Results 71 to 80 of about 355,010 (330)

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics

Advanced Healthcare Materials, EarlyView.
This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

In Vitro Evaluation of Cytotoxic and Anti-HCV-4 Properties of Sofosbuvir Encapsulated Chitosan Nanoparticles [PDF]

arXiv, 2020
Sofosbuvir is a potent HCV NS5B nucleotide polymerase inhibitor with broad genotypic coverage and low risk of developing drug resistance. While clinical studies have provided the effectiveness of sofosbuvir for treatment of patients with hepatitis C virus genotype 4 (HCV-4), however, many side-effects were reported.
arxiv  

Electrospinning and Nanofiber Technology: Fundamentals, Innovations, and Applications

Advanced Materials, EarlyView.
This review explores electrospinning fundamentals, methods for synthesizing polymer, metal oxide, carbon, and composite nanofibers, and advancements in fiber architectures like porous, core–shell, and aligned structures. It highlights applications in functional membranes, sensors, energy systems, and catalyst design while addressing future ...
Yujang Cho, Jong Won Beak, Mingyu Sagong, Seongcheol Ahn, Jong Seok Nam, Il‐Doo Kim   +5 more
wiley   +1 more source

BX795, a kinase inhibitor, inhibit duck plague virus infection via targeting US3 kinase

Poultry Science, 2023
: Duck plague virus (DPV) is a typical DNA virus of waterfowl, it causes huge economic losses to the duck industry due to the higher mortality and lower egg production.
Yanming Tian, Bin Tian, Mingshu Wang, Dongjie Cai, Anchun Cheng, Wei Zhang, Ying Wu, Qiao Yang, Xuming Ou, Di Sun, Shaqiu Zhang, Sai Mao, XinXin Zhao, Juan Huang, Qun Gao, Dekang Zhu, Renyong Jia, Shun Chen, Mafeng Liu   +18 more
doaj  

The Antiviral Activity of Trifluoromethylthiolane Derivatives

Chemistry Proceedings, 2022
The search for new antiviral agents is an important task today. The aim of this study was to elucidate the impact of trifluoromethylthiolane derivatives on herpetic and adenoviral infections.
Liubov Artiukh, Olga Povnitsa, Yuriy Shermolovich, Sergiy Siry, Svitlana Zahorodnia   +4 more
doaj   +1 more source

Docking study for Protein Nsp-12 of SARS-CoV with Betalains and Alfa-Bisabolol [PDF]

arXiv, 2020
The present Health Crisis tests the response of modern science and medicine to finding treatment for a new COVID-19 disease. The presentation on the world stage of antivirals such as remdesivir, obeys to the continuous investigation of biologically active molecules with multiple theoretical, computational and experimental tools.
arxiv  

Link between allosteric signal transduction and functional dynamics in a multi-subunit enzyme: S-adenosylhomocysteine hydrolase [PDF]

J. Am. Chem. Soc. (2011) vol. 133, 19807-19815, 2011
S-adenosylhomocysteine hydrolase (SAHH), a cellular enzyme that plays a key role in methylation reactions including those required for maturation of viral mRNA, is an important drug target in the discovery of antiviral agents. While targeting the active site is a straightforward strategy of enzyme inhibition, evidences of allosteric modulation of ...
arxiv   +1 more source

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

Advanced Materials Interfaces, EarlyView.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania, Manus J. P. Biggs, Katarzyna Krukiewicz   +2 more
wiley   +1 more source

In Vitro Activity of Ozone/Oxygen Gaseous Mixture against a Caprine Herpesvirus Type 1 Strain Isolated from a Goat with Vaginitis

Animals, 2023
Alphaherpesviruses cause genital lesions and reproductive failure in both humans and animals. Their control is mainly based on prevention using hygienic prophylactic measures due to the absence of vaccines and limitations of antiviral drug therapy. Ozone
Edoardo Lillo, Francesco Pellegrini, Annalisa Rizzo, Gianvito Lanave, Claudia Zizzadoro, Vincenzo Cicirelli, Cristiana Catella, Michele Losurdo, Vito Martella, Maria Tempesta, Michele Camero   +10 more
doaj   +1 more source

Antimalarial Artefenomel Inhibits Human SARS-CoV-2 Replication in Cells while Suppressing the Receptor ACE2 [PDF]

arXiv, 2020
The steep climbing of victims caused by the new coronavirus disease 2019 (COVID-19) throughout the planet is sparking an unprecedented effort to identify effective therapeutic regimens to tackle the pandemic. The SARS-CoV-2 virus is known to gain entry into various cell types through the binding of one of its surface proteins (spike) to the host ...
arxiv