Results 71 to 80 of about 10,450,245 (405)

Synthesis of 5-substituted 2'-deoxyuridine-5'-phosphonate analogues and evaluation of their antiviral activity [PDF]

, 2012
A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step procedure including a Wittig reaction and Suzuki-Miyaura coupling.
Balzarini, Jan, Martins, José, Sinnaeve, Davy, Van Calenbergh, Serge, Van Poecke, Sara   +4 more
core   +1 more source

Crucial Role of Selenium in the Virucidal Activity of Benzisoselenazol-3(2H)-ones and Related Diselenides

Molecules, 2010
Various N-substituted benzisoselenazol-3(2H)-ones and their non-selenium-containing analogues have been synthesized and tested against selected viruses (HHV-1, EMCV and VSV) to determine the extent to which selenium plays a role in antiviral activity ...
Jacek Mlochowski, Magdalena Pietka-Ottlik, Piotr Potaczek, Egbert Piasecki   +3 more
doaj   +1 more source

New insights into control of arbovirus replication and spread by insect RNA interference pathways [PDF]

, 2012
Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control ...
Andersson, Angelini, Angelini, Arensburger, Arensburger, Attarzadeh-Yazdi, Berry, Blevins, Brackney, Chung, Cirimotich, Cohen, Czech, Ding, Dubrulle, Fagegaltier, Flynt, Franz, Ghildiyal, Henke, Holt, Hussain, Hussain, Iwasaki, Kaminker, Kawamura, Keene, Kwon, Lagos-Quintana, Li, Lim, Lucchetta, Mendes, Morazzani, Mueller, Myles, Nene, Qi, Rezza, Ruby, Saleh, Sanchez-Vargas, Schwarz, Selbach, Sijen, Siu, Skalsky, Tam, Thibault, Vodovar, Watanabe, Waterhouse, Wu, Yan, Zeiner, Zeng   +55 more
core   +3 more sources

Viral-inducible Argonaute18 confers broad-spectrum virus resistance in rice by sequestering a host microRNA

eLife, 2015
Viral pathogens are a major threat to rice production worldwide. Although RNA interference (RNAi) is known to mediate antiviral immunity in plant and animal models, the mechanism of antiviral RNAi in rice and other economically important crops is poorly ...
Jianguo Wu, Zhirui Yang, Yu Wang, Lijia Zheng, Ruiqiang Ye, Yinghua Ji, Shanshan Zhao, Shaoyi Ji, Ruofei Liu, Le Xu, Hong Zheng, Yijun Zhou, Xin Zhang, Xiaofeng Cao, Lianhui Xie, Zujian Wu, Yijun Qi, Yi Li   +17 more
doaj   +1 more source

Chlorhexidine-filled porous ceramic coating fabricated by the aerosol deposition method for immediate and long-term enveloped virus inactivation

Journal of Asian Ceramic Societies, 2022
We developed an antiviral ceramic coating for immediate and long-term enveloped virus inactivation. The coating consisted of a porous ceramic coating fabricated by aerosol deposition and filled with chlorhexidine (CHX).
Taku Goto, Yoichi Yamada, Takeji Ueda, Sumiko Shiota, Mitsugu Sohma, Jun Akedo   +5 more
doaj   +1 more source

Synthesis of IFN-β by Virus-Infected Chicken Embryo Cells Demonstrated with Specific Antisera and a New Bioassay [PDF]

, 2004
Transcripts of interferon-α(IFN-α) and IFN-β genes are present in virus-infected chicken cells, but because of a lack of appropriate assays and reagents, it was unclear if biologically active IFN-β is secreted.
Harlin, Olof, Kaspers, Bernd, Ohnemus, Annette, Schwarz, Heike, Staeheli, Peter   +4 more
core   +1 more source

Antiviral Effects and Mechanisms of Active Ingredients in Tea

Molecules
Viruses play a significant role in human health, as they can cause a wide range of diseases, from mild illnesses to severe and life-threatening conditions.
Xinghai Zhang, Haonan Yu, Panjie Sun, Mengxin Huang, Bo Li   +4 more
doaj   +1 more source

Progress in Antiviral Fullerene Research

Nanomaterials, 2022
Unlike traditional small molecule drugs, fullerene is an all-carbon nanomolecule with a spherical cage structure. Fullerene exhibits high levels of antiviral activity, inhibiting virus replication in vitro and in vivo.
Piao-Yang Xu, Xiao-Qing Li, Wei-Guang Chen, Lin-Long Deng, Yuan-Zhi Tan, Qianyan Zhang, Su-Yuan Xie, Lan-Sun Zheng   +7 more
doaj   +1 more source

Antiviral RNA Interference against Orsay Virus Is neither Systemic nor Transgenerational in Caenorhabditis elegans. [PDF]

, 2015
UNLABELLED: Antiviral RNA-mediated silencing (RNA interference [RNAi]) acts as a powerful innate immunity defense in plants, invertebrates, and mammals. In Caenorhabditis elegans, RNAi is systemic; i.e., RNAi silencing signals can move between cells and ...
Ashe, Alyson, Le Pen, J?r?mie, Miska, Eric A., Sarkies, Peter, Tanguy, M?lanie   +4 more
core   +5 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source