Results 101 to 110 of about 3,598,763 (344)

Timing disparity of hepatocellular carcinoma (HCC) recurrence in a patient receiving interferon and subsequent direct antiviral agent (DAA) therapy for chronic hepatitis C [PDF]

, 2020
Christopher Cao, Dina Halegoua‐DeMarzio, Robert Coben, Mitchell Conn, Jorge Prieto, Howard Kroop, Anthony J. DiMarino, Hie‐Won Hann   +7 more
openalex   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Knowledge and Attitude Related to Hepatitis C among Medical Students in the Oral Direct Acting Antiviral Agents Era in Vietnam [PDF]

, 2022
Thi T. Hang Pham, Thị Thùy Linh Nguyễn, Samuel So, Van Thi Hai Hoang, Thi To Uyen Nguyen, Thanh Binh Ngo, Minh Phương Nguyễn, Quang Hung Thai, Ngoc Khoi Nguyen, Anh Le Ho Thi Quynh, Quang Phuc Tran, Trung Son, Mehlika Toy, Phạm Minh Khuê   +13 more
openalex   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

The pan-variant potential of light: 425 nm light inactivates SARS-CoV-2 variants of concern and non-cytotoxic doses reduce viral titers in human airway epithelial cells

mSphere
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) prolonged the coronavirus disease 2019 (COVID-19) pandemic. The continued development of novel pan-variant therapeutics to treat currently circulating and future VOCs
Nathan Stasko, Leslee Arwood, Nicole Jandick, Derry Spragion, Rachel C. Roberts, Mónica Setién, Ibrahim Henson, Abigail Annas, M. Leslie Fulcher, Marisa Brotton, Larry Kummer, Frank Szaba, Matt Reagan, Kathleen Lanzer, Tres Cookenham, Sean Casey, Nagarama Kothapalli, Tricia Hart, Shelton S. Bradrick, David Emerson, Adam S. Cockrell, Scott H. Randell, Jacob F. Kocher   +22 more
doaj   +1 more source

Cobalt Complexes as Antiviral and Antibacterial Agents

Pharmaceuticals, 2010
Metal ion complexes are playing an increasing role in the development of antimicrobials. We review here the antimicrobial properties of cobalt coordination complexes in oxidation state 3+.
Eddie L. Chang, Christa Simmers, D. Andrew Knight   +2 more
doaj   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

Hepatitis C in healthcare personnel: follow-up analysis of treatments with direct-acting antiviral agents [PDF]

, 2021
Claudia Westermann, Dana Wendeler, Albert Nienhaus   +2 more
openalex   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Risk of Hepatocellular Cancer in HCV Patients Treated With Direct-Acting Antiviral Agents.

Gastroenterology, 2017
BACKGROUND AND AIMS The risk of hepatocellular cancer (HCC) after sustained virological response (SVR) with direct-acting antivirals (DAA) is unclear. Our aim was to examine the risk and determinants of HCC in patients cured with DAA.
F. Kanwal, J. Kramer, S. Asch, M. Chayanupatkul, Yumei Cao, H. El‐Serag   +5 more
semanticscholar   +1 more source