Results 21 to 30 of about 10,107,380 (301)

SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model

Science, 2021
Targeting the SARS-CoV-2 main protease Vaccines are an important tool in the fight against COVID-19, but developing antiviral drugs is also a high priority, especially with the rise of variants that may partially evade vaccines.
J. Qiao, Yue-Shan Li, R. Zeng, Feng-Liang Liu, Rong-Hua Luo, Chong Huang, Yi-Fei Wang, Jie Zhang, B. Quan, Chenjian Shen, X. Mao, Xinlei Liu, Weining Sun, Wei Yang, X. Ni, Kai Wang, Ling Xu, Zilei Duan, Qing-Cui Zou, Hai-Lin Zhang, Wang Qu, Yang-Hao-Peng Long, Ming-hua Li, Rui Yang, Xiaolong Liu, Jing You, Yangli Zhou, R. Yao, Wen-Pei Li, Jingming Liu, Pei Chen, Yang Liu, Guifeng Lin, Xin Yang, Jun Zou, Linli Li, Yiguo Hu, G. Lu, Weiming Li, Yuquan Wei, Yong-tang Zheng, Jiankun Lei, Sheng-yong Yang   +42 more
semanticscholar   +1 more source

The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor

Emerging Microbes and Infections, 2021
Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that lacks effective therapeutic interventions. SARS-CoV-2 infects ACE2-expressing cells and gains cell entry through either direct plasma membrane fusion or endocytosis.
Yanmei Hu, Xiangzhi Meng, Fushun Zhang, Y. Xiang, Jun Wang   +4 more
semanticscholar   +1 more source

Antiviral activities of flavonoids

Biomedicine & Pharmacotherapy, 2021
Flavonoids are natural phytochemicals known for their antiviral activity. The flavonoids acts at different stages of viral infection, such as viral entrance, replication and translation of proteins. Viruses cause various diseases such as SARS, Hepatitis, AIDS, Flu, Herpes, etc.
Badshah, Syed Lal, Faisal, Shah, Muhammad, Akhtar, Poulson, Benjamin Gabriel, Emwas, Abdul-Hamid M., Jaremko, Mariusz   +5 more
openaire   +3 more sources

Antiviral activity of bacterial TIR domains via immune signalling molecules

Nature, 2021
The Toll/interleukin-1 receptor (TIR) domain is a canonical component of animal and plant immune systems1,2. In plants, intracellular pathogen sensing by immune receptors triggers their TIR domains to generate a molecule that is a variant of cyclic ADP ...
G. Ofir, Ehud Herbst, Maya Baroz, Daniel Cohen, A. Millman, Shany Doron, Nitzan Tal, Daniel B. A. Malheiro, S. Malitsky, Gil Amitai, R. Sorek   +10 more
semanticscholar   +1 more source

The vitamin D receptor agonist EB1089 can exert its antiviral activity independently of the vitamin D receptor.

PLoS ONE, 2023
Vitamin D has been shown to have antiviral activity in a number of different systems. However, few studies have investigated whether the antiviral activity is exerted through the vitamin D receptor (VDR).
Janejira Jaratsittisin, Wannapa Sornjai, Thanathom Chailangkarn, Anan Jongkaewwattana, Duncan R Smith   +4 more
doaj   +1 more source

Antiviral Activity of Silver, Copper Oxide and Zinc Oxide Nanoparticle Coatings against SARS-CoV-2

Nanomaterials, 2021
SARS-CoV-2 is responsible for several million deaths to date globally, and both fomite transmission from surfaces as well as airborne transmission from aerosols may be largely responsible for the spread of the virus.
Padryk Merkl, Siwen Long, G. McInerney, G. Sotiriou   +3 more
semanticscholar   +1 more source

MxA: a broadly acting effector of interferon-induced human innate immunity

Visualized Cancer Medicine, 2022
The Human MxA protein belongs to the dynamin superfamily of large GTPases and plays a vital role in human immunity against a broad spectrum of viruses. Evasion from MxA restriction accounts for the zoonotic transmission of many pathogenic viruses.
Liao Shuang, Gao Song
doaj   +1 more source

Antiviral Activity Exerted by Natural Products against Human Viruses

Viruses, 2021
Viral infections are responsible for several chronic and acute diseases in both humans and animals. Despite the incredible progress in human medicine, several viral diseases, such as acquired immunodeficiency syndrome, respiratory syndromes, and ...
Maria Musarra-Pizzo, Rosamaria Pennisi, Ichrak Ben-Amor, G. Mandalari, M. Sciortino   +4 more
semanticscholar   +1 more source

Antiviral activity of lambda-carrageenan against influenza viruses and severe acute respiratory syndrome coronavirus 2

Scientific Reports, 2021
Influenza virus and coronavirus, belonging to enveloped RNA viruses, are major causes of human respiratory diseases. The aim of this study was to investigate the broad spectrum antiviral activity of a naturally existing sulfated polysaccharide, lambda ...
Y. Jang, Heegwon Shin, Myoung Kyu Lee, Oh Seung Kwon, J. Shin, Yong-il Kim, Chan Woo Kim, Hye-Ra Lee, Meehyein Kim   +8 more
semanticscholar   +1 more source

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Clinical Infectious Diseases, 2020
Background The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection.
Xueting Yao, F. Ye, Miao Zhang, Cheng Cui, Baoying Huang, P. Niu, X. Liu, Li Zhao, Erdan Dong, Chunli Song, S. Zhan, R. Lu, Haiyan Li, W. Tan, Dongyang Liu   +14 more
semanticscholar   +1 more source