Results 31 to 40 of about 4,080,754 (294)
Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral Drugs
Emerging Infectious Diseases, 2004 Severe acute respiratory syndrome (SARS) is an infectious disease caused by a newly identified human coronavirus (SARS-CoV). Currently, no effective drug exists to treat SARS-CoV infection.
Emily L.C. Tan +6 more
doaj +1 more source
Ribonucleases as antiviral agents [PDF]
Molecular Biology, 2014 Many ribonucleases (RNases) are able to inhibit the reproduction of viruses in infected cell cultures and laboratory animals, but the molecular mechanisms of their antiviral activity remain unclear. The review discusses the well-known RNases that possess established antiviral effects, including both intracellular RNases (RNase L, MCPIP1 protein, and ...
Ilinskaya O., Mahmud R.
openaire +4 more sources
Metal Complexes as Antiviral Agents for SARS‐CoV‐2
ChemBioChem, 2021 The severe acute respiratory syndrome – coronavirus 2 (SARS‐CoV‐2), the infectious agent responsible for COVID‐19 – has caused more than 2.5 million deaths worldwide and triggered a global pandemic. Even with successful vaccines being delivered, there is
J. Karges, Seth M. Cohen
semanticscholar +1 more source
Engineering recombinantly expressed lectin-based antiviral agents
Frontiers in Cellular and Infection Microbiology, 2022 Cyanovirin-N (CV-N), a lectin from Nostoc ellipsosporum was found an infusion inhibitory protein for human immunodeficiency virus (HIV)-1. A tandem-repeat of the engineered domain-swapped dimer bound specific sites at hemagglutinin (HA), Ebola and HIV ...
Irene Maier
doaj +1 more source
Seven classes of antiviral agents
Cellular and Molecular Life Sciences, 2022 The viral epidemics and pandemics have stimulated the development of known and the discovery of novel antiviral agents. About a hundred mono- and combination antiviral drugs have been already approved, whereas thousands are in development.
A. Ianevski +7 more
semanticscholar +1 more source
Lycorine Derivative LY-55 Inhibits EV71 and CVA16 Replication Through Downregulating Autophagy
Frontiers in Cellular and Infection Microbiology, 2019 Hand, foot, and mouth disease (HFMD) is a global health concern, especially in the Asia-Pacific region. HFMD caused by Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) infection is usually self-limited but occasionally leads to severe pulmonary edema,
Huiqiang Wang +7 more
doaj +1 more source
Comparison of Antiviral Agents for Seasonal Influenza Outcomes in Healthy Adults and Children
JAMA Network Open, 2021 Key Points Question What antiviral agents for treating seasonal influenza are associated with the most safety and best outcomes among healthy adults and children?
Jen-Wei Liu +4 more
semanticscholar +1 more source
Kinase Inhibitors as Underexplored Antiviral Agents
Journal of Medicinal Chemistry, 2021 Viral infections are a major health problem; therefore, there is an urgent need for novel therapeutic strategies. Antivirals used to target proteins encoded by the viral genome usually enhance drug resistance generated by the virus.
Javier García-Cárceles +3 more
semanticscholar +1 more source
mSphere, 2016 Antimicrobial-resistant infections are an urgent public health threat, and development of novel antimicrobial therapies has been painstakingly slow. Polymicrobial infections are increasingly recognized as a significant source of severe disease and also ...
Jeffrey A. Melvin +6 more
doaj +1 more source
mBio, 2022 Amino acid substitutions I38T and E23K in the influenza polymerase acidic (PA) protein lead to reduced susceptibility to the influenza antiviral drug baloxavir.
Paulina Koszalka +4 more
doaj +1 more source