, Rachel J. Williams, H. Thibaut, K. Dallmeier, R. Boudewijns, Jens Wouters, P. Augustijns, N. Verougstraete, C. Cawthorne, J. Breuer, C. Solas, B. Weynand, P. Annaert, I. Spriet, G. Vande Velde, J. Neyts, J. Rocha-Pereira, Leen Delang   +34 more
semanticscholar   +1 more source