Results 31 to 40 of about 10,223,699 (402)

ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication. [PDF]

, 2019
Cellular antiviral programs encode molecules capable of targeting multiple steps in the virus lifecycle. Zinc-finger antiviral protein (ZAP) is a central and general regulator of antiviral activity that targets pathogen mRNA stability and translation ...
Jurado, Andrea, Law, Lok Man John, Li, Melody MH, MacDonald, Margaret R, Razooky, Brandon S, Rice, Charles M, You, Shihyun   +6 more
core   +2 more sources

The Antiviral Activities of ISG15

Journal of Molecular Biology, 2013
Post-translational protein modification is an important strategy for the regulation of the cell proteome independent of the need for new gene expression. Ubiquitin and ubiquitin-like modifiers mediate the regulation of protein levels, signaling pathways, vesicular trafficking, and many other cellular processes through their covalent conjugation to ...
David J. Morales, Deborah J. Lenschow
openaire   +3 more sources

BX795, a kinase inhibitor, inhibit duck plague virus infection via targeting US3 kinase

Poultry Science, 2023
: Duck plague virus (DPV) is a typical DNA virus of waterfowl, it causes huge economic losses to the duck industry due to the higher mortality and lower egg production.
Yanming Tian, Bin Tian, Mingshu Wang, Dongjie Cai, Anchun Cheng, Wei Zhang, Ying Wu, Qiao Yang, Xuming Ou, Di Sun, Shaqiu Zhang, Sai Mao, XinXin Zhao, Juan Huang, Qun Gao, Dekang Zhu, Renyong Jia, Shun Chen, Mafeng Liu   +18 more
doaj   +1 more source

Multiple effects of silymarin on the hepatitis C virus lifecycle [PDF]

, 2010
Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo.
Bourne, Nigel, Brimacombe, Claire L, Cao, Feng, Graf, Tyler N, Grove, Joe, Kane, Olivia J, Lohmann, Volker, Martinez, Laura E, McKeating, Jane A, Nahmias, Yaakov, Negash, Amina, Oberlies, Nicholas H, Owen, David M, Polyak, Stephen J, Pécheur, Eve-Isabelle, Tavis, John E, Wagoner, Jessica   +16 more
core   +1 more source

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs [PDF]

, 2016
Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication ...
Berre, Stefano, Bracher, Franz, Braun, Peter, Couderc, Thérèsr, Gangneux, Nicolas, Karlas, Alexander, Karo-Astover, Liis, Klemm, Uwe, Lecuit, Marc, Merits, Andres, Meyer, Michael, Meyer, Thomas F., Raftery, Martin, Schönrich, Günther, Varjak, Margus, Weege, Friderike, Wurzlbauer, Anne   +16 more
core   +4 more sources

Glycyrrhizic‐Acid‐Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms

Small, 2020
With the gradual usage of carbon dots (CDs) in the area of antiviral research, attempts have been stepped up to develop new antiviral CDs with high biocompatibility and antiviral effects.
Ting Tong, Hongwei Hu, Junwei Zhou, Shuangfei Deng, Xiaotong Zhang, Wantao Tang, L. Fang, Shaobo Xiao, Jiangong Liang   +8 more
semanticscholar   +1 more source

Antiviral and virucidal activity of sodium deoxyribonucleate and its complex with iron against viruses of different kingdoms and families

Вопросы вирусологии, 2023
Introduction. The urgent problem of modern medicine is the fight against acute respiratory viral infections (ARVI). To combat ARVI, drugs of wide antiviral potency are needed, as well as immunomodulating drugs. Such antiviral and immunomodulatory effects
Dmitry N. Nosik, Lyudmila B. Kalnina, Olga A. Lobach, Marina S. Chataeva, Elena V. Berezhnaya, Marina S. Bochkova, Irina A. Kiseleva, Lyudmila M. Selimova, Nikolai N. Nosik   +8 more
doaj   +1 more source

Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease. [PDF]

, 2018
Viruses are underrepresented as targets in pharmacological screening efforts, given the difficulties of devising suitable cell-based and biochemical assays.
Duggan, Brendan M, Emwas, Abdul-Hamid, Gerwick, William H, Kharbatia, Najeh, Kremb, Stephan, O'Rourke, Aubrie, Raji, Misjudeen, Sioud, Salim, Voolstra, Christian R   +8 more
core   +3 more sources

Antiviral Activities of Biflavonoids

Planta Medica, 1999
Biflavonoids such as amentoflavone (1), agathisflavone (2), robustaflavone (3), hinokiflavone (4), volkensiflavone (5), rhusflavanone (7), succedaneflavanone (9), all isolated from Rhus succedanea and Garcinia multiflora, as well as their methyl ethers and acetates, volkensiflavone hexamethyl ether (6), rhusflavanone hexaacetate (8), and ...
Lin, Y. M., Flavin, M. T., Schure, R., Chen, F. C., Sidwell, R., Barnard, Dale L., Huffman, J. H., Kern, E. R.   +7 more
openaire   +3 more sources

Potential antiviral activity of metformin against human Adenovirus-7 [PDF]

Microbes and Infectious Diseases
Background: Human adenovirus 7(HAdV-7) cause acute respiratory tract infections with high morbidity and mortality rates in children and immunocompromised adults. Metformin is a natural oral antihyperglycemic drug, that possesses antiviral activity.
Ibrahim Abdelwahab, Gihan ELBatouti
doaj   +1 more source